| Project/Area Number |
18K09019
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 56020:Orthopedics-related
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
齋藤 琢 東京大学, 医学部附属病院, 准教授 (30456107)
酒井 崇匡 東京大学, 大学院工学系研究科(工学部), 教授 (70456151)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 腱 / 癒着 / ハイドロゲル / 腱癒着 |
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| Outline of Final Research Achievements |
Although tenorrhaphy is commonly conducted in ruptured tendon, postoperative complications, such as adhesion formation and tendon re-rupture, usually result in poor outcomes. In this study, we developed new anti-adhesive agent, using Oligo-Tetra-Peg gel which has four arm polyethylene glycol. The result showed that the hydrogel has an inhibitory effect on migration of scar tissues, and prevented adhesion formation around repaired tendons. In addition, the hydrogel didn't prevent healing process of tendon.
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| Academic Significance and Societal Importance of the Research Achievements |
腱断裂の治療では主に腱縫合術が行われる。しかしながら、腱縫合術後には少なからず周辺組織との癒着が起こり、術後の可動域制限により患者満足度の低下につながっている。そこで、本研究では東京大学工学部酒井研究室で開発されたハイドロゲル（Oligo-Tetra-Peg gel）を使用し、その癒着予防効果を検討した。その結果、癒着予防効果のみならず腱の修復過程も阻害しないことが明らかとなり、その学術的意義は大きい。今後はさらに臨床応用に向けた取り組みを進めていく。
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