Growth suppression of pituitary adenoma through regulation of vasogenesis

• Project/Area Number: 18K08952
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56010:Neurosurgery-related
• Research Institution: Teikyo University
• Principal Investigator: MATSUNO AKIRA 帝京大学, 医学部, 教授 (00242058)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 下垂体腺腫 / 血管新生 / Cathepsin D / FGF2 / 血管構築 / Vasoinhibin / Cathepsin D / 増殖抑制

Outline of Final Research Achievements

Prolactin and growth hormone promote angiogenesis through direct and indirect action on vascular endothelial cells, whereas they have reverse effect in various pathophysiological conditions via proteolytic cleavage by Cathepsin D and bone morphogenetic protein 1 (BMP-1). In this research, angiogenesis in pituitary adenoma is analyzed with special focus on these molecules.

Academic Significance and Societal Importance of the Research Achievements

機能性下垂体腺腫、特に成長ホルモン(GH)や副腎皮質刺激ホルモン(ACTH)産生下垂体腺腫、さらには悪性度が極めて高く生命予後が不良である下垂体癌に対する薬物治療はいまだ困難である。下垂体腺腫においても腺腫への血流は重要であり、血管形成の機序の解明が病態を明らかにしその治療につながると考えられる。この観点より、本研究では、下垂体腺腫における血管構築に焦点をあて、血管構築に関する新規の分子の役割と発現を検討し、血管構築に関する新規の分子の制御を通じた、新規治療法の確立を探求した。

Research Products

• [Journal Article] Fabrication and evaluation of a xenogeneic decellularized nerve-derived material: preclinical studies of a new strategy for nerve repair (2020)
  • Author(s): Li T, Sui Z, Matsuno A, Ten H, Oyama K, Ito A, Jiang H, Ren X, Javed R, Zhang L, Ao Q
  • Journal Title: Neurotherapeutics Volume: 17 Issue: 1 Pages: 356-370
  • DOI: 10.1007/s13311-019-00794-5
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] A case of nervus intermedius neuralgia (2020)
  • Author(s): Onoda K, Kawaguchi A, Takaya Y, Saito Y, Ishikawa H, Uno T, Miyamoto M, Oyama K, Matsuno A
  • Journal Title: World Neurosurg Volume: 137 Pages: 89-92
  • DOI: 10.1016/j.wneu.2020.01.034
  • Peer Reviewed
• [Journal Article] Fibrin glue/fibronectin/heparin-based delivery system of BMP2 induces osteogenesis in MC3T3-E1 cells and bone formation in rat calvarial critical-sized defects (2020)
  • Author(s): Ao Q, Wang S, He Q, Ten H, Oyama K, Ito A, He J, Javed R, Wang A, Matsuno A
  • Journal Title: ACS Applied Materials & Interfaces Volume: 12 Issue: 11 Pages: 13400-13410
  • DOI: 10.1021/acsami.0c01371
  • Peer Reviewed
• [Journal Article] Significant benefits of AIP testing and clinical screening in familial isolated and young-onset pituitary tumors (2020)
  • Author(s): Marques P, Caimari F, Hernandez-Ramirez LC, Collier D, Iacovazzo D, Ronaldson A, Magid K, Lim CT, Stals K, Ellard S, Grossman AB , Korbonits M (on behalf of the FIPA Consortium)
  • Journal Title: J Clin Endocrinol Metab Volume: 105 Issue: 6 Pages: e2247-e2260
  • DOI: 10.1210/clinem/dgaa040
  • Peer Reviewed
• [Journal Article] A Case of Intravascular Treatment for Acute Ischemic Stroke with Internal Carotid Artery Stenosis That Developed While Driving (2020)
  • Author(s): Oyama Y, Miyamoto M, Onuki T, Uno T, Ito A, Yamane F, Sakamoto T, Matsuno A
  • Journal Title: Journal of Neuroendovascular Therapy Volume: 14 Issue: 8 Pages: 313-318
  • DOI: 10.5797/jnet.cr.2019-0090
  • NAID: 130007889247
  • ISSN: 1882-4072, 2186-2494
  • Peer Reviewed
• [Journal Article] Occipital lobe epilepsy was presented in a patient with intracerebral schwannoma: a case report and literature review (2019)
  • Author(s): Ten H, Adachi K, Yamaguchi F, Matsuno A, Teramoto A, Morita A
  • Journal Title: Int J Neurosci Volume: 129 Issue: 3 Pages: 308-312
  • DOI: 10.1080/00207454.2018.1526797
  • Peer Reviewed
• [Journal Article] 嚢胞性下垂体偶発腫の治療指針 (2019)
  • Author(s): 大山健一、廣畑倫生、江戸直樹、盛田幸司、石川敏夫、寺本明、松野彰
  • Journal Title: ACTH RELATED PEPTIDES Volume: 30 Pages: 31-31
  • Peer Reviewed
• [Journal Article] 高流量バイパス術におけるバリエーション-より安全・確実・シンプルな方法を目指して- (2019)
  • Author(s): 大井川秀聡、宇野健志、栗田浩樹、松野彰
  • Journal Title: 脳卒中の外科 Volume: 47 Pages: 103-108
  • NAID: 130007661017
  • Peer Reviewed
• [Journal Article] 多発外傷における損傷部位と線溶亢進の関係：頭部外傷データバンク [プロジェクト 2015] より (2019)
  • Author(s): 大貫隆広、中原慎二、坂本哲也、大山裕太、朝見正宏、安心院康彦、三宅康史、松野彰
  • Journal Title: 神経外傷 Volume: 42 Pages: 119-126
  • NAID: 130007828334
  • Peer Reviewed
• [Journal Article] Headache in patients with chronic subdural hematoma: analysis in 1080 patients (2018)
  • Author(s): Yamada Shoko M.、Tomita Yusuke、Murakami Hideki、Nakane Makoto、Yamada So、Murakami Mineko、Hoya Katsumi、Nakagomi Tadayoshi、Tamura Akira、Matsuno Akira
  • Journal Title: Neurosurgical Review Volume: 41 Issue: 2 Pages: 549-556
  • DOI: 10.1007/s10143-017-0889-x
  • Peer Reviewed
• [Journal Article] Isolated Shoulder Palsy due to Intracerebral Hemorrhage (2018)
  • Author(s): Takamichi Kanbayashi, Takehiro Watanabe, Yuta Oyama, Akira Matsuno, Masahiro Sonoo
  • Journal Title: Internal Medicine Volume: 57 Issue: 8 Pages: 1159-1161
  • DOI: 10.2169/internalmedicine.9356-17
  • NAID: 130006707790
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed
• [Journal Article] Aneurysm trapping by both direct and endovascular surgery for vertebral artery dissection: A case report (2018)
  • Author(s): Katsuno Makoto、Matsuno Akira
  • Journal Title: Surgical Neurology International Volume: 9 Issue: 1 Pages: 10-10
  • DOI: 10.4103/sni.sni_382_17
  • Peer Reviewed
• [Journal Article] Safety and convenience of once-weekly somapacitan in adult GH deficiency: a 26-week randomized, controlled trial (2018)
  • Author(s): Johannsson Gudmundur,et al. REAL 2 study Group
  • Journal Title: European Journal of Endocrinology Volume: 178 Issue: 5 Pages: 491-499
  • DOI: 10.1530/eje-17-1073
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Subdural Tension on the Brain in Patients with Chronic Subdural Hematoma Is Related to Hemiparesis but Not to Headache or Recurrence (2018)
  • Author(s): Tomita Yusuke、Yamada Shoko Merrit、Yamada Shokei、Matsuno Akira
  • Journal Title: World Neurosurgery Volume: 119 Pages: e518-e526
  • DOI: 10.1016/j.wneu.2018.07.192
  • Peer Reviewed
• [Journal Article] 傍前床突起部内頚動脈瘤に対する直達術手術手技と治療成績 (2018)
  • Author(s): 大井川秀聡、竹田理々子、小倉丈司、栗田浩樹、松野彰
  • Journal Title: 脳卒中の外科 Volume: 46 Pages: 104-110
  • NAID: 130006712151
  • Peer Reviewed
• [Journal Article] 嚢胞性下垂体偶発腫の治療方針 (2018)
  • Author(s): 大山健一、廣畑倫生、石井雄道、田原重志、山王なほ子、寺本明、森田明夫、松野彰
  • Journal Title: 日本内分泌学会雑誌 Volume: 94[Suppl, HPT, Oct] Pages: 45-47
  • Peer Reviewed
• [Presentation] Neuroendoscopic surgery and open surgery for pituitary and parasellar lesions with consideration for difficult cases (2018)
  • Author(s): Matsuno A
  • Organizer: WFNS Foundation Acns Live Seminar Uzbekistan
• [Presentation] Current treatment strategy for functioning pituitary adenomas (2018)
  • Author(s): Matsuno A
  • Organizer: WFNS Foundation Acns Live Seminar Uzbekistan