Whole genome sequence analysis of ADPKD

• Project/Area Number: 18K09151
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56030:Urology-related
• Research Institution: Juntendo University
• Principal Investigator: Horie Shigeo 順天堂大学, 医学(系)研究科(研究院), 教授 (40190243)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 多発性嚢胞腎 / ADPKD / PKD1 / PKD2 / 生殖細胞系列 / 常染色体優性多発性嚢胞腎 / 生殖細胞系列変異 / 遺伝子解析 / 次世代シークエンサー / 全ゲノムシークエンシング / WGS

Outline of Final Research Achievements

Analysis of germline mutations and its association with clinical severity was examined in patients with ADPKD. DNA analysis of 258 patients with ADPKD was completed. PKD1 mutations were identified in 186 cases, while PKD2 mutations were detected in 69 cases (26.7%).

Academic Significance and Societal Importance of the Research Achievements

同一家系内での解析は20家系計44名であり、家系内の遺伝子変異部位は一致した。親もしくは同胞の年長者（A）の腎機能と、子もしくは同胞の年少者（B）がAの年齢に達した時の予測腎機能（Mayo分類より算出）を比較したところ、Aの実測eGFR値とBの予測eGFR値の差が15mL/min/1.73m 2 以下であったのは、11家系（55％）であった。同一家系内の遺伝子解析にMayo分類を組み合わせると腎予後予測に有用な可能性が示唆された。

Research Products

• [Journal Article] Factors predicting decline in renal function and kidney volume growth in autosomal dominant polycystic kidney disease: a prospective cohort study (Japanese Polycystic Kidney Disease registry: J-PKD) (2021)
  • Author(s): Uchiyama K, Mochizuki T, Shimada Y, Nishio S, Kataoka H, Mitobe M, Tsuchiya K, Hanaoka K, Ubara Y, Suwabe T, Sekine A, Nutahara K, Tsuruya K, Ishimura E, Nakatani S, Sofue T, Tanaka S, Narita I, Maruyama S, Horie S, Muto S.
  • Journal Title: Clin Exp Nephrol Volume: 25 Issue: 9 Pages: 970-980
  • DOI: 10.1007/s10157-021-02068-x
  • Peer Reviewed / Open Access
• [Journal Article] Preservation of kidney function irrelevant of total kidney volume growth rate with tolvaptan treatment in patients with autosomal dominant polycystic kidney disease (2021)
  • Author(s): Horie Shigeo、Muto Satoru、Kawano Haruna、Okada Tadashi、Shibasaki Yoshiyuki、Nakajima Koji、Ibuki Tatsuki
  • Journal Title: Clinical and Experimental Nephrology Volume: 25 Issue: 5 Pages: 467-478
  • DOI: 10.1007/s10157-020-02009-0
  • Peer Reviewed / Open Access
• [Journal Article] Imaging Identification of Rapidly Progressing Autosomal Dominant Polycystic Kidney Disease: Simple Eligibility Criterion for Tolvaptan (2020)
  • Author(s): Higashihara Eiji、Horie Shigeo、Muto Satoru、Kawano Haruna、Tambo Mitsuhiro、Yamaguchi Tsuyoshi、Taguchi Satoru、Kaname Shinya、Yokoyama Kenich、Yoshioka Tatsuya、Furukawa Toshihito、Fukuhara Hiroshi
  • Journal Title: American Journal of Nephrology Volume: 51 Issue: 11 Pages: 881-890
  • DOI: 10.1159/000511797
  • Peer Reviewed / Open Access
• [Journal Article] Estimation of Changes in Kidney Volume Growth Rate in ADPKD (2020)
  • Author(s): Higashihara Eiji、Fukuhara Hiroshi、Ouyang John、Lee Jennifer、Nutahara Kikuo、Tanbo Mistuhiro、Yamaguchi Tsuyoshi、Taguchi Satoru、Muto Satoru、Kaname Shinya、Miyazaki Isao、Horie Shigeo
  • Journal Title: Kidney International Reports Volume: 5 Issue: 9 Pages: 1459-1471
  • DOI: 10.1016/j.ekir.2020.06.011
  • Peer Reviewed / Open Access
• [Journal Article] The relationship between liver cyst volume and QOL in Japanese ADPKD patients. (2020)
  • Author(s): Muto S, Ando M, Nishio S, Hanaoka K, Ubara Y, Narita I, Kamura K, Mochizuki T, Tsuchiya K, Tsuruya K, Horie S
  • Journal Title: Clin Exp Nephrol. Volume: 24 Issue: 4 Pages: 314-322
  • DOI: 10.1007/s10157-019-01830-6
  • Peer Reviewed / Open Access
• [Journal Article] Erectile Dysfunction is Predictive Symptom for Poor Semen in Newlywed Men in Japan (2020)
  • Author(s): Tsujimura Akira、Hiramatsu Ippei、Nagashima Yuki、Ishikawa Keisuke、Uesaka Yuka、Nozaki Taiji、Ogishima Tatsuya、Shirai Masato、Terai Kazutaka、Kobayashi Kazuhiro、Horie Shigeo
  • Journal Title: Sexual Medicine Volume: 8 Issue: 1 Pages: 21-29
  • DOI: 10.1016/j.esxm.2019.09.005
  • Peer Reviewed
• [Journal Article] Significant association between urethral length measured by magnetic resonance imaging and urinary continence recovery after robot-assisted radical prostatectomy (2019)
  • Author(s): Kitamura Kosuke、China Toshiyuki、Kanayama Mayuko、Nagata Masayosi、Isotani Shuji、Wakumoto Yoshiaki、Muto Satoru、Ide Hisamitsu、Horie Shigeo
  • Journal Title: Prostate International Volume: 7 Issue: 2 Pages: 54-59
  • DOI: 10.1016/j.prnil.2018.06.003
  • Peer Reviewed
• [Journal Article] Endurological treatment trend of upper urinary urolithiasis in Japan from the Japanese Diagnosis Procedure Combination Database (2019)
  • Author(s): Isotani Shuji、Noma Yasuhiro、Wakumoto Yoshiaki、Muto Satoru、Horie Shigeo
  • Journal Title: International Journal of Urology Volume: 26 Issue: 10 Pages: 1007-1008
  • DOI: 10.1111/iju.14048
  • Peer Reviewed
• [Journal Article] Combination therapy with antioxidants improves total motile sperm counts: A Preliminary Study (2019)
  • Author(s): Terai Kazutaka、Horie Shigeo、Fukuhara Shinichiro、Miyagawa Yasushi、Kobayashi Kazuhiro、Tsujimura Akira
  • Journal Title: Reproductive Medicine and Biology Volume: 19 Issue: 1 Pages: 89-94
  • DOI: 10.1002/rmb2.12308
  • Peer Reviewed
• [Journal Article] ‘Trifecta’ outcomes of robot-assisted partial nephrectomy: a large Japanese multicenter study (2019)
  • Author(s): Furukawa Junya、Kanayama Hiroomi、Azuma Haruhito、Inoue Keiji、Kobayashi Yasuyuki、Kashiwagi Akira、Segawa Takehiko、Takahashi Yoshihito、Horie Shigeo、Ogawa Osamu、Takenaka Atsushi、Shiroki Ryoichi、Tanabe Kazunari、Fujisawa Masato
  • Journal Title: International Journal of Clinical Oncology Volume: 25 Issue: 2 Pages: 347-353
  • DOI: 10.1007/s10147-019-01565-0
  • Peer Reviewed
• [Journal Article] Factors contributing to the ceiling effect of the EQ-5D-5L: an analysis of patients with prostate cancer judged “no-problems” (2019)
  • Author(s): Murasawa Hideki、Sugiyama Takayuki、Matsuoka Yuki、Okabe Takashi、Wakumoto Yoshiaki、Tanaka Nobumichi、Sugimoto Mikio、Oyama Masafumi、Fujimoto Kiyohide、Horie Shigeo、Funagoshi Masaru、Arakawa Ichiro、Noto Shinichi、Shimozuma Kojiro
  • Journal Title: Quality of Life Research Volume: 29 Issue: 3 Pages: 755-763
  • DOI: 10.1007/s11136-019-02316-4
  • Peer Reviewed / Open Access
• [Journal Article] Results of Phase 1 study on cytoreductive radical prostatectomy in men with newly diagnosed metastatic prostate cancer (2019)
  • Author(s): Yuh Bertram E.、Kwon Young Suk、Shinder Brian M.、Singer Eric A.、Jang Thomas L.、Kim Sinae、Stein Mark N.、Mayer Tina、Ferrari Anna、Lee Nara、Parikh Rahul R.、Ruel Nora、Kim Wun-Jae、Horie Shigeo、Byun Seok-Soo、Ahlering Thomas E.、Kim Isaac Yi
  • Journal Title: Prostate International Volume: 7 Issue: 3 Pages: 102-107
  • DOI: 10.1016/j.prnil.2018.10.002
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Health utility and health related quality of life of Japanese prostate cancer patients according to progression status measured using EQ-5D-5L and FACT-P (2019)
  • Author(s): Murasawa H, Sugiyama T, Matsuoka Y, Okabe T, Hino A, Tanaka N, Sugimoto M, Oyama M, Fujimoto K, Horie S, Noto S, Shimozuma K
  • Journal Title: Qual Lif Res Volume: - Issue: 9 Pages: 1-9
  • DOI: 10.1007/s11136-019-02184-y
  • Peer Reviewed
• [Journal Article] Sarcopenia is a poor prognostic factor of castration-resistant prostate cancer treated with docetaxel therapy (2019)
  • Author(s): Ohtaka Ayako、Aoki Hiroaki、Nagata Masayoshi、Kanayama Mayuko、Shimizu Fumitaka、Ide Hisamitsu、Tsujimura Akira、Horie Shigeo
  • Journal Title: Prostate International Volume: 7 Issue: 1 Pages: 9-14
  • DOI: 10.1016/j.prnil.2018.04.002
  • Peer Reviewed
• [Journal Article] The role of hormone therapy and chemotherapy in oligometastatic prostate cancer (2019)
  • Author(s): Miura Yuji、Horie Shigeo
  • Journal Title: ESMO Open Volume: 4 Pages: e000471-e000471
  • DOI: 10.1136/esmoopen-2018-000471
  • Peer Reviewed
• [Journal Article] The incidence, mortality, and risk factors of prostate cancer in Asian men (2019)
  • Author(s): Ha Chung Byung、Horie Shigeo、Chiong Edmund
  • Journal Title: Prostate International Volume: 7 Issue: 1 Pages: 1-8
  • DOI: 10.1016/j.prnil.2018.11.001
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] The Surge in the Number of Circulating Tumor Cells Following Treatment with Sunitinib for Metastatic Renal Cell Carcinoma (2018)
  • Author(s): Nagaya Naoya、Kanayama Mayuko、Nagata Masayoshi、Horie Shigeo
  • Journal Title: Internal Medicine Volume: 57 Issue: 18 Pages: 2695-2700
  • DOI: 10.2169/internalmedicine.0663-17
  • NAID: 130007484141
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2018-09-15
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Polycystic kidney disease (2018)
  • Author(s): Bergmann Carsten、Guay-Woodford Lisa M.、Harris Peter C.、Horie Shigeo、Peters Dorien J. M.、Torres Vicente E.
  • Journal Title: Nature Reviews Disease Primers Volume: 4 Issue: 1 Pages: 1-24
  • DOI: 10.1038/s41572-018-0047-y
  • NAID: 40015472723
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] A potentially crucial role of the PKD1 C-terminal tail in renal prognosis (2018)
  • Author(s): Higashihara Eiji、Horie Shigeo、Kinoshita Moritoshi、Harris Peter C.、Okegawa Takatsugu、Tanbo Mitsuhiro、Hara Hidehiko、Yamaguchi Tsuyoshi、Shigemori Kaori、Kawano Haruna、Miyazaki Isao、Kaname Shinya、Nutahara Kikuo
  • Journal Title: Clinical and Experimental Nephrology Volume: 22 Issue: 2 Pages: 395-404
  • DOI: 10.1007/s10157-017-1477-7
  • Peer Reviewed
• [Journal Article] Effect of Lepidium meyenii on in vitro fertilization via improvement in acrosome reaction and motility of mouse and human sperm (2018)
  • Author(s): Aoki Yusuke、Tsujimura Akira、Nagashima Yuki、Hiramatsu Ippei、Uesaka Yuka、Nozaki Taiji、Ogishima Tatsuya、Shirai Masato、Shoyama Yukihiro、Tanaka Hiromitsu、Horie Shigeo
  • Journal Title: Reproductive Medicine and Biology Volume: 18 Issue: 1 Pages: 57-64
  • DOI: 10.1002/rmb2.12251
  • Peer Reviewed / Open Access
• [Journal Article] Anabolic-androgenic steroids: procurement and administration practices of doping athletes (2018)
  • Author(s): Fink Julius、Schoenfeld Brad Jon、Hackney Anthony C.、Matsumoto Masahito、Maekawa Takahiro、Nakazato Koichi、Horie Shigeo
  • Journal Title: The Physician and Sportsmedicine Volume: 47 Issue: 1 Pages: 10-14
  • DOI: 10.1080/00913847.2018.1526626
  • Peer Reviewed / Open Access
• [Journal Article] Clinical evaluation of two consecutive UroVysion fluorescence in situ hybridization tests to detect intravesical recurrence of bladder cancer: a prospective blinded comparative study in Japan (2018)
  • Author(s): Kojima Takahiro、Nishiyama Hiroyuki、Ozono Seiichiro、Hinotsu Shiro、Keino Naoto、Yamaguchi Akito、Sakai Hideki、Enomoto Yutaka、Horie Shigeo、Fujimoto Kiyohide、Matsuyama Hideyasu、Okamura Takehiko、Kanimoto Yusuke、Oya Mototsugu、Nonomura Norio、Naito Seiji、Akaza Hideyuki
  • Journal Title: International Journal of Clinical Oncology Volume: 23 Issue: 6 Pages: 1140-1147
  • DOI: 10.1007/s10147-018-1311-6
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Prospective study of robotic partial nephrectomy for renal cancer in Japan: Comparison with a historical control undergoing laparoscopic partial nephrectomy (2018)
  • Author(s): Tanaka Kazushi、Teishima Jun、Takenaka Atsushi、Shiroki Ryoichi、Kobayashi Yasuyuki、Hattori Kazunori、Kanayama Hiro-omi、Horie Shigeo、Yoshino Yasushi、Fujisawa Masato
  • Journal Title: International Journal of Urology Volume: 25 Issue: 5 Pages: 472-478
  • DOI: 10.1111/iju.13544
• [Journal Article] Efficacy and safety of 3-month dosing regimen of degarelix in Japanese subjects with prostate cancer: A phase III study (2018)
  • Author(s): Ozono Seiichiro、Tsukamoto Taiji、Naito Seiji、Horie Shigeo、Ohashi Yasuo、Uemura Hiroji、Yokomizo Yumiko、Fukasawa Satoshi、Kusuoka Hidehito、Akazawa Rio、Saito Masako、Akaza Hideyuki
  • Journal Title: Cancer Science Volume: 109 Issue: 6 Pages: 1920-1929
  • DOI: 10.1111/cas.13600
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Short-term outcomes of the transvaginal minimal mesh procedure for pelvic organ prolapse (2018)
  • Author(s): Takazawa Naoko、Fujisaki Akiko、Yoshimura Yasukuni、Tsujimura Akira、Horie Shigeo
  • Journal Title: Investigative and Clinical Urology Volume: 59 Issue: 2 Pages: 133-133
  • DOI: 10.4111/icu.2018.59.2.133
• [Journal Article] Modulation of AKR1C2 by Curcumin Decreases Testosterone Production in Prostate Cancer (2018)
  • Author(s): Ide H, Lu Y, Noguchi T, Muto S, Okada H, Kawato S and Horie S
  • Journal Title: Cancer Science Volume: 109 Issue: 4 Pages: 1230-1238
  • DOI: 10.1111/cas.13517
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] T1b症例におけるロボット支援腹腔鏡下腎部分切除 (RAPN)の周術期成績の検討． (2019)
  • Author(s): 木村僚喜，磯谷周治，野間康央，知名俊幸，北村香介，永田政義，松下一仁，和久本芳彰，武藤 智，堀江重郎．
  • Organizer: 第33回日本泌尿器内視鏡学会総会
• [Presentation] ロボット支援腹腔鏡下前立腺摘除術(RARP)における術後リンパ漏の予防的手術手技． (2019)
  • Author(s): 知名俊幸，木村僚喜，青木悠介，北村香介，松下一仁，永田政義，磯谷周治，和久本芳彰，武藤 智，堀江重郎．
  • Organizer: 第33回日本泌尿器内視鏡学会総会
• [Presentation] TULにおけるDifficult ureterの検討． (2019)
  • Author(s): 野間康央，磯谷周治，平野 央，金子寿夫，黒須春香，永田政義，中川由紀，和久本芳彰，武藤 智，堀江重郎．
  • Organizer: 第33回日本泌尿器内視鏡学会総会
• [Presentation] 高難度症例(high complex tumor) に対するロボット支援腎部分切除術(RAPN)の検討． (2019)
  • Author(s): 磯谷周治，木村僚喜，知名俊幸，野間康央，北村香介，永田政義，松下一仁，和久本芳彰，武藤 智，堀江重郎．
  • Organizer: 第33回日本泌尿器内視鏡学会総会
• [Presentation] 尿路上皮癌に対するペンブロリズマブ療法による治療効果に与えるサルコペニアの影響についての検討． (2019)
  • Author(s): 芦澤 健，村元啓仁，村上 敦，平野 央，家田健史，北村香介，松下一仁，武藤 智，堀江重郎．
  • Organizer: 日本泌尿器腫瘍学会第5回学術集会．
• [Presentation] 当院における転移性腎細胞がんに対して使用したNivolumab + Iplimumab併用療法に起因する免疫関連有害事象の経験． (2019)
  • Author(s): 青木悠介，永田政義，木村僚喜，知名俊幸，北村香介，松下一仁，磯谷周治，和久本芳彰，武藤 智，堀江重郎．
  • Organizer: 日本泌尿器腫瘍学会第5回学術集会．
• [Presentation] 密封小線源療法後のPSA再発に対する救済療法． (2019)
  • Author(s): 和久本芳彰，村元啓仁，青木悠介，芦澤 健，日野安見子，河野春奈，久能木裕明，笹井啓資，武藤 智，堀江重郎．
  • Organizer: 日本泌尿器腫瘍学会第5回学術集会．
• [Presentation] 全尿路上皮内癌患者におけるGC療法の効果の検討． (2019)
  • Author(s): 北村香介，武藤 智，芦澤 健，平野 央，松下一仁，永田政義，磯谷周治，中川由紀，和久本芳彰，堀江重郎．
  • Organizer: 日本泌尿器腫瘍学会第5回学術集会．
• [Presentation] 当院における免疫チェックポイント阻害剤関連筋炎の2例． (2019)
  • Author(s): 木村僚喜，青木悠介，知名俊幸，河野春奈，日野安見子，北村香介，松下一仁，永田政義，磯谷周治，中川由紀，和久本芳彰，武藤 智，堀江重郎．
  • Organizer: 第84回日本泌尿器科学会東部総会．
• [Presentation] 副腎皮質癌の4例の臨床的検討． (2019)
  • Author(s): 中村 聡，高畑創平，村元啓仁，古謝将之，家田健史，知名俊幸，北村香介，永田政義，磯谷周治，和久本芳彰，武藤 智，堀江重郎．
  • Organizer: 第84回日本泌尿器科学会東部総会．
• [Presentation] 副腎神経内分泌腫瘍の1例． (2019)
  • Author(s): 村元啓仁，野間康央，知名俊幸，北村香介，永田政義，磯谷周治，和久本芳彰，武藤 智，後藤広昌，荒川 敦，堀江重郎．
  • Organizer: 第630回日本泌尿器科学会東京地方会．
• [Presentation] DPC（Diagnosis Procedure Combination）データベースをもちいた、日本の上部尿路結石に対する入院手術療法についての解析 (2019)
  • Author(s): 磯谷周治，野間康央，芦澤 健，子安洋輝，家田健史，知名俊幸，北村香介，河野春奈，永田政義，和久本芳彰，武藤 智，堀江重郎．
  • Organizer: 第107回日本泌尿器科学会総会．
• [Presentation] 密封小線源療法後のPSA再発に対する救済療法―Seed re-implantationーによるFocal therapyは有効か (2019)
  • Author(s): 和久本芳彰，中村 聡，高畑創平，福田和康，日野安見子，長屋直哉，北村香介，河野春奈，土井直人，久能木裕明，笹井啓資，武藤 智，堀江重郎．
  • Organizer: 第107回日本泌尿器科学会総会．
• [Presentation] 経尿道的ホルミニウムレーザー前立腺核出術後に診断された偶発前立腺癌の検討 (2019)
  • Author(s): 野間康央，磯谷周治，芦澤 健，子安洋輝，家田健史，知名俊幸，永田政義，和久本芳彰，武藤 智，堀江重郎．
  • Organizer: 第107回日本泌尿器科学会総会．
• [Presentation] 当院における経皮的腎結石手術（PNL）の治療成績に関与する因子の検討， (2019)
  • Author(s): 芦澤 健，小笠大起，三好悠斗，小林拓郎，黒澤 誠，長屋直哉，野間康央，子安洋輝，家田健史，北村香介，磯谷周治，武藤 智，堀江重郎．
  • Organizer: 第107回日本泌尿器科学会総会．
• [Presentation] ロボット支援回腸導管造設における対空内尿路変更 (2019)
  • Author(s): 北村香介，黒澤 誠，長屋直哉，芦澤 健，子安洋輝，野間康央，家田健史，知名俊幸，永田政義，磯谷周治，和久本芳彰，武藤 智，堀江重郎．
  • Organizer: 第107回日本泌尿器科学会総会．
• [Presentation] 5-ALA含有食品摂取における男性更年期障害に対する改善効果の検討， (2019)
  • Author(s): 子安洋輝，小笠大起，小林拓郎，三好悠斗，黒澤 誠，長屋直哉，福田和康，芦澤 健，野間康央，磯谷周治，武藤 智，和久本芳彰，堀江重郎．
  • Organizer: 第107回日本泌尿器科学会総会．
• [Presentation] 進行性転移性膀胱癌に対するPembrolizumabの初期投与経験 (2019)
  • Author(s): 黒澤 誠，家田健史，野間康央，子安洋輝，知名俊幸，北村香介，永田政義，和久本芳彰，武藤 智，堀江重郎．
  • Organizer: 第107回日本泌尿器科学会総会．
• [Presentation] 初回前立腺生検で陰性だった症例の再生検に関する臨床的検討， (2019)
  • Author(s): 中村 聡，平野 央，北村香介，高澤直子，永田政義，磯谷周治，和久本芳彰，武藤 智，磯部英行，堀江重郎．
  • Organizer: 第107回日本泌尿器科学会総会．
• [Presentation] 腸管利用による膀胱全摘除術後のイレウス予測因子の検討． (2019)
  • Author(s): 家田健史，武藤 智，脇田春彦，黒澤 誠，野間康央，高畑創平，子安洋輝，知名俊幸，北村香介，永田政義，磯谷周治，和久本芳彰，堀江重郎．
  • Organizer: 第107回日本泌尿器科学会総会．
• [Presentation] 緊急手術を要した原発性アルドステロン症の1例． (2019)
  • Author(s): 黒澤 誠，家田健史，小林拓郎，小笠大起，三好悠斗，福田和泰，芦澤 健，子安洋輝，野間康央，知名俊幸，北村香介，河野春奈，日野安見子，永田政義，磯谷周治，和久本芳彰，武藤 智，土井直人，堀江重郎．
  • Organizer: 第629回日本泌尿器科学会東京地方会．
• [Presentation] Prostate-specific membrane antigen in circulating tumor cells is a new poor prognostic marker for castration-resistant prostate cancer (2019)
  • Author(s): Shigeo Horie
  • Organizer: JW Marriott
  • Int'l Joint Research
• [Presentation] Cutting edge of focal therapy for prostate cancer (2019)
  • Author(s): Shigeo Horie
  • Organizer: 11th International Symposium on Focal Therapy and Imaging in Prostate and Kidney Cancer
  • Int'l Joint Research
• [Presentation] Predictive factors for pathological response in patients receiving neoadjuvant chemotherapy prior to radical cystectomy. (2018)
  • Author(s): Ieda T, Muto S, Noma Y, Kanayama M, Koyasu H, Takahata S, China T, Kitamura K, Nagata M, Isotani S, Wakumoto Y, Horie S.
  • Organizer: 16th Urological Association of Asia Congress 2018.
  • Int'l Joint Research
• [Presentation] Benign Prostatic Hyperplasia (2018)
  • Author(s): Shigeo Horie
  • Organizer: 16th Urological Association of Asia Congress 2018.
  • Int'l Joint Research
• [Presentation] Current strategy for the treatment of CRPC (2018)
  • Author(s): Shigeo Horie
  • Organizer: 日台泌尿器腫瘍学会
  • Int'l Joint Research
• [Presentation] Prostate Cancer (2018)
  • Author(s): Shigeo Horie
  • Organizer: Asian Pacific Society of Uro-oncology 2018
  • Int'l Joint Research
• [Presentation] Bladder Cancer (2018)
  • Author(s): Shigeo Horie
  • Organizer: Asian Pacific Society of Uro-oncology 2018
  • Int'l Joint Research
• [Presentation] ProstateCancer (2018)
  • Author(s): Shigeo Horie
  • Organizer: Asian Pacific Society of Uro-oncology 2018
  • Int'l Joint Research
• [Presentation] AR-V7 in Prostate Cancer (2018)
  • Author(s): Shigeo Horie
  • Organizer: Asian Pacific Prostate Society 2018
  • Int'l Joint Research
• [Presentation] 3D Printing use in Surgery Plannning (2018)
  • Author(s): Shigeo Horie
  • Organizer: Asian Pacific Prostate Society 2018
  • Int'l Joint Research
• [Presentation] Drug Development of a Rare Inherited Diseas (2018)
  • Author(s): Shigeo Horie
  • Organizer: Regional Asian Clinical Trial Annual Forum 2018
  • Int'l Joint Research
• [Presentation] Urology Parallel session (2018)
  • Author(s): Shigeo Horie
  • Organizer: 4th Asian Congress of Robotic and Laparoscopic Surgery
  • Int'l Joint Research
• [Presentation] PSA screening and diagnosis (2018)
  • Author(s): Shigeo Horie
  • Organizer: European Society of Medical Oncology Preceptorship on Proteste Cancer
  • Int'l Joint Research
• [Presentation] Multidisciplinary Tumour Board session (2018)
  • Author(s): Shigeo Horie
  • Organizer: European Society of Medical Oncology Asia 2018
  • Int'l Joint Research
• [Presentation] Mini oral session of Genitourinary tumours (2018)
  • Author(s): Shigeo Horie
  • Organizer: European Society of Medical Oncology Asia 2018
  • Int'l Joint Research
• [Presentation] LegendsLecture (2018)
  • Author(s): Shigeo Horie
  • Organizer: The 35th KOREA-JAPAN Urological Congress
  • Int'l Joint Research
• [Presentation] New Horizen of Laser Surgery (2018)
  • Author(s): Shigeo Horie
  • Organizer: The 35th KOREA-JAPAN Urological Congress
  • Int'l Joint Research
• [Presentation] Precision surgery for urologicmalignancy (2018)
  • Author(s): Shigeo Horie
  • Organizer: 2nd Asian Urological Oncology Forum/11th annual meeting of TUOA
  • Int'l Joint Research
• [Presentation] ADPKDにおける脳動脈瘤，心弁膜症の実態 (2018)
  • Author(s): 河野春奈，武藤 智，堀江重郎
  • Organizer: 第48回日本腎臓学会東部学術大会
• [Presentation] 多発性嚢胞腎患者全国登録による多施設共同研究（J-PKDレジストリー研究）：最終報告 (2018)
  • Author(s): 武藤 智，望月俊雄，土谷 健，西尾妙織，花岡一成，乳原善文，奴田原紀久男，鶴屋和彦，丸山彰一，成田一衛，堀江重郎
  • Organizer: 第61回日本腎臓学会学術総会
• [Presentation] ADPKDに対するトルバプタンの総投与量と治療効果の検討 (2018)
  • Author(s): 河野春奈，武藤 智，堀江重郎
  • Organizer: 第61回日本腎臓学会学術総会
• [Presentation] ,ADPKD modifier gene (2018)
  • Author(s): 堀江重郎
  • Organizer: 第61回日本腎臓学会学術総会
• [Book] 寿命の9割は「尿」で決まる (2018)
  • Author(s): 堀江 重郎
  • Total Pages: 192
  • Publisher: SBクリエイティブ
  • ISBN: 4797390913
• [Book] 堀江重郎対談集 いのち――人はいかに生きるか (2018)
  • Author(s): 堀江 重郎
  • Total Pages: 284
  • Publisher: かまくら春秋社
  • ISBN: 4774007587