| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Mitochondrial quality control (MQC) is critical in controlling the quality of mitochondrial function and maintaining cellular health. We investigated the role of Mieap, one of the proteins that control MQC, on sperm and egg functions. Mieap-knockout induced sperm oxidative stress and markedly reduced sperm function. Mieap-knockout sperm induced embryonic growth arrest during in vitro fertilization. These results indicate that MQC is essential for sperm function and embryonic development. Unfortunately, we could not prove the association between the MQC impairment and aged-related fertility decline in sperm/egg.
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