| Project/Area Number |
18K09141
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 56030:Urology-related
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| Research Institution | Kinjo Gakuin University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
松崎 俊博 琉球大学, 医学(系)研究科(研究院), 助教 (50244330)
筒井 正人 琉球大学, 医学(系)研究科(研究院), 教授 (70309962)
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| Project Period (FY) |
2018-04-01 – 2024-03-31
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| Project Status |
Completed (Fiscal Year 2023)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | テストステロン補充 / 一酸化窒素 / 虚血性心疾患 / テストステロン / NOx / 硝酸塩 / 硝酸ナトリウム / 虚血性心血管疾患 |
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| Outline of Final Research Achievements |
We have generated mice with reduced levels of endogenous or exogenous NO production and developed models that prone to myocardial infarction. In these mice, the normal testosterone level group (testosterone replacement model) showed decreased survival rates and worsening coronary risk factors compared to the low testosterone level group. When NO levels were reduced in vivo, testosterone contributed to the development of atherosclerosis, induction of chronic inflammation, and exacerbation of myocardial infarction. However, it was suggested that these exacerbating effects could be suppressed by normalizing NO levels through oral administration of nitrates.
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| Academic Significance and Societal Importance of the Research Achievements |
加齢男性・性腺機能低下（late-onset hypogonadism: LOH）症候群の治療として、テストステロン補充療法が行われているが、近年、テストステロン補充による心血管疾患の増悪作用に関する報告が相次いでいる。本研究は、テストステロン補充が有害作用を呈する機序に、生体内のNO産生低下が関与し、硝酸塩の投与により生体内のNOレベルを増加させることで、有害作用の発現を抑制しうる可能性を示した。本研究で得られた知見は、より安全にテストステロン補充療法を行うための新たな治療法の開発に、貢献を果たすことが期待される。
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