| Project/Area Number |
18K08982
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 56010:Neurosurgery-related
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| Research Institution | Meiji University of Integrative Medicine |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
梅田 雅宏 明治国際医療大学, 医学教育研究センター, 教授 (60223608)
田中 忠蔵 明治国際医療大学, 医学教育研究センター, 名誉教授 (80163541)
渡邉 康晴 明治国際医療大学, 医学教育研究センター, 准教授 (90454537)
河合 裕子 明治国際医療大学, 医学教育研究センター, 助教 (90555616)
萬代 綾子 明治国際医療大学, 臨床医学講座, 助教 (20769343)
村瀬 智一 明治国際医療大学, 医学教育研究センター, 客員助教 (00708943)
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| Project Period (FY) |
2018-04-01 – 2024-03-31
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| Project Status |
Completed (Fiscal Year 2023)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | MRI / glymphatic system / fMRI / ADC / 熱刺激 / グリンパティックシステム / MRS / 酸化ストレス / 脳代謝 / 神経疾患 |
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| Outline of Final Research Achievements |
It has been revealed that the glymphatic system plays an important role in the transport and clearance of water and metabolic substrates in brain tissue. Dysfunction of this system has been reported to cause Alzheimer's disease, traumatic brain injury, and hydrocephalus, and it has also been implicated in Parkinson's disease and ALS. Focusing on the perivascular Virchow-Robin spaces, the movement of cerebrospinal fluid within the brain was measured. The velocity of cerebrospinal fluid movement was triggered by pulse waves, and the pulsations of arteries near the region of interest were observed. Diffusion-weighted imaging was used to calculate ADC in two phases. For the evaluation of neural tissue, neuroamino acids were measured using MRS, and their metabolic maps were utilized for assessment. Additionally, brain functional activity was evaluated with fMRI. Methodological and technical improvements were achieved, such as the separation and identification of spectra.
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| Academic Significance and Societal Importance of the Research Achievements |
β-amyloidやタウ蛋白、α-synucleinなどの脳内異常蓄積が種々の神経疾患の原因となることは知られていたが、代謝異常ではなくグリンパティックシステムの機能異常に起因する物質の排泄障害が原因となるという新たな概念が導入され、パーキンソン病、ALSとの関連も指摘されている。非侵襲的に画像評価や機能評価が可能なMRIはグリンパティックシステムの異常のような急激な組織変化を伴わない機能的変化を検出するにあたって有用な技術であり、病態解析を行うことができる評価方法の確立が望まれる。
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