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Development of artifact-less and treatment decision maker focusing on prostate cancer men undergoing active surveillance therapy

Research Project

Project/Area Number 18K09145
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 56030:Urology-related
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

Okihara Koji  京都府立医科大学, 医学(系)研究科(研究院), 准教授 (80285270)

Co-Investigator(Kenkyū-buntansha) 浮村 理  京都府立医科大学, 医学(系)研究科(研究院), 教授 (70275220)
白石 匠  京都府立医科大学, 医学(系)研究科(研究院), 助教 (70405314)
本郷 文弥  京都府立医科大学, 医学(系)研究科(研究院), 准教授 (80291798)
上田 紗弥 (伊藤紗弥)  京都府立医科大学, 医学(系)研究科(研究院), 研究員 (90534511)
藤原 敦子  京都府立医科大学, 医学(系)研究科(研究院), 講師 (20457980)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2019: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2018: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywords前立腺癌 / 監視療法 / 局所療法 / マーカー / アーチファクト / 穿刺針 / MRI / 超音波
Outline of Final Research Achievements

The key to determining the guideline for the continuation of monitoring of prostate cancer surveillance patients or the transition to curative treatment is the progression of prostate cancer lesions diagnosed by needle biopsy at the time of decision on surveillance therapy. We have developed an imaging artifact-less maker that can recognize the three-dimensional position inside the prostate. A non-clinical experiment of the developed marker was conducted for the purpose of clinical application of this marker to humans. Specifically, we conducted animal experiments using phantoms and dogs, and conducted image comparison tests with the market metal marker using multiparametric MRI and transrectal ultrasonic tomography, demonstrating the superiority of the development marker. For the purpose of clinical use (manufacturing) in surveillance therapy, PMDA provided face-to-face advice and established the outline of non-clinical studies required in the future.

Academic Significance and Societal Importance of the Research Achievements

前立腺癌診断に頻用されるMRI・超音波・CT全てでアーチファクトレスなマーカは本開発品のみであり、日本発のシーズに基づく本マーカの製品化が、世界的な前立腺癌の治療の変革に不可欠なツールとなる。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (21 results)

All 2020 2019 2018

All Journal Article (10 results) (of which Peer Reviewed: 10 results,  Open Access: 10 results) Presentation (6 results) (of which Int'l Joint Research: 2 results,  Invited: 5 results) Book (3 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 1 results)

  • [Journal Article] Magnetic resonance imaging/transrectal ultrasound fusion‐targeted prostate biopsy using three‐dimensional ultrasound‐based organ‐tracking technology: Initial experience in Japan2019

    • Author(s)
      Yamada Yasuhiro、Fujihara Atsuko、Shiraishi Takumi、Ueda Takashi、Yamada Takeshi、Ueno Akihisa、Inoue Yuta、Kaneko Masatomo、Kamoi Kazumi、Hongo Fumiya、Okihara Koji、Ukimura Osamu
    • Journal Title

      International Journal of Urology

      Volume: 26 Issue: 5 Pages: 544-549

    • DOI

      10.1111/iju.13924

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of androgen deprivation therapy on other-cause of mortality in elderly patients with clinically localized prostate cancer treated with modern radiotherapy: Is there a negative impact?2019

    • Author(s)
      Yamazaki H, Masui K, Suzuki G, Nakamura S, Aibe N, Shimizu D, Yamada K, Okihara K, Shiraishi T, Kotsuma T, Yoshida K, Tanaka E, Otani K, Yoshioka Y, Ogawa K, Nishikawa T, Okabe H.
    • Journal Title

      J Clin Med

      Volume: 8 Issue: 3 Pages: 338-338

    • DOI

      10.3390/jcm8030338

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prostate cancer meeting the Japanese active surveillance criteria and diagnosed by community-based prostate-specific antigen screening: A 21-year follow-up study.2019

    • Author(s)
      Hongo F, Okihara K, Kitamura K, Fujihara A, Yamada Y, Shiraishi T, Konishi E, Ukimura O.
    • Journal Title

      Int J Urol.

      Volume: 26 Issue: 8 Pages: 827-832

    • DOI

      10.1111/iju.14037

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Less nephrotoxicity of paclitaxel and ifosfamide plus nedaplatin for refractory or relapsed germ cell tumors in patients with impaired renal function.2019

    • Author(s)
      Shiraishi T, Nakamura T, Takamura T, Oishi M, Yamada T, Yamada Y, Ueda T, Fujihara A, Hongo F, Okihara K, Ukimura O.
    • Journal Title

      Int J Urol.

      Volume: 27 Issue: 2 Pages: 134-139

    • DOI

      10.1111/iju.14147

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prostate cancer diagnosis and treatment using multiparametric transrectal ultrasonography.2019

    • Author(s)
      Okihara K.
    • Journal Title

      J Med Ultrasonics.

      Volume: 43 Issue: 4 Pages: 363-366

    • DOI

      10.1007/s10396-019-00963-1

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Editorial Comment to Impact of age on quality of life in patients with localized prostate cancer treated with high-dose rate brachytherapy combined with external beam radiotherapy.2018

    • Author(s)
      Okihara K.
    • Journal Title

      Int J Urol.

      Volume: 25 Issue: 4 Pages: 371-372

    • DOI

      10.1111/iju.13570

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] CNPY2 inhibits MYLIP-mediated AR protein degradation in prostate cancer cells.2018

    • Author(s)
      Ito S, Ueno A, Ueda T, Nakagawa H, Taniguchi H, Kayukawa N, Fujihara-Iwata A, Hongo F, Okihara K, Ukimura O
    • Journal Title

      Oncotarget.

      Volume: 9 Issue: 25 Pages: 17645-17655

    • DOI

      10.18632/oncotarget.24824

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Therapy-related acute myeloid leukemia and myelodysplastic syndrome among refractory germ cell tumor patients.2018

    • Author(s)
      Inoue Y, Nakamura T, Nakanishi H, Oishi M, Hongo F, Okihara K, Mizutani S, Kuroda J, Ukimura O.
    • Journal Title

      Int J Urol.

      Volume: 25 Issue: 7 Pages: 678-683

    • DOI

      10.1111/iju.13597

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nationwide Japanese Prostate Cancer Outcome Study of Permanent Iodine-125 Seed Implantation (J-POPS): first analysis on survival2018

    • Author(s)
      Ito H, Wang D, Zha X, Inamura S, Seki M, Taga M, Yokoyama O.
    • Journal Title

      Life Sci.

      Volume: 23 Issue: 6 Pages: 1148

    • DOI

      10.1007/s10147-018-1309-0

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparison of Image-Guided Intensity-Modulated Radiotherapy and Low-dose Rate Brachytherapy with or without External Beam Radiotherapy in Patients with Localized Prostate Cancer.2018

    • Author(s)
      Tsubokura T, Yamazaki H, Masui K, Sasaki N, Shimizu D, Suzuki G, Nakamura S, Yamada K, Okihara K, Shiraishi T, Yoshida K, Nishikawa T, Okabe H.
    • Journal Title

      Sci Rep.

      Volume: 12 Issue: 1 Pages: 10538-10538

    • DOI

      10.1038/s41598-018-28730-1

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Analysis of the big data of serum PSA value by age in medical examination for Japanese population。. American Urological Association Annual meeting.2019

    • Author(s)
      Mineyuki Kato 1),Koji Okihara 1),Yoshinori Marunaka 2) and Osamu Ukimura 1)
    • Organizer
      American Urological Association Annual meeting.
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 血清PSA値の新たなコンセプトの導入と、新規腫瘍マーカー診療応用の障壁2019

    • Author(s)
      沖原宏治
    • Organizer
      第107回日本泌尿器科学会総会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] A 21-year follow-up study of prostate cancer cases diagnosed by community-based PSA screening that met the Japanese Active Surveillance criteria2018

    • Author(s)
      Koji Okihara
    • Organizer
      JUA/UAA annual meeting
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] シンポジウム27 前立腺癌薬物療法の過去、現在、未来2018

    • Author(s)
      沖原宏治
    • Organizer
      第106回日本泌尿器科学会総会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 領域横断42018

    • Author(s)
      沖原宏治
    • Organizer
      第91回日本超音波医学会学術集会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 前立腺癌治療と性機能障害2018

    • Author(s)
      沖原宏治
    • Organizer
      日本性機能学会中部総会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Book] 前立腺がん検診ガイドライン 2018年度版 (日本泌尿器科学会編)第5章2018

    • Author(s)
      沖原 宏冶
    • Publisher
      Medical View社
    • Related Report
      2018 Research-status Report
  • [Book] 外来での疾患別プライマリーエコー「前立腺腫大」2018

    • Author(s)
      沖原宏冶
    • Publisher
      文光堂
    • Related Report
      2018 Research-status Report
  • [Book] ロボット支援手術「ナビゲーションによるRARP」2018

    • Author(s)
      本田俊一朗 沖原宏冶 浮村 理
    • Publisher
      Medical View社
    • Related Report
      2018 Research-status Report
  • [Patent(Industrial Property Rights)] 医療用イメージガイダンスマーカー2020

    • Inventor(s)
      浮村 理 沖原宏治
    • Industrial Property Rights Holder
      京都府公立大学法人
    • Industrial Property Rights Type
      特許
    • Filing Date
      2020
    • Acquisition Date
      2020
    • Related Report
      2020 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 医療用イメージガイダンスマーカー2019

    • Inventor(s)
      沖原宏治 浮村 理
    • Industrial Property Rights Holder
      沖原宏治 浮村 理
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Related Report
      2019 Research-status Report

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Published: 2018-04-23   Modified: 2022-01-27  

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