The role of pH sensitive G protein OGR1 in association between lung and kidney

Research Project

Project/Area Number	18K08909
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 55060:Emergency medicine-related
Research Institution	Gunma University
Principal Investigator	Ikeuchi Hidekazu 群馬大学, 医学部附属病院, 助教 (60420113)
Project Period (FY)	2018-04-01 – 2021-03-31
Project Status	Completed (Fiscal Year 2020)
Budget Amount *help	¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000) Fiscal Year 2020: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000) Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000) Fiscal Year 2018: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords	pH調節 / 肺腎関連 / 腸内細菌 / 急性腎障害 / 敗血症 / OGR1 / GPR68 / 肺障害 / 腎障害 / 急性呼吸不全 / GPCR
Outline of Final Research Achievements	We used various models of pulmonary and renal injury to elucidate the role of OGR1, a representative pH-regulating GPCR, in pulmonary and renal-related diseases and its prognostic mechanism. We compared the histological analysis, blood gas analysis, and cytokine levels in blood and alveolar fluid. In conclusion, we found no difference between the two groups under the established conditions, and no positive difference in lung-renal association.
Academic Significance and Societal Importance of the Research Achievements	pH調節性GPCRであるOGR1に関しては、肺腎関連に与える影響はないことが判明した。