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Potential for IL-18 immunotherapy targeting tumor-associated macrophages

Research Project

Project/Area Number 18K09124
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 56020:Orthopedics-related
Research InstitutionHyogo Medical University

Principal Investigator

Yamada Naoko  兵庫医科大学, 医学部, 講師 (10319858)

Co-Investigator(Kenkyū-buntansha) 中正 恵二  兵庫医科大学, 医学部, 教授 (00217712)
山根木 康嗣  兵庫医科大学, 医学部, 講師 (00434944)
西浦 弘志  兵庫医科大学, 医学部, 助教 (90284760)
Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
KeywordsIL-18 / 腫瘍関連マクロファージ / がん微小環境 / M1 / M2 / M1マクロファージ / M2マクロファージ / インターロイキン18
Outline of Final Research Achievements

Interleukin 18 (IL-18) was discovered in our college, and its physiological significance was investigated by researchers around the world. It was shown that IL-18 plays an important role in biological functions such as the maintenance of homeostasis. Our studies have shown that IL-18 has anti-tumor activity against cancer. The activity is mainly mediated by T cells and NK cells. In this study, we investigate the effect of IL-18 on macrophages, especially on tumor-associated macrophages. We established a system to induce differentiation of M1 and M2 macrophages for in vitro analysis and examined the characteristics of M1 and M2 under different culture conditions. We found that IL-18 has a suppressive effect on the expression of various M2 markers although IL-18 did not affect the induction of M1 and M2 differentiation.

Academic Significance and Societal Importance of the Research Achievements

我々はIL-18の抗腫瘍効果に関する研究を行ってきた。これまでにT細胞、NK細胞を介する以外の作用で抗腫瘍効果を発揮することが分かっているが、そのメカニズムは分かっていない。腫瘍内には腫瘍関連マクロファージ(TAM)が存在し、M2タイプのTAMが腫瘍促進性に働くことが分かっている。本研究ではIL-18は直接M1, M2の分化誘導には影響していなかったが、M2に作用し抑制していることが明らかとなった。このことによりIL-18の新たな生理的意義が明らかにされ、新たな視点によるがん治療法の開発に貢献できると考える。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (2 results)

All 2019 2018

All Presentation (2 results)

  • [Presentation] IL-18誘導ケモカインによるがん転移抑制機構の解明2019

    • Author(s)
      山田 直子、平山 円、寺田 信行
    • Organizer
      日本分子生物学会
    • Related Report
      2019 Research-status Report
  • [Presentation] マウス骨肉腫に対するIL-18誘導性がん転移抑制シグナル2018

    • Author(s)
      山田 直子、平山 円、山根木 康嗣、西浦 弘志、藤原 勇輝、中正 恵二、寺田 信行
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2023-01-30  

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