| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Clinical research of patients with urolithiasis revealed that dyslipidemia (LDL/HDL ratio) was associated with the severity of urolithiasis, patients with urolithiasis had higher prevalence of non-alcoholic fatty liver disease (NAFLD), and NAFLD was also associated with urinary abnormalities such as hyperoxaluria. In addition, basic research using renal epithelial culture model of lipotoxicity revealed that lipid accumulation increased oxalate-induced cellular injury and calcium oxalate crystal adhesion.
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