Development of novel approach for prevention of preterm birth by inhibiting cervical ripening using anti-inflammatory proteins
| Project/Area Number |
18K09220
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 56040:Obstetrics and gynecology-related
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 早産 / 妊娠 / 頸管熟化 / 抗炎症蛋白 / 炎症制御 / プロテアーゼ / 子宮頸管熟化 / SLPI / プログラニュリン / 抗プロテアーゼ |
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| Outline of Final Research Achievements |
In this study, we aimed to investigate the involvement of two anti-inflammatory proteins, progranulin (PGRN) and secretory leukocyte protease inhibitor (SLPI), in the regulation of cervical ripening and to gain new insights for the treatment of preterm birth. Analysis of mouse models of preterm birth and clinical specimens revealed that PGRN and SLPI were produced abundantly at the cervix and fetal membrane. Expression patterns at the cervix were different between PGRN and SLPI depending on the causes of preterm birth. Anti-inflammatory and anti-protease properties are shared among PGRN and SLPI, but they might play distinct roles in the regulation of cervical ripening.
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| Academic Significance and Societal Importance of the Research Achievements |
プロゲステロン作用不全と感染炎症は早産の代表的な背景機序である。しかし、臨床的にその双方を鑑別して治療の個別化に結び付けることはできていない。本研究の結果から妊婦の頸管において、PGRNおよびSLPIは異なる発現制御を受けており、そうした早産の背景原因の鑑別のためのバイオマーカー候補となりうることが示唆された。また特に、SLPIは早産の背景要因に関わらず病的頸管熟化の阻止に働くことが期待でき、子宮頸管熟化抑制という新規の着眼点からの早産治療の候補となりうる。
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Report
(4 results)
Research Products
(13 results)
