Development of methods for optimization of deep brain stimulation parameters by establishing the biomarders indicating severity in Parkinson's disease

• Project/Area Number: 18K08956
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56010:Neurosurgery-related
• Research Institution: Fukuoka University
• Principal Investigator: Morishita Takashi 福岡大学, 医学部, 講師 (20750756)
• Project Period (FY): 2018-04-01 – 2024-03-31
• Project Status: Completed (Fiscal Year 2023)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2021: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: パーキンソン病 / 生体指標 / 近赤外光 / 脳深部刺激療法 / 脳活動 / バイオマーカー / 脳神経ネットワーク / 脳可塑性 / 光イメージング / 機能的神経外科

Outline of Final Research Achievements

This study aims to optimize deep brain stimulation (DBS) therapy for patients with Parkinson's disease. Primarily, it involves using a device based on near-infrared spectroscopy (NIRS) to measure brain activity, with the goal of establishing effective biomarkers and exploring stimulation conditions based on these markers. Additionally, through a multi-center collaborative study, the research identifies the optimal electrode placement sites and neural fiber tracts using new brain stimulation devices to enhance the effectiveness of DBS. This approach aims to set treatment conditions tailored to each patient, thereby improving therapeutic outcomes and the quality of life for patients.

Academic Significance and Societal Importance of the Research Achievements

学術的には、脳深部刺激療法の刺激条件最適化に寄与する新しい知見を提供し、パーキンソン病の重症度評価における生体指標の確立を進めることができた。社会的には、パーキンソン病患者の治療効果を向上させ、生活の質を改善することが期待される。これにより、　脳深部刺激療法の臨床応用がさらに進展し、より多くの患者に恩恵がもたらされる可能性がある。また、治療の個別化が進み、医療費の削減や患者の負担軽減にもつながると考えられる。

Research Products

• [Journal Article] Asymptomatic cable twisting in a patient with impending Twiddler syndrome detected during deep brain stimulation surgery for Parkinson’s disease: A case report (2024)
  • Author(s): Permana Galih Indra、Morishita Takashi、Tanaka Hideaki、Matsushita Ryuji、Kobayashi Hiromasa、Abe Hiroshi
  • Journal Title: Surgical Neurology International Volume: 15 Pages: 86-86
  • DOI: 10.25259/sni_844_2023
  • Peer Reviewed
• [Journal Article] Proceedings of the 11th Annual Deep Brain Stimulation Think Tank: pushing the forefront of neuromodulation with functional network mapping, biomarkers for adaptive DBS, bioethical dilemmas, AI-guided neuromodulation, and translational advancements (2024)
  • Author(s): Johnson Kara A.、Dosenbach Nico U. F.、Gordon Evan M.、Welle Cristin G.、Wilkins Kevin B.、Bronte-Stewart Helen M.、Voon Valerie、Morishita Takashi、Sakai Yuki et al.
  • Journal Title: Frontiers in Human Neuroscience Volume: 18 Pages: 1-23
  • DOI: 10.3389/fnhum.2024.1320806
  • Peer Reviewed
• [Journal Article] Tremor Rebound Due to a Deep Brain Stimulation Electrode Fracture with Normal Impedance Treated by Rescue Thalamotomy in a Patient with Essential Tremor: A Case Report (2024)
  • Author(s): Hashikawa Takeshi、Indra Permana Galih、Morishita Takashi、Koga Takayuki、Tanaka Hideaki、Kobayashi Hiromasa、Abe Hiroshi
  • Journal Title: Interdisciplinary Neurosurgery Volume: 36 Pages: 101975-101975
  • DOI: 10.1016/j.inat.2024.101975
  • Peer Reviewed
• [Journal Article] Microlesion Effect Induced by Electrode Implantation in the Posteroventral Globus Pallidus Interna for Severe Dystonic Tics (2024)
  • Author(s): Permana Galih Indra、Morishita Takashi、Tanaka Hideaki、Iida Hitoshi、Fujioka Shinsuke、Abe Hiroshi
  • Journal Title: Tremor and Other Hyperkinetic Movements Volume: 14 Issue: 1 Pages: 1-5
  • DOI: 10.5334/tohm.837
  • Peer Reviewed
• [Journal Article] Precision Mapping of Thalamic Deep Brain Stimulation Lead Positions Associated With the Microlesion Effect in Tourette Syndrome (2023)
  • Author(s): Morishita Takashi、Sakai Yuki、Iida Hitoshi、Yoshimura Saki、Fujioka Shinsuke、Oda Kazunori、Tanaka Saori C.、Abe Hiroshi
  • Journal Title: Neurosurgery Volume: 93 Issue: 4 Pages: 875-883
  • DOI: 10.1227/neu.0000000000002484
• [Journal Article] Precision Mapping of Thalamic Deep Brain Stimulation Lead Positions Associated with the Microlesion Effect in Tourette Syndrome (2023)
  • Author(s): Takashi Morishita , Yuki Sakai , Hitoshi Iida , Saki Yoshimura , Shinsuke Fujioka , Kazunori Oda , Saori Tanaka , Hiroshi Abe
  • Journal Title: Neurosurgery Volume: - Pages: 1-9
  • DOI: 10.1101/2022.09.07.22279661
  • Peer Reviewed / Open Access
• [Journal Article] Unilateral GPi-DBS Improves Ipsilateral and Axial Motor Symptoms in Parkinson's Disease as Evidenced by a Brain Perfusion Single Photon Emission Computed Tomography Study. (2022)
  • Author(s): Yuka Hayashi, Takayasu Mishima, Shinsuke Fujioka, Takashi Morishita, Tooru Inoue, Shigeki Nagamachi, Yoshio Tsuboi
  • Journal Title: Frontiers in human neuroscience Volume: 16 Pages: 888701-888701
  • DOI: 10.3389/fnhum.2022.888701
  • Peer Reviewed / Open Access
• [Journal Article] Pain Relief Following Selective Tibial Neurotomy for Spastic Equinus Foot Secondary to Stroke and Traumatic Brain Injury (2022)
  • Author(s): Kazunori Oda , Takashi Morishita , Aya Yatsugi , Koichi Miki , Takuya Uchiyama , Hideaki Tanaka , Hiroshi Abe , Tooru Inoue
  • Journal Title: World neurosurgery Volume: 166 Pages: e583-e589
  • DOI: 10.1016/j.wneu.2022.07.053
  • Peer Reviewed
• [Journal Article] Case report: Radiofrequency thalamotomy as palliative care for Holmes tremor in a patient with terminal cancer and cardiac pacemaker (2022)
  • Author(s): Kazunori Oda , Takashi Morishita , Hideaki Tanaka , Hiromasa Kobayashi , Hiroshi Abe
  • Journal Title: Surgical neurology international Volume: 13 Pages: 484-484
  • DOI: 10.25259/sni_618_2022
  • Peer Reviewed / Open Access
• [Journal Article] Effect of Robot-assisted Rehabilitation to Botulinum Toxin A Injection for Upper Limb Disability in Patients with Chronic Stroke: A Case Series and Systematic Review (2022)
  • Author(s): HYAKUTAKE Koichi、MORISHITA Takashi、SAITA Kazuya、FUKUDA Hiroyuki、ABE Hiroshi、OGATA Toshiyasu、KAMADA Satoshi、INOUE Tooru
  • Journal Title: Neurologia medico-chirurgica Volume: 62 Issue: 1 Pages: 35-44
  • DOI: 10.2176/nmc.oa.2020-0408
  • NAID: 130008141856
  • ISSN: 0470-8105, 1349-8029
  • Peer Reviewed
• [Journal Article] Vagus nerve stimulation for bilateral temporal lobe epilepsy caused by fractionated radiation therapy: A case report (2022)
  • Author(s): Matsuo Yoko、Tanaka Hideaki、Morishita Takashi、Enatsu Rei、Inoue Tooru
  • Journal Title: Interdisciplinary Neurosurgery Volume: 27 Pages: 101429-101429
  • DOI: 10.1016/j.inat.2021.101429
• [Journal Article] Case report: Favorable outcomes of spinal cord stimulation in complex regional pain syndrome Type II consistent with thermography findings (2021)
  • Author(s): Oda Kazunori、Morishita Takashi、Shibata Shiho、Tanaka Hideaki、Hirai Norimasa、Inoue Tooru
  • Journal Title: Surgical Neurology International Volume: 12 Pages: 598-598
  • DOI: 10.25259/sni_959_2021
  • Peer Reviewed
• [Journal Article] Case Report: GPi DBS for Non-parkinsonian Midline Tremor: A Normative Connectomic Comparison to a Failed Thalamic DBS (2021)
  • Author(s): Morishita Takashi、Sakai Yuki、Mishima Takayasu、Umemoto George、Okun Michael S.、Tanaka Saori C.、Tsuboi Yoshio、Inoue Tooru
  • Journal Title: Frontiers in Human Neuroscience Volume: 15 Pages: 709552-709552
  • DOI: 10.3389/fnhum.2021.709552
  • Peer Reviewed / Open Access
• [Journal Article] Neuroanatomical Considerations for Optimizing Thalamic Deep Brain Stimulation in Tourette Syndrome (2021)
  • Author(s): Morishita T, Sakai Y, Iida H, Yoshimura S, Ishii A, Fujioka S, Tanaka S, Inoue T
  • Journal Title: Journal of Neurosurgery Volume: -
  • DOI: 10.1101/2020.09.29.20200501
  • Peer Reviewed / Open Access
• [Journal Article] Radiofrequency Ventro-Oral Thalamotomy for Post-Stroke Focal Dystonia in a Pediatric Patient (2021)
  • Author(s): Hirao N, Morishita T, Saita K, Takagi T, Fujioka S, Inoue T
  • Journal Title: NMC Case Report Journal Volume: -
  • NAID: 130008072220
  • Peer Reviewed / Open Access
• [Journal Article] Surgical Management of Adverse Events Associated with Deep Brain Stimulation: A Single-Center Experience (2020)
  • Author(s): Nonaka M, Morishita T, Yamada K, Fujioka S, Higuchi M, Tsuboi Y, Abe H, Inoue T
  • Journal Title: SAGE Open Medicine Volume: 8 Pages: 1-8
  • DOI: 10.1177/2050312120913458
  • Peer Reviewed / Open Access
• [Journal Article] Choreo-ballistic Movement after Thalamotomy in a Patient with Lewy Body Dementia (2019)
  • Author(s): Saitoh T, Enatsu R, Kitagawa M, Morishita T, Suzuki Y, Mikami T, Mikuni N
  • Journal Title: Journal of Clinical Neuroscience Volume: 66 Pages: 264-266
  • DOI: 10.1016/j.jocn.2019.05.048
  • Peer Reviewed
• [Journal Article] A retrospective evaluation of thalamic targeting for tremor deep brain stimulation using high-resolution anatomical imaging with supplementary fiber tractography (2019)
  • Author(s): Takashi Morishita, Masa-aki Higuchi, Hiromasa Kobayashi, Hiroshi Abe, Toshio Higashi, Tooru Inoue
  • Journal Title: Journal of the Neurological Sciences Volume: 15 Pages: 148-156
  • DOI: 10.1016/j.jns.2019.01.025
  • Peer Reviewed
• [Presentation] Normative connectomic approaches in deep brain stimulation (2023)
  • Author(s): Takashi Morishita, Hiroshi Abe
  • Organizer: AASSFN 2023
  • Invited
• [Presentation] A variety of clinical responses to thalamic DBS in the individual Tourette syndrome patients (2023)
  • Author(s): Takashi Morishita, Hiroshi Abe
  • Organizer: Deep Brain Stimulation Think Tank XI
  • Invited
• [Presentation] Connectomic analysis of deep brain stimulation effects (2023)
  • Author(s): Takashi Morishita, Hiroshi Abe
  • Organizer: AANS 2023 Los Angeles
  • Invited
• [Presentation] パーキンソン病に対する adaptive DBS の現状:利点と問題点 (2022)
  • Author(s): 森下登史, 安部洋
  • Organizer: 日本脳神経外科学会第81回学術総会
• [Presentation] パーキンソン病に対する脳深部刺激療法 up to date (2020)
  • Author(s): 森下登史, 井上亨
  • Organizer: 第40回脳神経外科コングレス総会
  • Invited
• [Presentation] パーキンソン病における薬物療法と脳深部刺激療法の基底核-皮質ネットワークへの作用機序の相違 (2019)
  • Author(s): 森下登史
  • Organizer: 日本脳神経外科学会 第79回学術総会
• [Presentation] Stereotactic Neurosurgery Practice in Japan/Asia (2019)
  • Author(s): Takashi Morishita
  • Organizer: 18th Meeting of The World Society for Stereotactic and Functional Neurosurgery
  • Int'l Joint Research / Invited
• [Presentation] Technical issues in stereotactic planning and DBS lead implantation (2019)
  • Author(s): Takashi Morishita and Tooru Inoue
  • Organizer: DBS Think Tank East
  • Int'l Joint Research / Invited
• [Book] Deep Brain Stimulation A Case-Based Approach (2020)
  • Author(s): Sendjaja AN, Morishita T, Inoue T
  • Total Pages: 272
  • Publisher: Oxford University Press
  • ISBN: 9780190647209
• [Remarks] トゥレット症候群に関する研究成果が medRxiv に掲載されました
  • URL: http://www.med.fukuoka-u.ac.jp/neurosur/topics_202010_02.html
• [Funded Workshop] DBS Think Tank East (2019)