Development of glycomolecule-based liquid biopsy marker for evaluation of prostate cancer malignancy
| Project/Area Number |
18K09157
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 56030:Urology-related
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| Research Institution | Hirosaki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
畠山 真吾 弘前大学, 医学研究科, 准教授 (10400136)
飛澤 悠葵 弘前大学, 医学研究科, 助教 (70623768)
大山 力 弘前大学, 医学研究科, 教授 (80282135)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | リキッドバイオプシー / 前立腺癌 / 糖転移酵素 / 糖鎖 |
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| Outline of Final Research Achievements |
In this study, we evaluate the glycosyltransferase gene expression in cell free DNA as a biomarker of prostate cancer malignancy or as a surrogate biomarker of treatment of prostate cancer. The expression level of LacdiNAc-glycan synthesis related B4GALNT4 gene significantly correlate with castration resistant status of prostate cancer suggesting the B4GALNT4 gene expression in cfDNA as a prognostic biomarker of castration resistant prostate cancer.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究で得られたcfDNA中の糖転移酵素の発現定量による去勢抵抗性前立腺癌の予後予測法は低侵襲で患者の全身状況の「現状」をより正確に反映することが可能となる。特に骨転移が多く針生検による、組織検体採取が難しい去勢抵抗性前立腺癌の予後予測および治療効果モニタリングには、低侵襲なLiquid biopsyベースのバイオマーカーが非常に有用であると考えられる。cfDNA中の糖転移酵素バイオマーカーは、これまでに報告されておらず、学術的意義は高く、本バイオマーカーの実用化は、去勢抵抗性前立腺癌の治療効果の向上、患者のQOL向上および医療費軽減につながり、社会的意義は大きい。
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Report
(4 results)
Research Products
(16 results)
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[Presentation] Comparison with diagnostic performance between aberrant glycosylated S2,3PSA test and conventional PSA tests2018
Author(s)
Tohru Yoneyama, Tomokazu Ishikawa, Yuki Tobisawa, Shingo Hatakeyama, Mutsuhiro Date, Kenji Nakamura, Shintaro Narita, Koji Mitsuzuka, Wilhelmina Duivenvoorden, Jehonathan H. Pinthus, Yasuhiro Hashimoto, Takuya Koie, Tomonori Habuchi, Yoichi Arai and Chikara Ohyama
Organizer
American Urological Association 2018
Related Report
Int'l Joint Research
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[Presentation] Clinical significant prostate cancer diagnostic performance of LacdiNAc-Prostate-Specific Antigen Glycoisomer Assay at Initial Prostate Biopsy: Retrospective Multi-Institutional Study2018
Author(s)
Tohru Yoneyama, Yuki Tobisawa, Tomonori Kaneko, Takatoshi Kaya, Shingo Hatakeyama, Koji Mitsuzuka, Wilhelmina Duivenvoorden, Jehonathan H. Pinthus, Yasuhiro Hashimoto, Akihiro Ito, Takuya Koie, Yoshihiko Suda, Robert A. Gardiner, and Chikara Ohyama
Organizer
European Association of Urology 2019
Related Report
Int'l Joint Research
