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Bone-to-muscle network mediated by HGF/c-Met signaling in osteoporosis

Research Project

Project/Area Number 18K09116
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 56020:Orthopedics-related
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

Tonomura Hitoshi  京都府立医科大学, 医学(系)研究科(研究院), 助教 (70604304)

Co-Investigator(Kenkyū-buntansha) 高取 良太  京都府立医科大学, 医学(系)研究科(研究院), 講師 (10351355)
長江 将輝  京都府立医科大学, 医学(系)研究科(研究院), 講師 (60604303)
Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
KeywordsHGF / 椎間板 / 骨粗鬆症 / サルコペニア / HIF-1α / 椎体形成術 / PRP
Outline of Final Research Achievements

We showed that hypoxia-inducible factors play an important role in the mechanism by which HGF/c-Met signaling promotes cell proliferation of intervertebral disc cells. In addition, the expression patterns of HGF/c-Met related signaling, in vertebrae, intervertebral discs, and paraspinal muscles in a rat osteoporotic vertebral bone defect model were also clarified. We demonstrated the possible involvement of HGF/c-Met signaling in the interorgan network of bone, intervertebral disc, and muscle in spinal degenerative diseases.

Academic Significance and Societal Importance of the Research Achievements

超高齢化社会において脊椎変性疾患は増加の一途をたどり、高齢者の健康寿命を低下させる原因となっている。脊椎の加齢性変化の中で、骨強度の低下、椎間板変性および傍脊柱筋の筋肉量と筋肉機能低下が生じ、それぞれの相互作用があると考えるがその病態は明らかにされていない。本研究成果は高齢者の骨、椎間板および筋肉の老化が共存した運動器疾患に対して有用な予防・治療法の開発につながると考える。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (3 results)

All 2021 2020

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (1 results)

  • [Journal Article] Hepatocyte growth factor regulates HIF-1α-induced nucleus pulposus cell proliferation through MAPK-, PI3K/Akt-, and STAT3-mediated signaling2020

    • Author(s)
      Itsuji T、Tonomura H、Ishibashi H、Mikami Y、Nagae M、Takatori R、Tanida T、Matsuda KI、Tanaka M、Kubo T
    • Journal Title

      Journal of Orthopaedic Research

      Volume: - Issue: 6 Pages: 1184-1191

    • DOI

      10.1002/jor.24679

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Potential Role of Hepatocyte Growth Factor in Degenerative Disorders of the Synovial Joint and Spine2020

    • Author(s)
      Tonomura Hitoshi、Nagae Masateru、Takatori Ryota、Ishibashi Hidenobu、Itsuji Tomonori、Takahashi Kenji
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 21 Issue: 22 Pages: 8717-8717

    • DOI

      10.3390/ijms21228717

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 肝細胞増殖因子が髄核細胞のHIF-1α発現と細胞増殖に与える影響2021

    • Author(s)
      井辻智典,外村 仁,長江将輝,高取良太,清水佑一,石橋秀信,谷田任司,松田賢一,田中雅樹,高橋謙治
    • Organizer
      第36回日本整形外科学会基礎学術集会
    • Related Report
      2021 Annual Research Report

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Published: 2018-04-23   Modified: 2023-01-30  

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