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Functional MRI and diffusion MRI analysis of motor function plasticity and networks utilizing machine learning.

Research Project

Project/Area Number 18K09005
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 56010:Neurosurgery-related
Research InstitutionJuntendo University

Principal Investigator

TANGE YUICHI  順天堂大学, 医学部, 准教授 (60296853)

Co-Investigator(Kenkyū-buntansha) 和気 秀文  順天堂大学, スポーツ健康科学部, 教授 (50274957)
中島 円  順天堂大学, 医学部, 准教授 (50317450)
新井 一  順天堂大学, 医学部, 教授 (70167229)
田中 聡久  東京農工大学, 工学(系)研究科(研究院), 教授 (70360584)
菅野 秀宣  順天堂大学, 医学部, 先任准教授 (90265992)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords脳可塑性 / MRI / VolBM / MTsat / TBSS / brain machine interface / Brain plasticity / 拡散MRI / 機能MRI / 機械学習 / 神経可塑性
Outline of Final Research Achievements

This study aimed to evaluate the correlation between world-class gymnasts (WCGs)’ specific abilities in different gymnastics events and their gray matter (GM) volume. Volume-based morphometry (VolBM) was used to compare GM volume differences between WCGs and controls. Significantly higher GM volumes (false discovery rate-corrected p < 0.05) in the inferior parietal lobule, middle temporal gyrus, precentral gyrus, rostral middle frontal gyrus, and superior frontal gyrus were demonstrated in WCGs, compared with controls using VolBM. Moreover, significant positive correlations were observed between brain regions and the difficulty scores for each gymnastic event, for example, rings and inferior parietal lobule and parallel bars and rostral middle frontal gyrus. These results may reflect the neural basis of an outstanding gymnastic ability resulting from brain plasticity in areas associated with spatial perception, vision, working memory, and motor control.

Academic Significance and Societal Importance of the Research Achievements

運動機能に長けたアスリートにおける運動関連タスクにより、脳の賦活部位は縮小かつ効率化されうるというneural efficient hypothesisを実践し、機能と構造を融合させた総合的なメカニズムを解明した。これにより、運動機能の可塑性促進部位およびネットワークが特定され、積極的な脳神経外科手術の実践や治療成績向上に寄与すること可能となり得ると考えられる。また、人工知能機能を付加したBrain machine interfaceへの応用に結び付け、脳卒中等により運動機能を喪失した患者に対するテーラーメイド・リハビリテーションの実現に寄与する。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (7 results)

All 2020 2018

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (5 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Regional brain gray matter volume in world-class artistic gymnasts2020

    • Author(s)
      Fukuo Makoto、Kamagata Koji、Kuramochi Mana、Andica Christina、Tomita Hiroyuki、Waki Hidefumi、Sugano Hidenori、Tange Yuichi、Mitsuhashi Takumi、Uchida Wataru、Takenaka Yuki、Hagiwara Akifumi、Harada Mutsumi、Goto Masami、Hori Masaaki、Aoki Shigeki、Naito Hisashi
    • Journal Title

      The Journal of Physiological Sciences

      Volume: 70 Issue: 1 Pages: 43-50

    • DOI

      10.1186/s12576-020-00767-w

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Functional MRI and Structural Connectome Analysis of Language Networks in Japanese-English Bilinguals2020

    • Author(s)
      Mitsuhashi Takumi、Sugano Hidenori、Asano Keiko、Nakajima Takayuki、Nakajima Madoka、Okura Hidehiro、Iimura Yasushi、Suzuki Hiroharu、Tange Yuichi、Tanaka Toshihisa、Aoki Shigeki、Arai Hajime
    • Journal Title

      Neuroscience

      Volume: 431 Pages: 17-24

    • DOI

      10.1016/j.neuroscience.2020.01.030

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] functional MRI, diffusion MRIによる小児期の言語可塑性関与領域及びネットワー クの検討2018

    • Author(s)
      三橋匠、菅野秀宣、中島円、肥後拓磨、飯村康司、鈴木皓晴、新井一、浅野恵子、中嶋高幸、田中聡久
    • Organizer
      第60回日本小児神経学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] Functional MRI及びConnectomeによる言語可塑性関連領域及びネットワークの解析2018

    • Author(s)
      三橋匠、菅野秀宣、中島円、肥後拓磨、飯村康司、鈴木皓晴、新井一、浅野恵子
    • Organizer
      第48回日本臨床神経生理学会
    • Related Report
      2018 Research-status Report
  • [Presentation] Functional MRI and Structural Connectome Mapping Analysis of Language Networks in Japanese-English Bilinguals2018

    • Author(s)
      川村海渡、菅野秀宣、中島円、肥後拓磨、飯村康司、鈴木皓晴、三橋匠、新井一、浅野恵子
    • Organizer
      2018 American Epilepsy Society Annual meeting
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 世界トップレベルの体操競技選手の長期間のトレーニングによる脳灰白質体積:正常対照群との比較2018

    • Author(s)
      倉持麻奈、鎌形康司、アンディカ クリスティナ、冨田洋之、武中祐樹、萩原彰文、福尾誠、原田睦巳、和気秀文、内藤久士、青木茂樹
    • Organizer
      第46回日本磁気共鳴医学会大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Multi-shell DWIを用いた世界的な体操競技選手のコネクトーム解析の検討2018

    • Author(s)
      内田航、鎌形康司、アンディカ クリスティナ、冨田洋之、倉持麻奈、武中祐樹、萩原彰文、福尾誠、原田睦巳、和気秀文、内藤久士、青木茂樹
    • Organizer
      第46回日本磁気共鳴医学会大会
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2022-01-27  

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