Development of the new system to appropriately assess health related quality of life in patients with bladder cancer survivor using patient reported outcome.
| Project/Area Number |
18K09155
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Review Section |
Basic Section 56030:Urology-related
|
|---|
| Research Institution | Hokkaido University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
伊藤 陽一 統計数理研究所, データ科学研究系, 教授 (10334236)
安部 崇重 北海道大学, 医学研究院, 准教授 (10399842)
篠原 信雄 北海道大学, 医学研究院, 教授 (90250422)
小笠原 克彦 北海道大学, 保健科学研究院, 教授 (90322859)
|
|---|
| Project Period (FY) |
2018-04-01 – 2021-03-31
|
| Project Status |
Completed (Fiscal Year 2020)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | 膀胱がん / Quality of life / Patient reported outcome / 膀胱がん特異的QOL調査票 / qualityof life / Bladder cancer |
|---|
| Outline of Final Research Achievements |
We validated a Japanese version of the bladder cancer index (BCI) as a tool for measuring health-related quality of life (HRQOL) in bladder cancer patients treated with various surgical procedures. In addition, we characterized health related quality of life (HRQOL) in Japanese patients after bladder cancer surgery and to perform cross-cultural comparison between Japanese and American patients.
Although revisions are needed to make it easier for elderly patients to comprehend, we confirmed the reliability and validity of the Japanese BCI. The Japanese BCI could be used for cross-cultural assessments of HRQOL in bladder cancer patients. HRQOL outcomes following treatment of bladder cancer in Japan are comparable to those in the USA, except for sexual functioning and sexual bother. The BCI can be used for cross-cultural assessments of HRQOL in bladder cancer patients.
|
| Academic Significance and Societal Importance of the Research Achievements |
世界的に見ても非常に大規模な多施設共同研究となっており、本研究の成果により今後治療を受ける膀胱がん患者の治療選択や治療後のHRQOLに関する情報提供において大きな恩恵がもたらされると考える。その他の調査項目として、SF-12、EQ-5D、FACT-BLを用い、BCIを含めたこれらのHRQOL調査票データと臨床データの比較解析により、腫瘍の進行度、治療方法が治療後のHRQOLや晩期合併症の種類・程度とどのように関連しているかを明らかにすることができた。今回の研究成果により、包括的なHRQOL評価法を確立する上での基盤データを得ることができたと考えられる。
|
Report
(4 results)
Research Products
(27 results)
-
[Journal Article] Comparison of Health-Related Quality of Life Between Japanese and American Patients with Bladder Cancer as Measured by a Newly Developed Japanese Version of the Bladder Cancer Index2021
Author(s)
Osawa T, Wei JT, Abe T, Honda M, Rew, KT, Dunn R, Yamada S, Furumido J, Kikuchi H, Matsumoto R, Sato Y, Harabayashi T, Takada N, Minami K, Morita K, Kashiwagi A, Fukuhara S, Murai S, Ito YM, Ogasawara K, Shinohara N
-
Journal Title
Bladder Cancer
Volume: 7
Issue: 1
Pages: 61-69
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
[Journal Article] Health-related quality of life in Japanese patients with bladder cancer measured by a newly developed Japanese version of the Bladder Cancer Index2020
Author(s)
Osawa T, Wei JT, Abe T, Honda M, Yamada S, Furumido J, Kikuchi H, Matsumoto R, Hirakawa K, Sato Y, Sasaki Y, Harabayashi T, Takada N, Minami K, Tanaka H, Morita K, Kashiwagi A, Miyajima N, Akino T, Murai S, Ito YM, Fukuhara S, Ogasawara K, Shinohara N
-
Journal Title
International Journal of Clinical Oncology
Volume: 25
Issue: 12
Pages: 2090-2098
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Treatment patterns and outcomes in patients with unresectable or metastatic renal cell carcinoma in Japan.2019
Author(s)
Harada K, Nozawa M, Uemura M, Tatsugami K, Osawa T, Yamana K, Kimura G, Fujisawa M, Nonomura N, Eto M, Shinohara N, Tomita Y, Kondo Y, Ochi K, Anazawa Y, Uemura H.
-
Journal Title
Int J Urol.
Volume: 26
Issue: 2
Pages: 202-210
DOI
Related Report
Peer Reviewed
-
-
[Journal Article] Outcome and prognostic factors in metastatic urothelial carcinoma patients receiving second-line chemotherapy: an analysis of real-world clinical practice data in Japan.2018
Author(s)
Matsumoto R, Abe T, Ishizaki J, Kikuchi H, Harabayashi T, Minami K, Sazawa A, Mochizuki T, Akino T, Murakumo M, Osawa T, Maruyama S, Murai S, Shinohara N.
-
Journal Title
Jpn J Clin Oncol.
Volume: 48
Issue: 8
Pages: 771-776
DOI
NAID
Related Report
Peer Reviewed / Open Access
-
-
-
[Journal Article] Comparative study of lymph node dissection, and oncological outcomes of laparoscopic and open radical nephroureterectomy for patients with urothelial carcinoma of the upper urinary tract undergoing regional lymph node dissection.2018
Author(s)
Abe T, Kondo T, Harabayashi T , Takada N, Matsumoto R, Osawa T, Minami K, Nagamori S, Maruyama S, Murai S, Tanabe K, Shinohara N
-
Journal Title
Jpn J Clin Oncol
Volume: 48
Issue: 11
Pages: 1001-1011
DOI
NAID
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
-
-
-
-
