| Project/Area Number |
18K09023
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 56020:Orthopedics-related
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| Research Institution | Gifu University |
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Principal Investigator |
Nozawa Satoshi 岐阜大学, 医学部附属病院, 講師 (20771679)
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| Co-Investigator(Kenkyū-buntansha) |
秋山 治彦 岐阜大学, 大学院医学系研究科, 教授 (60402830)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 低分子ヘパリン / drug delivery system |
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| Outline of Final Research Achievements |
We successfully made special low molecular weight heparin with some conjugation. The products were purified by molecular selective column.
A day after we applied the conjugates with FITC in P5 mice, it was delivered to the bone tissue specifically.
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| Academic Significance and Societal Importance of the Research Achievements |
我々の開発した化合物とBMPやFGFと併用することにより、従来骨癒合の遷延がみられた部位（脊椎固定術における椎間移植骨など）の骨癒合を促進させることが期待される。これにより、患者の外固定装着期間を短縮させられる可能性があり、社会的に有益な研究である。
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