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Elucidation of cerebral blood flow autoregulation mechanism by analysis of internal jugular vein blood vascular hormone dynamics during cerebral ischemia and reperfusion

Research Project

Project/Area Number 18K08979
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 56010:Neurosurgery-related
Research InstitutionIwate Medical University

Principal Investigator

Yoshida Kenji  岩手医科大学, 医学部, 特任准教授 (10316367)

Co-Investigator(Kenkyū-buntansha) 小笠原 邦昭  岩手医科大学, 医学部, 教授 (00305989)
Project Period (FY) 2018-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords脳血管反応性 / 過灌流 / 脳虚血再灌流 / 脳血管障害 / 内頸動脈狭窄 / 血管ホルモン / 内頚動脈狭窄 / 脳血流 / 自動調節能
Outline of Final Research Achievements

Comprehensive array analysis was performed on changes in microRNA in the jugular vein as candidates for intraoperative vascular hormones in patients with ischemic events associated with cervical carotid endarterectomy and patients with hyperperfusion. It was confirmed that some microRNAs on miRBase show significant changes immediately after the event.
It is still unclear why hyperperfusion after revascularization also causes higher brain dysfunction. This time, in a prospective study, we found that new microhemorrhages occurred in the brain in patients who showed hyperperfusion after revascularization. It was found to be significantly involved in functional impairment.

Academic Significance and Societal Importance of the Research Achievements

慢性的な虚血性脳血管障害に対して、外科的血行再建術の有意性が証明さているが、脳循環予備能が著しく障害された症例では、術後に過灌流を発生し、新たな認知機能障害や機能・清明予後に関わる重篤な合併症を来すことが大きな問題点であり、過灌流のメカニズムは未だ不明のままであった。今回我々は、術後過灌流メカニズムの解明に寄与するmicroRNAの動態を明らかにした。また、過灌流がなぜ高次脳機能障害をももたらすかについて、脳内に微少出血が発生していること、新規脳内微小出血が、術後認知機能障害に有意に関与していることを明らかにし、過灌流症候群の新たな知見を獲得した。

Report

(6 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (65 results)

All 2023 2022 2021 2020 2019 2018

All Journal Article (24 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 19 results,  Open Access: 8 results) Presentation (41 results) (of which Int'l Joint Research: 4 results)

  • [Journal Article] Prediction of cerebral hyperperfusion following carotid endarterectomy using intravoxel incoherent motion magnetic resonance imaging.2023

    • Author(s)
      Takahashi T, Uwano I, Akamatsu Y, Chida K, Kobayashi M, Yoshida K, Fujiwara S, Kubo Y, Sasaki M, Ogasawara K.
    • Journal Title

      J Stroke Cerebrovasc Dis

      Volume: 32 Issue: 2 Pages: 106909-106909

    • DOI

      10.1016/j.jstrokecerebrovasdis.2022.106909

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Effect of combined Japanese traditional medicines, keishibukuryogan and jidabokuippo, on postoperative soft tissue swelling in adult patients undergoing revascularization surgery for ischemic moyamoya disease: A comparison of two prospective cohort studies.2023

    • Author(s)
      Ogasawara K., *Kawamura T., Kobayashi M., Akamatsu Y., Chida K., Fujiwara S., Yoshida K., Koji T., Kubo Y.
    • Journal Title

      Traditional & Kampo Medicine

      Volume: -

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of cerebral microbleeds and its impact on cognitive function in adult patients receiving medical management alone for ischemic moyamoya disease: supplementary analysis of a 5-year prospective cohort.2022

    • Author(s)
      Yabuki M, Kubo Y, Kitakami K, Oomori D, Fujiwara S, Yoshida K, Kobayashi M, Ogasawara K.
    • Journal Title

      Neurol Res

      Volume: 44 Issue: 12 Pages: 1104-1112

    • DOI

      10.1080/01616412.2022.2112375

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Outcomes of Medical Management Alone for Adult Patients with Cerebral Misery Perfusion Due to Ischemic Moyamoya Disease.2022

    • Author(s)
      Ogasawara K, Uchida S, Akamatsu Y, Chida K, Kobayashi M, Yoshida K, Fujiwara S, Terasaki K, Kubo Y.
    • Journal Title

      J Stroke Cerebrovasc Dis.

      Volume: 31 Issue: 8 Pages: 106588-106588

    • DOI

      10.1016/j.jstrokecerebrovasdis.2022.106588

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] De Novo Cerebral Microbleeds and Cognitive Decline in Cerebral Hyperperfusion After Direct Revascularization for Adult Moyamoya Disease.2022

    • Author(s)
      Dobashi K, Kubo Y, Kimura K, Katakura Y, Chida K, Kobayashi M, Yoshida K, Fujiwara S, Terasaki K, Ogasawara K.
    • Journal Title

      J Stroke Cerebrovasc Dis.

      Volume: 31(1) Issue: 1 Pages: 106166-106166

    • DOI

      10.1016/j.jstrokecerebrovasdis.2021.106166

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Five-Year Outcomes of Medical Management Alone for Adult Patients with Ischemic Moyamoya Disease without Cerebral Misery Perfusion.2022

    • Author(s)
      Kitakami K, Kubo Y, Yabuki M, Oomori D, Takahashi T, Igarashi S, Fujiwara S, Yoshida K, Kobayashi M, Terasaki K, Ogasawara K.
    • Journal Title

      Cerebrovasc Dis.

      Volume: 51(2) Issue: 2 Pages: 158-164

    • DOI

      10.1159/000518725

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Angiographic, Cerebral Hemodynamic, and Cognitive Outcomes of Indirect Revascularization Surgery Alone for Adult Patients With Misery Perfusion due to Ischemic Moyamoya Disease.2021

    • Author(s)
      Kimura K, Kubo Y, Dobashi K, Katakura Y, Chida K, Kobayashi M, Yoshida K, Fujiwara S, Terasaki K, Kawamura T, Ogasawara K.
    • Journal Title

      Neurosurgery

      Volume: 23 Issue: 6 Pages: 676-683

    • DOI

      10.1227/neu.0000000000001907

    • Related Report
      2022 Annual Research Report 2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Angiographic disease progression in medically treated adult patients with ischemic moyamoya disease without cerebral misery perfusion: supplementary analysis of a 5-year prospective cohort.2021

    • Author(s)
      Oomori D, Kubo Y, Yabuki M, Kitakami K, Fujiwara S, Yoshida K, Kobayashi M, Terasaki K, Ogasawara K.
    • Journal Title

      Neurosurg Rev.

      Volume: 23 Issue: 2 Pages: 1553-1561

    • DOI

      10.1007/s10143-021-01677-0

    • Related Report
      2022 Annual Research Report 2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Long-Term Cognitive Changes after Revascularization Surgery in Adult Patients with Ischemic Moyamoya Disease.2021

    • Author(s)
      Uchida S., Kubo Y., Oomori D., Yabuki M., Kitakami K., Fujiwara S., Yoshida K., Kobayashi M., Terasaki K., Ogasawara K.
    • Journal Title

      Cerebrovasc Dis Extra.

      Volume: 11(3) Issue: 3 Pages: 145-154

    • DOI

      10.1159/000521028

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparison of subjective and objective assessments on improvement in gait function after carotid endarterectomy2020

    • Author(s)
      Takahashi T., Fujiwara S., Igarashi S., Ando T., Chida K., Kobayashi M., Yoshida K., Koji T., Kubo Y., Ogasawara K.
    • Journal Title

      Sensors

      Volume: 20(22) Issue: 22 Pages: 6590-6590

    • DOI

      10.3390/s20226590

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Acetazolamide-Loaded Dynamic 7T MR Quantitative Susceptibility Mapping in Major Cerebral Artery Steno-Occlusive Disease: Comparison with PET.2020

    • Author(s)
      Fujimoto K, Uwano I, Sasaki M, Oshida S, Tsutsui S, Yanagihara W, Fujiwara S, Kobayashi M, Kubo Y, Yoshida K, Terasaki K, Ogasawara K
    • Journal Title

      AJNR Am J Neuroradiol

      Volume: in press Issue: 5 Pages: 785-791

    • DOI

      10.3174/ajnr.a6508

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Improvement in gait function after carotid endarterectomy is associated with postoperative recovery in perfusion and neurotransmitter receptor function in the motor-related cerebral cortex: a 123I-iomazenil SPECT study.2020

    • Author(s)
      Sato S., Fujiwara S., Miyoshi K., Chida K., Kobayashi M., Kubo Y., Yoshida K., Terasaki K., Ogasawara K.
    • Journal Title

      Nuclear Medicine Communications.

      Volume: 41(11) Issue: 11 Pages: 1161-1168

    • DOI

      10.1097/mnm.0000000000001275

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Feasibility of IVIM parameters from diffusion-weighted imaging at 11.7T MRI for detecting ischemic changes in common carotid artery occlusion rats.2020

    • Author(s)
      Fujiwara S., *Mori Y., **de la Mora D.M., Akamatsu Y., Yoshida K., *Shibata Y., Masuda T., Ogasawara K., *Yoshioka Y.
    • Journal Title

      SCIENTIFIC REPORTS.

      Volume: 10(1) Issue: 1 Pages: 8404-8404

    • DOI

      10.1038/s41598-020-65310-8

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of the Distal End of Carotid Plaque Using 3-Dimensional Fast Spin Echo T1-Weighted Magnetic Resonance Plaque Imaging.2020

    • Author(s)
      Chida K, Shimada Y, Fujimoto K, Yoshida J, Kojima D, Fujiwara S, Kobayashi M, Yoshida K, Sasaki M, Ogasawara K.
    • Journal Title

      J Stroke Cerebrovasc Dis

      Volume: in press Issue: 4 Pages: 104580-104580

    • DOI

      10.1016/j.jstrokecerebrovasdis.2020.104680

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Revascularisation surgery improves cognition in adult patients with moyamoya disease.2020

    • Author(s)
      Ando T, Shimada Y, Fujiwara S, Yoshida K, Kobayashi M, Kubo Y, Terasaki K, Ando S, Ogasawara K.
    • Journal Title

      J Neurol Neurosurg Psychiatry

      Volume: 91 Issue: 3 Pages: 332-334

    • DOI

      10.1136/jnnp-2019-321069

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Adverse effects of pre-existing cerebral small vessel disease on cognitive improvement after carotid endarterectomy2019

    • Author(s)
      Yoshida J., Yamashita F., Sasaki M., Yoshioka K., Fujiwara S., Kobayashi M., Yoshida K., Kubo Y., Ogasawara K.
    • Journal Title

      International Journal of Stroke

      Volume: - Issue: 6 Pages: 657-556

    • DOI

      10.1177/1747493019874732

    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] 合併症減少のために必要なモニタリングは?2019

    • Author(s)
      千田光平、小笠原邦昭
    • Journal Title

      脳神経外科速報

      Volume: 2019年増刊 Pages: 139-139

    • Related Report
      2019 Research-status Report
  • [Journal Article] 血管縫合の際の注意点は?術後出血の予防法は?2019

    • Author(s)
      千田光平、小笠原邦昭
    • Journal Title

      脳神経外科速報

      Volume: 2019年増刊 Pages: 138-138

    • Related Report
      2019 Research-status Report
  • [Journal Article] 頚動脈の遮断および解除の順番は?2019

    • Author(s)
      千田光平、小笠原邦昭
    • Journal Title

      脳神経外科速報

      Volume: 2019年増刊 Pages: 137-137

    • Related Report
      2019 Research-status Report
  • [Journal Article] 内膜剥離のポイントは?性状での違いは?断端形成のは?閉塞の予防法は?2019

    • Author(s)
      千田光平、小笠原邦昭
    • Journal Title

      脳神経外科速報

      Volume: 2019年増刊 Pages: 136-136

    • Related Report
      2019 Research-status Report
  • [Journal Article] 6章脳血管障害 3.頚動脈内膜剥離術 Hyperperfusionの予防および対策は?2019

    • Author(s)
      千田光平、小笠原邦昭
    • Journal Title

      脳神経外科速報

      Volume: 2019年増刊 Pages: 135-135

    • Related Report
      2019 Research-status Report
  • [Journal Article] Impact of external carotid artery occlusion at declamping of the external and common carotid arteries during carotid endarterectomy on development of new postoperative ischemic cerebral lesions.2019

    • Author(s)
      Kobayashi M., Yoshida K., Kojima D., Oshida S., Fujiwara S., Kubo Y., Ogasawara K.
    • Journal Title

      J Vasc Surg.

      Volume: 69(2) Issue: 2 Pages: 454-461

    • DOI

      10.1016/j.jvs.2018.03.437

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Reduced hypoxic tissue and cognitive improvement after revascularization surgery for chronic cerebral ischemia.2019

    • Author(s)
      Shimada Y, Kobayashi M, Yoshida K, Terasaki K, Fujiwara S, Kubo Y, Beppu T, Ogasawara K.
    • Journal Title

      Cerebrovasc Dis.

      Volume: 47 Issue: 1-2 Pages: 57-64

    • DOI

      10.1159/000497244

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Preoperative brain temperature imaging on proton magnetic resonance spectroscopy predicts hemispheric ischemia during carotid endarterectomy for unilateral carotid stenosis with inadequate collateral blood flow2018

    • Author(s)
      Tsutsui Shouta、Nanba Takamasa、Yoshioka Yoshichika、Sasaki Makoto、Fujiwara Shunrou、Kobayashi Masakazu、Yoshida Kenji、Miyoshi Kenya、Sato Shinpei、Ogasawara Kuniaki
    • Journal Title

      Neurological Research

      Volume: 印刷中 Pages: 1-7

    • DOI

      10.1080/01616412.2018.1457130

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] IVIM MRI画像から得られたCBVによる頚動脈内膜剥離術後過灌流の術前予知2023

    • Author(s)
      高橋達彦、上野育子、赤松洋祐、千田光平、小林正和、吉田研二、藤原俊朗、久保慶高、佐々木真理、小笠原邦昭
    • Organizer
      STROKE2023(第48回日本脳卒中学会学術集会)
    • Related Report
      2022 Annual Research Report
  • [Presentation] 貧困灌流のない成人虚血発症もやもや病に対する薬物療法の臨床、脳循環、認知機能の5年転帰2022

    • Author(s)
      小林正和、北上 慧、矢吹昌広、大森大輔、高橋達彦、五十嵐傑、千田光平、藤原俊朗、吉田研二、久保慶高、小笠原邦昭
    • Organizer
      第65回日本脳循環代謝学会学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 脳に埋没した中大脳動脈末梢部動脈瘤へのICG Flash fluorescence法を用いたtarget bypass2022

    • Author(s)
      千葉貴之、久保慶高、佐藤慎平、村上寿孝、赤松洋祐、千田光平、幸治孝裕、吉田研二、小笠原邦昭
    • Organizer
      (一社)日本脳神経外科学会第81回学術総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 頚動脈内膜剥離術による認知機能および運動機能の改善とそのメカニズム2022

    • Author(s)
      千田光平、藤原俊朗、小林正和、吉田研二、寺崎一典、小笠原邦昭
    • Organizer
      (一社)日本脳神経外科学会第81回学術総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 貧困灌流をもつ出血発症もやもや病に対し間接血行再建術単独を行いperiventricular anastomosisが消退した1例2022

    • Author(s)
      北上 慧、千田光平、矢吹昌広、高橋達彦、小林正和、吉田研二、小笠原邦昭
    • Organizer
      第63回(一社)日本脳神経外科学会東北支部会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 貧困灌流を呈する虚血発症成人もやもや病に対する間接血行再建術単独による脳循環および認知機能の変化2022

    • Author(s)
      千田光平、土橋一正、木村和人、柳原 普、藤原俊朗、小林正和、吉田研二、寺崎一典、小笠原邦昭
    • Organizer
      第31回東北脳SPECT研究会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 頚動脈プラーク Superb micro-vascular imaging 法による内膜剥離術中 微小塞栓出現の予知2022

    • Author(s)
      千葉貴之、藤原俊朗、大浦一雅、及川公樹、千田光平、小林正和、吉田研二、久保慶高、前田哲也、板橋 亮、小笠原邦昭
    • Organizer
      CVSS2022 (第9回日本心血管脳卒中学会学術集会)
    • Related Report
      2022 Annual Research Report
  • [Presentation] ICG Flash fiuorescence法によるtraget baypassを用いた脳動脈瘤の1例2022

    • Author(s)
      千葉貴之、久保慶高、佐藤慎平、村上寿孝、赤松洋祐、千田光平、幸治孝裕、吉田研二、小笠原邦昭
    • Organizer
      第31回脳神経外科手術と機器学会 (CNTT2022)
    • Related Report
      2022 Annual Research Report
  • [Presentation] 成人虚血発症もやもや病における MRI Hadamard ASL を用いた脳循環不全の検出2021

    • Author(s)
      攝田典悟、松田 豪、佐々木真理、千葉貴之、藤原俊朗、小林正和、吉田研二、久保慶高、鈴木美知子、吉岡邦浩、小笠原邦昭
    • Organizer
      第64回日本脳循環代謝学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] 頚動脈プラーク Superb micro-vascular imaging 法による内膜剥離術中微小塞栓出現の予知2021

    • Author(s)
      千葉貴之、藤原俊朗、大浦一雅、及川公樹、千田光平、小林正和、吉田研二、久保慶高、前田哲也、板橋 亮、小笠原邦昭
    • Organizer
      第64回日本脳循環代謝学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] SMIを用いた頚動脈内膜剥離術における頚動脈露出操作 中の経頭蓋ドップラー上微小塞栓出現の予知2021

    • Author(s)
      千葉貴之、藤原俊朗、大浦一雅、及川公樹、千田光平、小林正和、吉田研二、久保慶高、前田哲也、板橋 亮、小笠原邦昭
    • Organizer
      (一社)日本脳神経外科学会第80回学術総会
    • Related Report
      2021 Research-status Report
  • [Presentation] 成人虚血発症もやもや病におけるMRI Hadamard ASL を用いた脳循環不全の検出2021

    • Author(s)
      攝田典悟、松田 豪、佐々木真理、千葉貴之、藤原俊朗、小林正和、吉田研二、久保慶高、鈴木美知子、吉岡邦浩、小笠原邦昭
    • Organizer
      (一社)日本脳神経外科学会第80回学術総会
    • Related Report
      2021 Research-status Report
  • [Presentation] 成人虚血発症もやもや病におけるMRI Hadamard ASLを用いた脳循環不全の検出2021

    • Author(s)
      攝田典悟、松田 豪、佐々木真理、千葉貴之、藤原俊朗、小林正和、吉田研二、久保慶高、鈴木美知子、吉岡邦浩、小笠原邦昭
    • Organizer
      第30回東北脳SPECT研究会
    • Related Report
      2021 Research-status Report
  • [Presentation] Detection of cerebral hypoperfusion using Hadamard- encoded ASL in adult moyamoya disease2021

    • Author(s)
      攝田典悟、松田 豪、藤原俊朗、千葉貴之、小林正和、吉田研二、久保慶高、吉岡邦浩、佐々木真理、小笠原邦昭
    • Organizer
      第39回 The Mt.Fuji Workshop on CVD
    • Related Report
      2021 Research-status Report
  • [Presentation] 成人虚血発症もやもや病における直接血行再建術後認知機能変化のメカニズム2021

    • Author(s)
      千田光平、柳原 普、島田泰良、小林正和、吉田研二、久保慶高、寺崎一典
    • Organizer
      第39回 The Mt.Fuji Workshop on CVD
    • Related Report
      2021 Research-status Report
  • [Presentation] 貧困灌流のない成人虚血発症もやもや病に対する薬物療法の臨床、脳循環、認知機能の2年転帰2021

    • Author(s)
      小林正和、千田光平、吉田研二、久保慶高、小笠原邦昭
    • Organizer
      第39回 The Mt.Fuji Workshop on CVD
    • Related Report
      2021 Research-status Report
  • [Presentation] SMI 法を用いた術前頚動脈超音波検査による内膜剥離術中の微小塞栓出現の予知2021

    • Author(s)
      千葉貴之、藤原俊朗、大浦一雅、攝田典悟、千田光平、小林正和、吉田研二、久保慶高、前田哲也、小笠原邦昭
    • Organizer
      第44回日本脳神経CI学会総会
    • Related Report
      2021 Research-status Report
  • [Presentation] 大志田創太郎、森 太志、小林正和、吉田研二、藤原俊朗、佐々木真理、小笠原邦昭2021

    • Author(s)
      数値流体力学解析を用いた内頚動脈内膜剥離術における術中微小塞栓出現の術前予測
    • Organizer
      第44回日本脳神経CI学会総会
    • Related Report
      2021 Research-status Report
  • [Presentation] 頚動脈内膜剥離術後の歩行機能改善:運動関連皮質の灌流および神経受容体機能との関連2021

    • Author(s)
      佐藤慎平、藤原俊朗、三善健矢、千田光平、小林正和、久保慶高、吉田研二、寺崎一典、小笠原邦昭
    • Organizer
      第44回日本脳神経CI学会総会
    • Related Report
      2021 Research-status Report
  • [Presentation] 成人虚血発症もやもや病における MRI Hadamard ASL を用いた脳循環不全の検出2021

    • Author(s)
      攝田典悟、松田 豪、千田光平、小林正和、吉田研二、藤原俊朗、千葉貴之、佐々木真理、小笠原邦昭
    • Organizer
      第44回日本脳神経CI学会総会
    • Related Report
      2021 Research-status Report
  • [Presentation] 頚動脈内膜剥離術後の歩行機能の改善は運動関連大脳皮質における灌流および神経受容体機能の術後回復と関連する2021

    • Author(s)
      佐藤慎平、藤原俊朗、三善健矢、千田光平、小林正和、久保慶高、吉田研二、寺崎一典、小笠原邦昭
    • Organizer
      脳循環代謝サマーキャンプ2021
    • Related Report
      2021 Research-status Report
  • [Presentation] 超高磁場11.7TMRI拡散強調像に基づくIVIMパラメータを用いた両側総頚動脈閉塞ラット脳虚血変化の検出2021

    • Author(s)
      藤原俊朗、森 勇樹、*ダニエラ デゥラモラ、赤松洋祐、吉田研二、柴田祐二、増田智之、小笠原邦昭、*吉岡吉親
    • Organizer
      STROKE2021 (第46回日本脳卒中学会学術集会)
    • Related Report
      2020 Research-status Report
  • [Presentation] 成人虚血発症モヤモヤ病におけるMRI Hadamard ASLを用いた脳循環不全の検出2021

    • Author(s)
      攝田典悟、松田 豪、上野育子、千田光平、小林正和、吉田研二、藤原俊朗、千葉貴之、久保慶高、佐々木真理、小笠原邦昭
    • Organizer
      STROKE2021 (第46回日本脳卒中学会学術集会)
    • Related Report
      2020 Research-status Report
  • [Presentation] 頚動脈プラークSuperb micro-vascular imaging法による内膜剥離術中微小塞栓出現の予知2021

    • Author(s)
      千葉貴之、藤原俊朗、大浦一雅、前川哲郎、攝田典悟、千田光平、小林正和、吉田研二、久保慶高、前田哲也、小笠原邦昭
    • Organizer
      STROKE2021 (第46回日本脳卒中学会学術集会)
    • Related Report
      2020 Research-status Report
  • [Presentation] 頚動脈内膜剥離術後の歩行機能改善:運動関連大脳皮質における灌流および神経受容体機能との関連2020

    • Author(s)
      佐藤慎平、藤原俊朗、三善健矢、千田光平、小林正和、久保慶高、吉田研二、寺崎一典、小笠原邦昭
    • Organizer
      第63回日本脳循環代謝学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] 動物用11.7TMRIを用いた段階的両側総頚動脈閉塞ラットにおける生体内動態変化の計測2020

    • Author(s)
      藤原俊朗、*森 勇樹、*Daniela Martinez de la Mora、赤松洋祐、吉田研二、柴田祐二、増田友之、小笠原邦昭、*吉岡芳親
    • Organizer
      第63回日本脳循環代謝学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] 動物用11.7TMIにおけるIVIMパラメータを用いた両側総頚動脈閉塞ラットにおける脳虚血変化の検出2020

    • Author(s)
      藤原俊朗、*森 勇樹、*Daniela Martinez de la Mora、赤松洋祐、吉田研二、柴田祐二、増田友之、小笠原邦昭、*吉岡芳親
    • Organizer
      (一社)日本脳神経外科学会第79回学術総会
    • Related Report
      2020 Research-status Report
  • [Presentation] 動物用11.7TMIにおけるIVIMパラメータを用いた段階的両側総頚動脈閉塞ラット脳虚血部位の推定2020

    • Author(s)
      藤原俊朗、*森 勇樹、*Daniela Martinez de la Mora、赤松洋祐、吉田研二、柴田祐二、増田友之、小笠原邦昭、*吉岡芳親
    • Organizer
      第48回日本磁気共鳴医学会大会
    • Related Report
      2020 Research-status Report
  • [Presentation] MR Plaque Imagingによる頚動脈内膜剥離術前のプラーク遠位端の同定2020

    • Author(s)
      千田光平、島田泰良、藤本健太郎、吉田 純、小島大吾、藤原俊朗、小林正和、吉田研二、佐々木真理、小笠原邦昭
    • Organizer
      STROKE2020(第45回日本脳卒中学会学術集会)
    • Related Report
      2020 Research-status Report
  • [Presentation] 頚動脈内膜剥離述後の運動機能の改善は運動関連皮質神経受容体機能の改善と関連する2020

    • Author(s)
      佐藤慎平、藤原俊朗、三善健矢、千葉貴之、攝田典悟、千田光平、吉田研二、小林正和、久保慶高、小笠原邦昭
    • Organizer
      STROKE2020(第45回日本脳卒中学会学術集会)
    • Related Report
      2020 Research-status Report
  • [Presentation] MR Plaque Imaging による頚動脈内膜剥離術前のプラーク遠位端の同定2019

    • Author(s)
      千田光平、島田泰良、藤本健太郎、吉田 純、小島大吾、藤原俊朗、小林正和、吉田研二、佐々木真理、小笠原邦昭
    • Organizer
      第6回日本心血管脳卒中学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] 慢性脳虚血に対する血行再建術後の“低酸素環境下生存脳組織”の消失は認知機能改 善と関連しているか?2019

    • Author(s)
      島田泰良、小林正和、吉田研二、寺崎一典、藤原俊朗、久保慶高、別府高明、小笠原邦昭
    • Organizer
      第6回日本心血管脳卒中学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] 大脳小動脈病変の術前存在は頸動脈内膜剥離術後の認知機能改善を抑制する2019

    • Author(s)
      吉田 純、山下典生、佐々木真理、吉岡邦浩、藤原俊朗、小林正和、吉田研二、久保慶高、小笠原邦昭
    • Organizer
      第6回日本心血管脳卒中学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] CEAと脳神経超音波検査2019

    • Author(s)
      小林正和、佐藤慎平、三善健矢、千葉貴之、千田光平、吉田研二、藤原俊朗、小笠原邦昭
    • Organizer
      第38回日本脳神経超音波学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] Reduced hypoxic tissue and cognitive improvement after revascularization surgery for chronic cerebral ischemia2019

    • Author(s)
      Shimada Y., Kobayashi M., Yoshida K., Terasaki K., Fujiwara S., Kubo Y., Beppu T., Ogasawara K.
    • Organizer
      BRAIN & BRAIN PET 2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Cerebral white matter abnormalities can affect cognitive improvement after carotid endarterectomy in patients with carotid artery steno-occlusive disease2019

    • Author(s)
      Yoshida J., Yamashita F., SasakiM., Yoshioka Y., Fujiwara S., Kobayashi M., Yoshida K., Kubo Y., Ogasawara K.
    • Organizer
      Computer Assisted Radiology and Surgery(CARS)2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Cerebral hyperperfusion-related inhibit of development of cerebral ischemic lesions after revascularization due to artery-to-artery emboli during carotid exposure in endarterectomy for patients chronic ischemia2019

    • Author(s)
      Fujimoto K., Matsumoto Y., Oikawa K., Nomura J., Shimada Y., Fujiwara S., Terasaki K., Kobayashi M., Yoshida K., Ogasawara K.
    • Organizer
      5th European Stroke Organization Conference (ESOC 2019)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Relation between reduction of hypoxic tissue and cognitive improvement after revascularization surgery in patients with chronic cerebral ischemia2019

    • Author(s)
      Shimada Y., Kobayashi1 M., Yoshida K., Terasaki K., Fujiwara S., Kubo Y,, Beppu T., Ogasawara K.
    • Organizer
      5th European Stroke Organization Conference (ESOC 2019)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 大脳細動脈病変の術前存在は頸動脈内膜剥離術後の認知機能改善を阻止する2019

    • Author(s)
      吉田 純、佐々木真理、吉岡邦浩、小林正和、吉田研二、久保慶高、小笠原邦昭
    • Organizer
      STROKE2019(第44回日本脳卒中学会学術集会)
    • Related Report
      2018 Research-status Report
  • [Presentation] 慢性脳虚血に対する血行再建術後の“低酸素環境下生存脳組織”の消失は認知機能改善と関連しているか?2019

    • Author(s)
      島田泰良、小林正和、吉田研二、寺崎一典、藤原俊朗、久保慶高、別府高明、小笠原邦昭
    • Organizer
      STROKE2019(第44回日本脳卒中学会学術集会)
    • Related Report
      2018 Research-status Report
  • [Presentation] 定量的磁化率強調画像上もアセタゾラマイド負荷直後の脳血流変化を用いた血行力学的脳虚血の重症度検出2019

    • Author(s)
      藤本健太郎、藤原俊朗、上野育子、島田泰良、吉田 純、大志田創太郎、小島大吾、野村順一、小林正和、佐々木真理、小笠原邦昭
    • Organizer
      STROKE2019(第44回日本脳卒中学会学術集会)
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2024-01-30  

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