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Elucidation of the pharmacological action of the freezed-dried platlet-rich plasma and development of new bone -forming material

Research Project

Project/Area Number 18K09093
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 56020:Orthopedics-related
Research InstitutionChiba University

Principal Investigator

MASAHIKO SUZUKI  千葉大学, フロンティア医工学センター, 教授 (10312951)

Co-Investigator(Kenkyū-buntansha) 大鳥 精司  千葉大学, 大学院医学研究院, 教授 (40361430)
折田 純久  千葉大学, 大学院医学研究院, 特任准教授 (60638310)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords多血小板血漿 / 凍結乾燥 / 成長因子 / platelet rich plasma / Platelet Rich Plasma / platelet-rich plasma / pharmacological action / bone-forming material
Outline of Final Research Achievements

Phamacological activities of platelet rich plasma: PRP and freeze-dried: fd PRP were evaluated. ELIZA tests of PDGF, FGF, and EGF showed similar concentrations in fresh PRP and 52 weeks saved PRP. Lumbar posterolateral fusion models were allocated to the sham, autologous graft, artificial bone-alone, artificial bone+fdRPR, artificial bone+PRP. Histological examination revealed similar good results in artificial bone+fdPRP and artificial bone+PRP.

Academic Significance and Societal Importance of the Research Achievements

Platelet Rich Plasma: PRPと凍結乾燥したfreeze-dried:fd PRP(52週間保存後)の薬理活性はほぼ同程度だった。骨形成機能もBMPと同程度の効果があった。骨欠損のある患者で凍結乾燥したPRPが使用できれば臨床の現場で非常に有効である。今後は3-5年の長期保存の効果を明らかにするとともに、凍結乾燥PRPバンクの構築が実用化に向けて重要であると考える。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (8 results)

All 2020 2019 2018

All Journal Article (5 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 5 results,  Open Access: 2 results) Presentation (3 results)

  • [Journal Article] Freeze-Dried Platelet-Rich Plasma Induces Osteoblast Proliferation via Platelet-Derived Growth Factor Receptor-Mediated Signal Transduction2020

    • Author(s)
      Kinoshita H, Orita S, Inage K, Fujimoto K, Shiga Y, Abe K, Inoue M, Norimoto M, Umimura T, Ishii T, Yonemoto T, Kamoda H, Tsukanishi T, Akazawa T, Ohtori S
    • Journal Title

      Asian Spine J.

      Volume: 14(1) Issue: 1 Pages: 1-8

    • DOI

      10.31616/asj.2019.0048

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Freeze-Dried Platelet-Rich Plasma Induces Osteoblast Proliferation via Platelet-Derived Growth Factor Receptor-Mediated Signal Transduction.2020

    • Author(s)
      Kinoshita H, Orita S, Inage K, Fujimoto K, Shiga Y, Abe K, Inoue M, Norimoto M, Umimura T, Ishii T, Yonemoto T, Kamoda H, Tsukanishi T, Suzuki M, Hirosawa N, Akazawa T, Ohtori S.
    • Journal Title

      Asian Spine J.

      Volume: Jan 14(1) Pages: 1-8

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Skeletal Muscle Cell Oxidative Stress as a Possible Therapeutic Target in a Denervation-Induced Experimental Sarcopenic Model2019

    • Author(s)
      Kinoshita H, Orita S, Inage K, Yamauchi K, Abe K, Inoue M, Norimoto M, Umimura T, Eguchi Y, Fujimoto K, Shiga Y, Kanamoto H, Aoki Y, Furuya T, Suzuki M, Akazawa T, Takahashi K, Ohtori S.
    • Journal Title

      Spine

      Volume: 44 Issue: 8 Pages: 446-455

    • DOI

      10.1097/brs.0000000000002891

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] A comparative study of flat surface design and medial pivot design in posterior cruciate-retaining total knee arthroplasty: a matched pair cohort study of two years.2018

    • Author(s)
      Nakamura J, Inoue T, Suguro T, Suzuki M, Sasho T, Hagiwara S, Akagi R, Orita S, Inage K, Akazawa T, Ohtori S
    • Journal Title

      BMC Musculoskelet Disord.

      Volume: 19 Pages: 234-241

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Changes in proinflammatory cytokines, neuropeptides, and microglia in an animal model of monosodium iodoacetate-induced hip osteoarthritis2018

    • Author(s)
      Kawarai Yuya、Orita Sumihisa、Nakamura Junichi、Miyamoto Shuichi、Suzuki Miyako、Inage Kazuhide、Hagiwara Shigeo、Suzuki Takane、Nakajima Takayuki、Akazawa Tsutomu、Ohtori Seiji
    • Journal Title

      Journal of Orthopaedic Research

      Volume: 36 Issue: 11 Pages: 2978-2986

    • DOI

      10.1002/jor.24065

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Future Knee人工関節の動態解析2019

    • Author(s)
      鈴木昌彦、中村順一、萩原茂雄、井上貴之、山本慶太郎、勝呂徹、大鳥精司
    • Organizer
      第49回日本人工関節学会
    • Related Report
      2018 Research-status Report
  • [Presentation] OLIF手術における分節動脈損傷回避を担保するための画像的および解剖学的考察2018

    • Author(s)
      折田純久 稲毛一秀 志賀康浩 阿部幸喜 井上雅寛 木下英福 乗本将暉 海村朋孝 古矢丈雄 牧聡 大鳥精司
    • Organizer
      第91回日本整形外科学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 多血小板血漿の腰椎後方椎体間固定術後の骨癒合に関する前向き研究2018

    • Author(s)
      大鳥精司 久保田剛 志賀康浩 鴨田博人 山下正臣 折田純久 稲毛一秀 牧聡 古矢丈雄
    • Organizer
      第91回日本整形外科学会
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2022-01-27  

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