| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
In this study, we investigated treatments targeting Guanosine triphosphate (GTP) metabolism in malignant gliomas. Mycophenolic acid (MPA) is a drug that has been shown to reduce GTP relative to cell lines. This MPA significantly reduces the intracellular GTP level by suppressing the production of Inosine-5'-monophosphate dehydrogenase (IMPDH). The effect of MPA was examined on tumor stem cells prepared from brain tumor cell lines and surgically removed samples, and the tumor cell proliferation inhibitory effect of MPA was obtained. The tumor was divided and collected by surgery with reference to imaging findings such as MRI and PET. Tumors in this methionine accumulated area were shown to have increased IMPDH2 in the mRNA microarray. In malignant glioma, high expression of IMPDH2 increased the ability to synthesize rRNA and tRNA. It was found that suppression of IMPDH2 has an effect of suppressing cell proliferation.
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