Growth suppression of pituitary adenoma through regulation of vasogenesis
Project/Area Number |
18K08952
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 56010:Neurosurgery-related
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Research Institution | Teikyo University |
Principal Investigator |
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Project Period (FY) |
2018-04-01 – 2021-03-31
|
Project Status |
Completed (Fiscal Year 2020)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 下垂体腺腫 / 血管新生 / Cathepsin D / FGF2 / 血管構築 / Vasoinhibin / Cathepsin D / 増殖抑制 |
Outline of Final Research Achievements |
Prolactin and growth hormone promote angiogenesis through direct and indirect action on vascular endothelial cells, whereas they have reverse effect in various pathophysiological conditions via proteolytic cleavage by Cathepsin D and bone morphogenetic protein 1 (BMP-1). In this research, angiogenesis in pituitary adenoma is analyzed with special focus on these molecules.
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Academic Significance and Societal Importance of the Research Achievements |
機能性下垂体腺腫、特に成長ホルモン(GH)や副腎皮質刺激ホルモン(ACTH)産生下垂体腺腫、さらには悪性度が極めて高く生命予後が不良である下垂体癌に対する薬物治療はいまだ困難である。下垂体腺腫においても腺腫への血流は重要であり、血管形成の機序の解明が病態を明らかにしその治療につながると考えられる。この観点より、本研究では、下垂体腺腫における血管構築に焦点をあて、血管構築に関する新規の分子の役割と発現を検討し、血管構築に関する新規の分子の制御を通じた、新規治療法の確立を探求した。
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] Fabrication and evaluation of a xenogeneic decellularized nerve-derived material: preclinical studies of a new strategy for nerve repair2020
Author(s)
Li T, Sui Z, Matsuno A, Ten H, Oyama K, Ito A, Jiang H, Ren X, Javed R, Zhang L, Ao Q
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Journal Title
Neurotherapeutics
Volume: 17
Issue: 1
Pages: 356-370
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Significant benefits of AIP testing and clinical screening in familial isolated and young-onset pituitary tumors2020
Author(s)
Marques P, Caimari F, Hernandez-Ramirez LC, Collier D, Iacovazzo D, Ronaldson A, Magid K, Lim CT, Stals K, Ellard S, Grossman AB , Korbonits M (on behalf of the FIPA Consortium)
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Journal Title
J Clin Endocrinol Metab
Volume: 105
Issue: 6
Pages: e2247-e2260
DOI
Related Report
Peer Reviewed
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