Elucidation of the mechanism of osteoarthritis using kinematic analysis and the development of therapeutic devices

• Project/Area Number: 18K09054
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56020:Orthopedics-related
• Research Institution: The University of Tokyo
• Principal Investigator: Inui Hiroshi 東京大学, 医学部附属病院, 講師 (60583119)
• Co-Investigator(Kenkyū-buntansha): 小林 寛 東京大学, 医学部附属病院, 講師 (20407951) ; 冨田 哲也 大阪大学, 医学系研究科, 寄附講座准教授 (30283766) ; 武冨 修治 東京大学, 医学部附属病院, 講師 (70570018)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2018: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: キネマティクス / 変形性膝関節症 / 膝関節靱帯損傷 / 人工膝関節 / 変形性関節症 / 変形性関節症発生機序

Outline of Final Research Achievements

To elucidate the mechanism of osteoarthritis development, it is said that the mechanism of osteoarthritis development will be elucidated by creating a database of kinematics such as diseases that cause osteoarthritis, trauma, and treatment for osteoarthritis. We thought about the approach.
We have succeeded in creating a database of 3D dynamics analysis, and it is becoming clear what kind of dynamic changes will trigger osteoarthritis by using machine learning functions in the future. Furthermore, we have begun to develop a customized artificial joint that can reproduce the movement of each osteoarthritis patient before illness by using the kinematics prediction function calculated from the database.

Academic Significance and Societal Importance of the Research Achievements

変形性膝関節症を引き起こす動きが明らかになることで、今後、人工関節置換術や靱帯再建術の成績向上が期待できる。特に患者それぞれにより特化したカスタマイズ治療を充実させることが可能となる。
人工関節分野ではカスタマイズ型人工関節の開発は欧米を中心に始まっているが、対象は主に白色人種であり、白色人種の骨形態を基に作成されることがほとんどである。我々黄色人種と白色人種では骨形態やキネマティクスが異なることは周知の事実となり、我々黄色人種一人一人のためにカスタマイズされた人工関節の開発も将来性の高い意義深いものと考えられる。

Research Products

• [Journal Article] The higher patient-reported outcome measure group had smaller external rotation of the femur in bicruciate-stabilized total knee arthroplasty (2021)
  • Author(s): Kono Kenichi、Inui Hiroshi、Tomita Tetsuya、Yamazaki Takaharu、Taketomi Shuji、Yamagami Ryota、Kawaguchi Kohei、Tanaka Sakae
  • Journal Title: Knee Surgery, Sports Traumatology, Arthroscopy Volume: - Issue: 4 Pages: 1292-1299
  • DOI: 10.1007/s00167-021-06577-w
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] In vivo kinematics and cruciate ligament forces in bicruciate-retaining total knee arthroplasty (2021)
  • Author(s): Kono Kenichi、Inui Hiroshi、Tomita Tetsuya、Yamazaki Takaharu、Konda Shoji、Taketomi Shuji、Tanaka Sakae、D’Lima Darryl D.
  • Journal Title: Scientific Reports Volume: 11 Issue: 1 Pages: 5645-5645
  • DOI: 10.1038/s41598-021-84942-y
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] In vivo length change of ligaments of normal knees during dynamic high flexion (2020)
  • Author(s): Kono Kenichi、Konda Shoji、Yamazaki Takaharu、Tanaka Sakae、Sugamoto Kazuomi、Tomita Tetsuya
  • Journal Title: BMC Musculoskeletal Disorders Volume: 21 Issue: 1 Pages: 552-552
  • DOI: 10.1186/s12891-020-03560-3
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Weight-bearing status affects in vivo kinematics following mobile-bearing unicompartmental knee arthroplasty. (2020)
  • Author(s): Kono K, Inui H, Tomita T, Yamazaki T, Taketomi S, Yamagami R, Kawaguchi K, Sugamoto K, Tanaka S.
  • Journal Title: Knee Surgery, Sports Traumatology, Arthroscopy Volume: - Issue: 3 Pages: 718-724
  • DOI: 10.1007/s00167-020-05893-x
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] In vivo kinematic comparison before and after mobile-bearing unicompartmental knee arthroplasty during high-flexion activities (2020)
  • Author(s): Kono Kenichi、Inui Hiroshi、Tomita Tetsuya、Yamazaki Takaharu、Taketomi Shuji、Yamagami Ryota、Kawaguchi Kohei、Sugamoto Kazuomi、Tanaka Sakae
  • Journal Title: The Knee Volume: 27 Issue: 3 Pages: 878-883
  • DOI: 10.1016/j.knee.2020.03.002
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Comparison of finite helical axes of normal and anatomically designed prosthetic knees (2019)
  • Author(s): Konda Shoji、Tomita Tetsuya、Yamazaki Takaharu、Oda Kosaku、Nakajima Mikio、Nakane Kunio、Kono Kenichi、Fujito Toshitaka、Yoshikawa Hideki、Sugamoto Kazuomi
  • Journal Title: Clinical Biomechanics Volume: 65 Pages: 57-64
  • DOI: 10.1016/j.clinbiomech.2019.03.018
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Bicruciate-stabilised total knee arthroplasty provides good functional stability during high-flexion weight-bearing activities (2019)
  • Author(s): Kono, K. Inui, H. Tomita, T. Yamazaki, T. Taketomi, S. Sugamoto, K. Tanaka, S.
  • Journal Title: Knee Surgery, Sports Traumatology, Arthroscopy Volume: 27 Issue: 7 Pages: 2096-2103
  • DOI: 10.1007/s00167-019-05375-9
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] In Vivo Kinematics of Bicruciate-Retaining Total Knee Arthroplasty with Anatomical Articular Surface under High-Flexion Conditions (2019)
  • Author(s): Kono Kenichi、Inui Hiroshi、Tomita Tetsuya、Yamazaki Takaharu、Taketomi Shuji、Tanaka Sakae
  • Journal Title: The Journal of Knee Surgery Volume: - Issue: 04 Pages: 452-459
  • DOI: 10.1055/s-0039-1696959
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Bicruciate-retaining total knee arthroplasty reproduces in vivo kinematics of normal knees to a lower extent than unicompartmental knee arthroplasty. (2019)
  • Author(s): Kono K, Inui H, Tomita T, Yamazaki T, Taketomi S, Tanaka S.
  • Journal Title: Knee Surgery, Sports Traumatology, Arthroscopy Volume: - Issue: 9 Pages: 3007-3015
  • DOI: 10.1007/s00167-019-05754-2
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] In vivo three-dimensional kinematics of normal knees during different high-flexion activities. (2018)
  • Author(s): Kono K, Tomita T, Futai K, Yamazaki T, Tanaka S, Yoshikawa H, Sugamoto K
  • Journal Title: The Bone & Joint Journal Volume: 100-B（1） Issue: 1 Pages: 50-55
  • DOI: 10.1302/0301-620x.100b1.bjj-2017-0553.r2
  • Peer Reviewed / Open Access
• [Presentation] In Vivo Three-Dimensional Kinematics of Unicompartmental Knee Arthroplasty During Weight-Bearing and Non-Weight-Bearing High-Flexion Activities (2019)
  • Author(s): Kenichi Kono, Tetsuya Tomita, Hiroshi Inui, Takaharu Yamazaki, Tomofumi Kage, Teruya Ishibashi, Shoji Konda, Masashi Tamaki, Shuji Taketomi, Kazuomi Sugamoto, Sakae Tanaka, Darryl D’Lima
  • Organizer: International Scciety for Technology in Arthroplasty
  • Int'l Joint Research
• [Presentation] In vivo kinematic analysis of unicompartmental knee arthroplasty during high flexion activities (2018)
  • Author(s): Kenichi Kono, Tetsuya Tomita, Takaharu Yamazaki, Teruya Ishibashi, Toshitaka Fujito, Shoji Konda, Hiroshi Inui, Shuji Taketomi, Sakae Tanaka, Kazuomi Sugamoto
  • Organizer: 19th EFORT Congross 2018
  • Int'l Joint Research
• [Remarks] 東京大学医学部附属病院 整形外科
  • URL: http://www.u-tokyo-ortho.jp/