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Metabolomic biomarkers to diagnose primary CNS lymphoma

Research Project

Project/Area Number 18K08995
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 56010:Neurosurgery-related
Research InstitutionKobe University

Principal Investigator

Mizukawa Katsu  神戸大学, 医学部附属病院, 非常勤講師 (80403260)

Co-Investigator(Kenkyū-buntansha) 篠山 隆司  神戸大学, 医学部附属病院, 教授 (10379399)
甲村 英二  神戸大学, 医学研究科, 名誉教授 (30225388)
田中 一寛  神戸大学, 医学研究科, 講師 (70467661)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords原発性中枢性リンパ腫 / バイオマーカー / 原発性中枢神経リンパ腫 / メタボローム解析 / CXCL13 / myo-inositol / MYD88 / 代謝リモデリング
Outline of Final Research Achievements

Tumor biopsy is essential for the definitive diagnosis of central nervous system (CNS) lymphoma. However, the biopsy procedure carries the risk of complications such as bleeding, convulsions, and infection. We established a multi-marker diagnostic model using the C-X-C motif chemokine ligand 13 (CXCL13), interleukin-10 (IL-10), β2-microglobulin (β2-MG), and soluble IL-2 receptor (sIL-2R)in cerebrospinal fluid (CSF). In addition, CSF CXCL13 was a prognostic biomarker for CNS lymphoma patients. Our study suggests that multi-marker algorithms are important diagnostic tools for patients with CNS lymphoma.

Academic Significance and Societal Importance of the Research Achievements

PCNSLの診断法のgold standardは生検術による組織診断であり、通常は組織診断確定によ
り放射線治療や化学療法が開始となる。sIL-2 レセプターやbeta2-microglobulinなどの髄液バイオマーカーは術前診断の決定の一助となる。今回、メタボローム解析による術前診断に有用な代謝物の同定には至らなかったが、IL-10やCXCL13などの新たな髄液バイオマーカーを前述のマーカーに組み合わせることによって高い精度の診断アルゴリズムを開発した。今後はPCNSLの術前診断に加えて治療効果の判定や再発の予知などにも応用できると考えられ、当研究の臨床的意義は非常に高いと思われる。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (5 results)

All 2020 2019 2018 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (1 results) Remarks (1 results)

  • [Journal Article] Multi-marker algorithms based on CXCL13, IL-10, sIL-2 receptor, and β2-microglobulin in cerebrospinal fluid to diagnose CNS lymphoma.2020

    • Author(s)
      Maeyama M, Sasayama T, Tanaka K, Nakamizo S, Tanaka H, Nishihara M, Fujita Y, Sekiguchi K, Kohta M, Mizukawa K, Hirose T, Itoh T, Kohmura E.
    • Journal Title

      Cancer Med

      Volume: 9 Issue: 12 Pages: 3048-3048

    • DOI

      10.1002/cam4.3048

    • NAID

      120006863597

    • Related Report
      2020 Annual Research Report 2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] MicroRNA regulating stanniocalcin-1 is a metastasis and dissemination promoting factor in glioblastoma2019

    • Author(s)
      Sakata Junichi、Sasayama Takashi、Tanaka Kazuhiro、Nagashima Hiroaki、Nakada Mitsutoshi、Tanaka Hirotomo、Hashimoto Naoya、Kagawa Naoki、Kinoshita Manabu、Nakamizo Satoshi、Maeyama Masahiro、Nishihara Masamitsu、Hosoda Kohkichi、Kohmura Eiji
    • Journal Title

      Journal of Neuro-Oncology

      Volume: 142 Issue: 2 Pages: 241-251

    • DOI

      10.1007/s11060-019-03113-2

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Embryonal brain tumor with unknown primary lesion and massive cerebrospinal fluid dissemination: A case report.2018

    • Author(s)
      Tanaka H, Yamamoto D, Ikeda M, Morikawa M, Ueda K, Tanaka K, Sasayama T, Kohmura E.
    • Journal Title

      J Clin Neurosci.

      Volume: 54 Pages: 125-128

    • DOI

      10.1016/j.jocn.2018.04.046

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] 初発中枢神経悪性リンパ腫(PCNSL)に対するR-MPV療法の安全性と有用性について2020

    • Author(s)
      篠山隆司、田中一寛、藤田祐一、橋口充、前山昌博
    • Organizer
      第38回日本脳腫瘍学会
    • Related Report
      2020 Annual Research Report
  • [Remarks] ホーム > 研究 > 脳腫瘍

    • URL

      https://www.med.kobe-u.ac.jp/neuro/study/brain-tumor.html

    • Related Report
      2020 Annual Research Report

URL: 

Published: 2018-04-23   Modified: 2022-01-27  

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