Elucidation of relationship between Alzheimer disease and dementia due to cerebral hemodynamic insufficiency using carotid endarterectomy
| Project/Area Number |
18K09002
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 56010:Neurosurgery-related
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| Research Institution | Iwate Medical University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | アミロイド / アルツハイマー病 / 頸動脈狭窄 / 頸動脈内膜剥離術 / 認知機能 / PET / 脳循環不全 / 頚動脈内膜剥離術 / 脳循環代謝 / 頚動脈狭窄 / 血行再建 / 脳循環 / 脳循環不全性認知症 |
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| Outline of Final Research Achievements |
Patients with carotid endarterectomy underwent amyloid β (F-florbetapir) and 15O gas PET. As a result, F-florbetapir PET depicted amyloid β deposition as decreased tracer uptake in the cerebral regions where cerebral blood flow and cerebral metabolic rate of oxygen were reduced and oxygen extraction fraction was elevated. In addition, chronic cerebral hypoperfusion due to severe atherosclerotic stenosis of the internal carotid artery does not increase amyloid β deposition in the affected cerebral hemisphere, but correction of cerebral hypoperfusion after carotid endarterectomy often reduces amyloid β deposition.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究のリサーチクエスチョンである「「頚動脈狭窄による脳循環不全が脳からのアミロイドの排出を阻害し、沈着したアミロイドが認知機能障害をきたす。また、その可逆性をヒトで検証する。」に関し、前半はこの検討を行うのに、アミロイドＰＥＴを行うことは必ずしも適していないことが示唆された。後半は、「頚動脈狭窄による脳循環不全の改善認知機能が改善する」メカニズムは、アルツハイマー病で沈着するアミロイドの洗い出しであることが示された。このことから脳循環を改善することによりアルツハイマー病は症状改善をもたらすのではないかというこれまでの仮説をうらずける結果と思われる。
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Report
(4 results)
Research Products
(36 results)
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[Journal Article] Acetazolamide-Loaded Dynamic 7T MR Quantitative Susceptibility Mapping in Major Cerebral Artery Steno-Occlusive Disease: Comparison with PET.2020
Author(s)
Fujimoto K, Uwano I, Sasaki M, Oshida S, Tsutsui S, Yanagihara W, Fujiwara S, Kobayashi M, Kubo Y, Yoshida K, Terasaki K, Ogasawara K
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Journal Title
AJNR Am J Neuroradiol
Volume: in press
Issue: 5
Pages: 785-791
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Comparison of effects between clopidogrel and cilostazol on cerebral perfusion in nonsurgical adult patients with symptomatically ischemic moyamoya disease: subanalysis of a prospective cohort.2018
Author(s)
Chiba T, Setta K, Shimada Y, Yoshida J, Fujimoto K, Tsutsui S, Yoshida K, Kobayashi M, Kubo Y, Fujiwara S, Terasaki K, Ogasawara K.
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Journal Title
J Stroke Cerebrovasc Dis.
Volume: 27
Issue: 11
Pages: 3373-3379
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Accuracy of brain perfusion single-photon emission computed tomography for detecting misery perfusion in adult patients with symptomatic ischemic moyamoya disease.2018
Author(s)
Setta K, Kojima D, Shimada Y, Yoshida J, Oshida S, Fujimoto K, Tsutsui S, Chiba T, Fujiwara S, Terasaki K, Ogasawara K.
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Journal Title
Ann Nucl Med.
Volume: 32
Issue: 9
Pages: 611-619
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Preoperatively reduced cerebrovascular contractile reactivity to hypocapnia by hyperventilation is associated with cerebral hyperperfusion syndrome after arterial bypass surgery for adult patients with cerebral misery perfusion due to ischemic moyamoya disease.2018
Author(s)
Sato S, Kojima D, Shimada Y, Yoshida J, Fujimato K, Fujiwara S, Kobayashi M, Kubo Y, Yoshida K, Terasaki K, Tsutsui S, Miyoshi K, Ogasawara K.
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Journal Title
J Cereb Blood Flow Metab
Volume: 1
Issue: 6
Pages: 1021-1031
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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