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A study of pathological subtypes and glucose metabolism in craniopharyngioma

Research Project

Project/Area Number 18K08937
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 56010:Neurosurgery-related
Research InstitutionGunma University

Principal Investigator

Tosaka Masahiko  群馬大学, 大学院医学系研究科, 准教授 (40323357)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords頭蓋咽頭腫 / エナメル上皮腫型 / 乳頭型 / 糖代謝 / GLUT-1 / Hexokinase-2 / FDG-PET / トルコ鞍部腫瘍 / トルコ鞍上部腫瘍 / BRAF変異 / 扁平上皮乳頭型 / 下垂体腺腫
Outline of Final Research Achievements

Craniopharyngioma, a type of brain tumor, is classified into two subtypes, the adamantinomatous type and the papillary type. Of these, it has recently been reported that the papillary type is caused by mutations in the BRAF gene. In a previous study, we suspected that only the papillary type had increased metabolism of glucose in the tumor. We used tissue specimens of craniopharyngioma to investigate whether upregulation of glucose metabolism-related proteins was observed. We then investigated whether it was consistent with BRAF mutations and increased glucose metabolism in FDG-PET (a test that images glucose metabolism). As a result, it was proved for the first time that BRAF mutation, increased expression of glucose metabolism-related protein, and increased glucose metabolism in FDG-PET were observed only in the papillary type of craniopharyngioma.

Academic Significance and Societal Importance of the Research Achievements

頭蓋咽頭腫は稀ながら頭蓋底部に存在し再発を繰り返す治療困難な脳腫瘍の一種です。この腫瘍の二つのサブタイプ(エナメル上皮腫型と乳頭型)の内、乳頭型だけはBRAF遺伝子の変異が原因であることが報告され、BRAF阻害剤という化学療法薬が、腫瘍を縮小させるとの報告がなされました。私たちの研究により、開頭手術を行うことなしにこの二つのサブタイプについて正確に診断することができれば、化学療法薬の治療効果を事前に予想することが可能となり、将来、適切な化学療法を行うことが可能になります。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (11 results)

All 2021 2020 2019

All Journal Article (5 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 5 results,  Open Access: 2 results) Presentation (4 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results) Book (2 results)

  • [Journal Article] Subtype-dependent difference of glucose transporter 1 and hexokinase II expression in craniopharyngioma: an immunohistochemical study2021

    • Author(s)
      Mukada Naoto、Tosaka Masahiko、Matsumura Nozomi、Yamaguchi Rei、Aihara Masanori、Isoda Koji、Higuchi Tetsuya、Tsushima Yoshito、Yokoo Hideaki、Yoshimoto Yuhei
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 126-126

    • DOI

      10.1038/s41598-020-80259-4

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sagittal bending of the optic nerve at the entrance from the intracranial to the optic canal and ipsilateral visual acuity in patients with sellar and suprasellar lesions2021

    • Author(s)
      Yamaguchi Rei、Tosaka Masahiko、Miyagishima Takaaki、Osawa Tadashi、Horiguchi Keishi、Honda Fumiaki、Yoshimoto Yuhei
    • Journal Title

      Journal of Neurosurgery

      Volume: 134 Issue: 1 Pages: 180-188

    • DOI

      10.3171/2019.9.jns191365

    • Related Report
      2020 Annual Research Report 2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] The protective role of proton-sensing TDAG8 in the brain injury in a mouse ischemia reperfusion model.2020

    • Author(s)
      Sato K, Tobo A, Mogi C, Tobo M, Yamane N, Tosaka M, Tomura H, Im DS, Okajima F.
    • Journal Title

      Sci Rep.

      Volume: 10 Issue: 1 Pages: 17193-17193

    • DOI

      10.1038/s41598-020-74372-7

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Extended endoscopic endonasal resection of craniopharyngioma using intraoperative visual evoked potential monitoring: technical note.2019

    • Author(s)
      Miyagishima T, Tosaka M, Yamaguchi R, Nagaki T, Ishii N, Kojima T, and Yoshimoto Y.
    • Journal Title

      Acta Neurochir (Wien)

      Volume: 161 Issue: 11 Pages: 2277-2284

    • DOI

      10.1007/s00701-019-04028-7

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Combined supra-infrasellar approach to pituitary macroadenoma with oculomotor cistern extension: surgical strategy and experience2019

    • Author(s)
      Tosaka M, Shimizu T, Miyagishima T, Tanaka Y, Osawa T, Aihara M, Yamaguchi R, Yoshimoto Y.
    • Journal Title

      Acta Neurochir (Wien)

      Volume: 161 Issue: 5 Pages: 1025-1031

    • DOI

      10.1007/s00701-019-03869-6

    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed
  • [Presentation] 成長ホルモン産生下垂体腺腫の外科治療2021

    • Author(s)
      登坂 雅彦
    • Organizer
      第94回日本内分泌学会学術総会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Surgical strategy using extended endoscopic transsphenoidal approach for craniopharyngioma: single center experience2020

    • Author(s)
      Tosaka M, Yamaguchi R, Aihara M, Miyagishima T, Yoshimoto Y.
    • Organizer
      NASBS Annual meeting
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Surgical strategy using extended endoscopic transsphenoidal approach for craniopharyngioma: single center experience2020

    • Author(s)
      Tosaka M, Yamaguchi R, Aihara M, Miyagishima T, Yoshimoto Y.
    • Organizer
      15th Asian-Oseanian International Congress on Skull Base Surgery
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 内視鏡下拡大蝶形骨洞腫瘍摘出術における大腿筋膜によるパッチワー ク縫合を用いた頭蓋底再建2020

    • Author(s)
      登坂 雅彦, 山口 玲, 藍原 正憲, 宮城島 孝昭, 向田 直人, 好本 裕平
    • Organizer
      第79回日本脳神経外科学会総会
    • Related Report
      2020 Annual Research Report
  • [Book] 内分泌画像検査マニュアル第2版2021

    • Author(s)
      登坂雅彦 (分担執筆)
    • Total Pages
      2
    • Publisher
      診断と治療社
    • Related Report
      2020 Annual Research Report
  • [Book] 下垂体疾患診療マニュアル第3版2021

    • Author(s)
      登坂雅彦 (分担執筆)
    • Total Pages
      2
    • Publisher
      診断と治療社
    • Related Report
      2020 Annual Research Report

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Published: 2018-04-23   Modified: 2022-01-27  

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