Novel strategy targeting mechanosensor in the bladder urothelium for treatment of unaderactive bladder
Project/Area Number |
18K09188
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 56030:Urology-related
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Research Institution | University of Yamanashi |
Principal Investigator |
KIRA Satoru 山梨大学, 大学院総合研究部, 助教 (10530115)
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Project Period (FY) |
2018-04-01 – 2021-03-31
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Project Status |
Completed (Fiscal Year 2020)
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Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 泌尿器科 / 低活動膀胱 / 伸展受容器 / 泌尿器 / 泌尿器科学 / 膀胱上皮 |
Outline of Final Research Achievements |
Based on bladder contractility index and Bladder Outlet Obstruction Index in urodynamic study, Detrusor Underactivity (DU) and Control group were defined. We collected the urothelial cells in the urine samples of all patients and analyzed the mRNA expression of each subtypes of mechanosensory molecule using quantitive real-time reverse transcription polymerase chain reaction. The mRNA expression of TRPM2 and Piezo 1 were lower level in DU group than in Contorl group. These molecules may be involved with the pathogenesis of DU.
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Academic Significance and Societal Importance of the Research Achievements |
低活動膀胱は、その病態生理もさることながら現時点では確立された定義や診断基準すら定まっていないのが現状である。また、本疾患の原因の一つとして、尿意知覚異常を代表とする尿意求心路異常が注目を集めているが、詳細までは解明されていない。本研究の成果からは、低活動膀胱における尿意求心路異常として膀胱尿路上皮伸展受容器の発現異常が示唆されている。本研究の成果が低活動膀胱の改善に導く可能性を示し、新規治療薬の端緒となりうると考えられた。
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Report
(4 results)
Research Products
(8 results)
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[Journal Article] Urinary metabolites identified using metabolomic analysis as potential biomarkers of nocturia in elderly men.2020
Author(s)
Kira S, Mitsui T, Miyamoto T, Ihara T, Nakagomi H, Hashimoto Y, Takamatsu H, Tanahashi M, Takeda M, Tsuchiya S, Sawada N, Takeda M
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Journal Title
World J Urol
Volume: -
Issue: 10
Pages: 2563-2569
DOI
Related Report
Peer Reviewed
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[Journal Article] Metabolomics Analysis of Blood Identifies Potential Biomarkers and Possible Treatment Targets for Nocturia2019
Author(s)
Satoru Kira, Takahiko Mitsui, Tatsuya Miyamoto, Tatsuya Ihara, Hiroshi Nakagomi, Yuka Hashimoto, Hajime Takamatsu, Masayuki Tanahashi, Masahiro Takeda, Norifumi Sawada, Masayuki Takeda
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Journal Title
Therapeutic Advances in Urology
Volume: 11
Pages: 1-7
DOI
Related Report
Peer Reviewed / Open Access
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