| Project/Area Number |
18K08998
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Review Section |
Basic Section 56010:Neurosurgery-related
|
|---|
| Research Institution | Saga University |
|---|
Principal Investigator |
Abe Tatsuya 佐賀大学, 医学部, 教授 (40281216)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
増岡 淳 佐賀大学, 医学部, 准教授 (50359949)
中原 由紀子 佐賀大学, 医学部, 講師 (50380770)
|
|---|
| Project Period (FY) |
2018-04-01 – 2021-03-31
|
| Project Status |
Completed (Fiscal Year 2020)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | 脳腫瘍 / 遺伝子 / 治療 / 微小環境制御 / 幹細胞 / precision medicine / 非対称分裂 / NDRG1 / 分子標的治療 / 腫瘍幹細胞 / 分子標的薬 / 微小環境 |
|---|
| Outline of Final Research Achievements |
Malignant glioma showed treatment resistance due to various factors including hypoxic microenvironment and glioma stem cells. We isolated glioma stem cells in patients with glioblastoma (GBM) and examined the genetic changes under hypoxic condition. We found the gaining diversity under microenvironment and possible novel mechanism to utilize microenvironment in glioma stem cells. Above all, we examined both molecular mechanism of asymmetric cell division in glioma stem cells and NDRG1-dependent antitumor effects, suggesting the clinical benefits of NDRG1-targeted therapeutics against GBM.
|
| Academic Significance and Societal Importance of the Research Achievements |
悪性脳腫瘍は予後不良な疾患である。これまで様々な治療が行われてきたが、極めて治療抵抗性である。そこで、我々は腫瘍幹細胞株を単離・樹立していく過程で、NDRG1遺伝子に着目し研究を推進させた。この遺伝子は膠芽腫の予後を左右する因子でありこれまでにない切り口での治療法開発に結び付く可能性を見出せたことは、将来の治療発展に新展開をもたらすことが期待でき、学術的意義は極めて高いと考えられる。
|
