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Novel strategy targeting mechanosensor in the bladder urothelium for treatment of unaderactive bladder

Research Project

Project/Area Number 18K09188
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 56030:Urology-related
Research InstitutionUniversity of Yamanashi

Principal Investigator

KIRA Satoru  山梨大学, 大学院総合研究部, 助教 (10530115)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords泌尿器科 / 低活動膀胱 / 伸展受容器 / 泌尿器 / 泌尿器科学 / 膀胱上皮
Outline of Final Research Achievements

Based on bladder contractility index and Bladder Outlet Obstruction Index in urodynamic study, Detrusor Underactivity (DU) and Control group were defined. We collected the urothelial cells in the urine samples of all patients and analyzed the mRNA expression of each subtypes of mechanosensory molecule using quantitive real-time reverse transcription polymerase chain reaction. The mRNA expression of TRPM2 and Piezo 1 were lower level in DU group than in Contorl group. These molecules may be involved with the pathogenesis of DU.

Academic Significance and Societal Importance of the Research Achievements

低活動膀胱は、その病態生理もさることながら現時点では確立された定義や診断基準すら定まっていないのが現状である。また、本疾患の原因の一つとして、尿意知覚異常を代表とする尿意求心路異常が注目を集めているが、詳細までは解明されていない。本研究の成果からは、低活動膀胱における尿意求心路異常として膀胱尿路上皮伸展受容器の発現異常が示唆されている。本研究の成果が低活動膀胱の改善に導く可能性を示し、新規治療薬の端緒となりうると考えられた。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (8 results)

All 2020 2019

All Journal Article (4 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results,  Open Access: 1 results) Presentation (4 results)

  • [Journal Article] Urinary metabolites identified using metabolomic analysis as potential biomarkers of nocturia in elderly men.2020

    • Author(s)
      Kira S, Mitsui T, Miyamoto T, Ihara T, Nakagomi H, Hashimoto Y, Takamatsu H, Tanahashi M, Takeda M, Tsuchiya S, Sawada N, Takeda M
    • Journal Title

      World J Urol

      Volume: - Issue: 10 Pages: 2563-2569

    • DOI

      10.1007/s00345-019-03042-9

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Feasibility and necessity of the fourth arm of the da Vinci Sisurgical system for robot-assisted partial nephrectomy2020

    • Author(s)
      Satoru Kira, Takahiko Mitsui, Norifumi Sawada, Hiroshi Nakagomi, Tatsuya Ihara, Nobuhiro Takahashi, Masayuki Takeda
    • Journal Title

      The international Journal of Medical Robotics and Computer Assisted Surgery.

      Volume: 16 Issue: 3

    • DOI

      10.1002/rcs.2092

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Liquid chromatography?mass spectrometry identification of serum biomarkers for nocturia in aged men2019

    • Author(s)
      Kira Satoru、Mitsui Takahiko、Miyamoto Tatsuya、Ihara Tatsuya、Nakagomi Hiroshi、Hashimoto Yuka、Takamatsu Hajime、Tanahashi Masayuki、Takeda Masahiro、Sawada Norifumi、Andersson Karl-Erik、Takeda Masayuki
    • Journal Title

      World Journal of Urology

      Volume: in press Issue: 10 Pages: 2199-2205

    • DOI

      10.1007/s00345-019-02647-4

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Metabolomics Analysis of Blood Identifies Potential Biomarkers and Possible Treatment Targets for Nocturia2019

    • Author(s)
      Satoru Kira, Takahiko Mitsui, Tatsuya Miyamoto, Tatsuya Ihara, Hiroshi Nakagomi, Yuka Hashimoto, Hajime Takamatsu, Masayuki Tanahashi, Masahiro Takeda, Norifumi Sawada, Masayuki Takeda
    • Journal Title

      Therapeutic Advances in Urology

      Volume: 11 Pages: 1-7

    • DOI

      10.1177/1756287219850087

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] メタボロミクス解析を用いた尿意切迫感に関連する新規標的分子の網羅的探索2020

    • Author(s)
      吉良聡、三井貴彦、宮本達也、中込宙史、井原達矢、橋本由佳、澤田智史、武田正之
    • Organizer
      第27回日本排尿機能学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 前立腺肥大症に対するTUEB術後2年間の尿流動体検査を含めた臨床的検討2020

    • Author(s)
      澤田友史、井原達也、佐藤毅、古屋良太、矢野文彬、望月孝規、吉良聡、中込宙史、三井貴彦、武田正之
    • Organizer
      第27回日本排尿機能学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 新規診断ツールとしての尿中上皮細胞の可能性2019

    • Author(s)
      吉良 聡、三井 貴彦、澤田 智史、中込 宙史、井原 達矢、土屋 幸子、 武田 正之
    • Organizer
      第26回日本排尿機能学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 侵襲的UDSのサローゲートマーカーとしての尿中細胞の可能性2019

    • Author(s)
      吉良 聡
    • Organizer
      第107回日本泌尿器科学会総会
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2022-01-27  

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