• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Can synovial fluid-derived mesenchymal cells substitute for synovium-derived cells?

Research Project

Project/Area Number 18K09097
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 56020:Orthopedics-related
Research InstitutionTokyo Medical and Dental University

Principal Investigator

Jinno Tetsuya  東京医科歯科大学, 医学部附属病院, 非常勤講師 (90343152)

Co-Investigator(Kenkyū-buntansha) 宮武 和正  東京医科歯科大学, 大学院医歯学総合研究科, 助教 (00777435)
辻 邦和  東京医科歯科大学, 大学院医歯学総合研究科, 寄附講座准教授 (20323694)
古賀 英之  東京医科歯科大学, 大学院医歯学総合研究科, 教授 (30594080)
片桐 洋樹  東京医科歯科大学, 大学院医歯学総合研究科, 非常勤講師 (50795028)
宗田 大  東京医科歯科大学, 大学院医歯学総合研究科, 非常勤講師 (50190864)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords関節液由来間葉系幹細胞 / 滑膜由来間葉系幹細胞 / 再生医療 / 滑膜幹細胞 / 関節液 / 再生治療
Outline of Final Research Achievements

The purpose of this study is to investigate the proliferative potential and pluripotency of synovial fluid-derived stem cells (confirmation of non-inferiority with synovium-derived stem cells), both in vitro and in vivo.
We found that synovial fluid-derived stem cells had the same pluripotency as synovium-derived stem cells, although they showed lower colony forming ability and cell proliferation compared with synovium-derived stem cells. Interestingly, there was no significant difference between the two groups when the same number of cells were transplanted to cartilage defect of rats.

Academic Significance and Societal Importance of the Research Achievements

簡便に採取できる関節液由来の間葉系幹細胞が、従来の関節鏡で採取していた滑膜由来幹細胞と比較して軟骨再生においては非劣性であることが分かった。つまり、より患者さんに負担の少ない方法であっても、同等の治療効果が得られることがわかった。今回の結果は今後の再生医療の発展にもつながると考えられる。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (21 results)

All 2021 2020 2019 2018

All Journal Article (14 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 11 results,  Open Access: 1 results) Presentation (7 results) (of which Int'l Joint Research: 7 results)

  • [Journal Article] Does surgical body position influence the risk for neurovascular injury in total hip arthroplasty? A magnetic resonance imaging study2021

    • Author(s)
      Takada Ryohei、Jinno Tetsuya、Miyatake Kazumasa、Hirao Masanobu、Yoshii Toshitaka、Kawabata Shigenori、Okawa Atsushi
    • Journal Title

      Orthopaedics & Traumatology: Surgery & Research

      Volume: Epub Issue: 8 Pages: 102817-102817

    • DOI

      10.1016/j.otsr.2021.102817

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Incidence of tensor fascia lata muscle atrophy after using the modified Watson-Jones anterolateral approach in total hip arthroplasty2020

    • Author(s)
      Takada Ryohei、Jinno Tetsuya、Miyatake Kazumasa、Hirao Masanobu、Yoshii Toshitaka、Okawa Atsushi
    • Journal Title

      European Journal of Orthopaedic Surgery & Traumatology

      Volume: 31 Issue: 3 Pages: 533-540

    • DOI

      10.1007/s00590-020-02806-z

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association between Hemiarthroplasty vs. Total Hip Arthroplasty and Major Surgical Complications among Patients with Femoral Neck Fracture2020

    • Author(s)
      Ogawa Takahisa、Yoshii Toshitaka、Moriwaki Mutsuko、Morishita Shingo、Oh Yoto、Miyatake Kazumasa、Nazarian Ara、Shiba Koichiro、Okawa Atsushi、Fushimi Kiyohide、Fujiwara Takeo
    • Journal Title

      Journal of Clinical Medicine

      Volume: 9 Issue: 10 Pages: 3203-3203

    • DOI

      10.3390/jcm9103203

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intra-articular Injection of Pure Platelet-Rich Plasma Is the Most Effective Treatment for Joint Pain by Modulating Synovial Inflammation and Calcitonin Gene-Related Peptide Expression in a Rat Arthritis Model2020

    • Author(s)
      Araya Naoko、Miyatake Kazumasa、Tsuji Kunikazu、Katagiri Hiroki、Nakagawa Yusuke、Hoshino Takashi、Onuma Hiroaki、An Saisei、Nishio Hirofumi、Saita Yoshitomo、Sekiya Ichiro、Koga Hideyuki
    • Journal Title

      The American Journal of Sports Medicine

      Volume: 48 Issue: 8 Pages: 2004-2012

    • DOI

      10.1177/0363546520924011

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of 5-year postoperative results between standard-length stems and short stems in one-stage bilateral total hip arthroplasty: a randomized controlled trial2020

    • Author(s)
      Hirao Masanobu、Miyatake Kazumasa、Koga Daisuke、Takada Ryohei、Koyano Gaku、Okawa Atsushi、Jinno Tetsuya
    • Journal Title

      European Journal of Orthopaedic Surgery & Traumatology

      Volume: 31 Issue: 4 Pages: 743-753

    • DOI

      10.1007/s00590-020-02828-7

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fibrotic changes in the infrapatellar fat pad induce new vessel formation and sensory nerve fiber endings that associate prolonged pain.2020

    • Author(s)
      Onuma H, Tsuji K, Hoshino T, Inomata K, Udo M, Nakagawa Y, Katagiri H, Miyatake K, Watanabe T, Sekiya I, Muneta T, Koga H
    • Journal Title

      J Orthop Res.

      Volume: In press Issue: 6 Pages: 1296-1306

    • DOI

      10.1002/jor.24580

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synovial fluid-derived mesenchymal cells have non-inferior chondrogenic potential and can be utilized for regenerative therapy as substitute for synovium-derived cells.2020

    • Author(s)
      Amemiya M, Tsuji K, Katagiri H, Miyatake K, Nakagawa Y, Sekiya I, Muneta T, Koga H.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 523 Issue: 2 Pages: 465-472

    • DOI

      10.1016/j.bbrc.2019.12.068

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Portable imageless navigation system and surgeon’s estimate for accurate evaluation of acetabular cup orientation during total hip arthroplasty in supine position2020

    • Author(s)
      Takada Ryohei、Jinno Tetsuya、Miyatake Kazumasa、Hirao Masanobu、Yoshii Toshitaka、Okawa Atsushi
    • Journal Title

      European Journal of Orthopaedic Surgery & Traumatology

      Volume: 30 Issue: 4 Pages: 707-712

    • DOI

      10.1007/s00590-020-02625-2

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparative study of stem anteversion using a cementless tapered wedge stem in dysplastic hips between the posterolateral and anterolateral approaches2019

    • Author(s)
      Taniguchi Naofumi、Jinno Tetsuya、Koga Daisuke、Ochiai Satoshi、Okawa Atsushi、Haro Hirotaka
    • Journal Title

      Orthopaedics & Traumatology: Surgery & Research

      Volume: 105 Issue: 7 Pages: 1271-1276

    • DOI

      10.1016/j.otsr.2019.08.006

    • Related Report
      2019 Research-status Report
  • [Journal Article] Portable imageless navigation system and surgeon's estimate for accurate evaluation of acetabular cup orientation during total hip arthroplasty in supine position.2019

    • Author(s)
      Takada R, Jinno T, Miyatake K, Hirao M, Yoshii T, Okawa A.
    • Journal Title

      European Journal of Orthopaedic Surgery & Traumatology

      Volume: Epub

    • Related Report
      2019 Research-status Report
  • [Journal Article] Effect of exercise therapy combined with branched-chain amino acid supplementation on muscle strength in elderly women after total hip arthroplasty: a randomized controlled trial.2019

    • Author(s)
      Ikeda T, Matsunaga Y, Kanbara M5, Kamono A, Masuda T, Watanabe M, Nakanishi R, Jinno T,.
    • Journal Title

      Asia Pac J Clin Nutr.

      Volume: 28 Pages: 720-26

    • Related Report
      2019 Research-status Report
  • [Journal Article] Direct anterior versus anterolateral approach in one-stage supine total hip arthroplasty. Focused on nerve injury: A prospective, randomized, controlled trial2018

    • Author(s)
      Takada Ryohei、Jinno Tetsuya、Miyatake Kazumasa、Hirao Masanobu、Kimura Akimasa、Koga Daisuke、Yagishita Kazuyoshi、Okawa Atsushi
    • Journal Title

      Journal of Orthopaedic Science

      Volume: 23 Issue: 5 Pages: 783-787

    • DOI

      10.1016/j.jos.2018.05.005

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Longitudinal morphological change of acetabular subchondral bone cyst after total hip arthroplasty in developmental dysplasia of the hip2018

    • Author(s)
      Takada Ryohei、Jinno Tetsuya、Miyatake Kazumasa、Yamauchi Yuki、Koga Daisuke、Yagishita Kazuyoshi、Okawa Atsushi
    • Journal Title

      European Journal of Orthopaedic Surgery & Traumatology

      Volume: 28 Issue: 4 Pages: 621-625

    • DOI

      10.1007/s00590-017-2115-5

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Persistent synovial inflammation plays important roles in persistent pain development in the rat knee before cartilage degradation reaches the subchondral bone.2018

    • Author(s)
      Hoshino T, Tsuji K, Onuma H, Udo M, Ueki H, Akiyama M, Abula K, Katagiri H, Miyatake K, Watanabe T, Sekiya I, Koga H, Muneta T.
    • Journal Title

      BMC Musculoskelet Disord.

      Volume: 19 Issue: 1 Pages: 291-291

    • DOI

      10.1186/s12891-018-2221-5

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Evaluation of articular cartilage repair ability using synovial fluid derived mesenchymal stem cells.2018

    • Author(s)
      Masaki Amemiya, Kunikazu Tsuji, Ichiro Sekiya, Takeshi Muneta, Hideyuki Koga.
    • Organizer
      Orthopaedic Research Society 2018 Annual Meeting
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] IL1b enhances proliferation of synovial mesenchymal stem cells independent from its cell surface receptor, CD121a.2018

    • Author(s)
      Etsuko Matsumura, Kunikazu Tsuji, Hideyuki Koga, Ichiro Sekiya, Takeshi Muneta.
    • Organizer
      Orthopaedic Research Society 2018 Annual Meeting
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Evaluation Of Pain Behavioral And Joint Change Of Rat Arthritis Model Induced By Low And High Dose Monoiodoacetic Acid.2018

    • Author(s)
      Takashi Hoshino, Kunikazu Tsuji, Hiroaki Onuma, Ichiro Sekiya, Takeshi Muneta, Hideyuki Koga.
    • Organizer
      Orthopaedic Research Society 2018 Annual Meeting
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Inflammatory cell dynamics and pain behavior during acute inflammation in rat knee joint.2018

    • Author(s)
      Kei Inomata, Kunikazu Tsuji, Ichiro Sekiya, Takeshi Muneta, Hideyuki Koga.
    • Organizer
      Orthopaedic Research Society 2018 Annual Meeting
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Intra-articular Injection of Synovial Mesenchymal Stem Cells in the Anterior Cruciate Ligament Transection Model in Rats :Evaluation of Cell-number Difference on Prevention of Cartilage Damage and Lower Limb Pain .2018

    • Author(s)
      Hiroko Ueki, Hiroki Katagiri, Kunikazu Tsuji, Kazumasa Miyatake, Takashi Hoshino, Hiroaki Onuma, Masaki Amemiya, Ichiro Sekiya, Hideyuki Koga, Takeshi Muneta.
    • Organizer
      Orthopaedic Research Society 2018 Annual Meeting
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Leg pain behavior correlates fibrosis and angiogenesis of the infrapatellar fat pad induced by monoiodoacetic acid.2018

    • Author(s)
      Hiroaki Onuma, Kunikazu Tsuji, Takashi Hoshino, Ichiro Sekiya, Takeshi Muneta, Hideyuki Koga.
    • Organizer
      OARSI 2018 World Congress on Osteoarthritis
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Acute inflammatory response is prerequisit to initiate proper healing process during meniscal regeneration in mice.2018

    • Author(s)
      Miyoko Ojima, Kanehiro Hiyama, Kazumasa Miyatake, Hiroki Katagiri, Takeshi Muneta, Ichiro Sekiya, Hideyuki Koga, Kunikazu Tsuji.
    • Organizer
      OARSI 2018 World Congress on Osteoarthritis
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research

URL: 

Published: 2018-04-23   Modified: 2022-01-27  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi