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Development of non-invasive and effective maternal screening for congenital cytomegalovirus infection

Research Project

Project/Area Number 18K09232
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 56040:Obstetrics and gynecology-related
Research InstitutionUniversity of Miyazaki

Principal Investigator

Kaneko Masatoki  宮崎大学, 医学部, 教授 (40264387)

Co-Investigator(Kenkyū-buntansha) 鮫島 浩  宮崎大学, 学長 (50274775)
Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords先天性サイトメガロウイルス感染症 / 妊婦抗体スクリーニング / 妊婦メンタルヘルス / サイトメガロウイルス / CMV IgG avidity / 妊婦スクリーニング / 母子感染 / 周産期 / メンタルヘルスケア / 胎内感染 / ウイルス感染 / IgG avidity / 脳障害
Outline of Final Research Achievements

We showed the following results regarding the maternal CMV antibody screening; (1) The anxiety score of pregnant women with CMV IgM-positive was statistically higher than that with CMV IgM-negative. This result indicate that the mental support is required for IgM-positive women. (2) IgG avidity index (AI) is useful to detect primary maternal infection. However, IgG AI increase as gestational age advances. Thus, we indicated that IgG AI was useful to detect the maternal primary infection, when measured within 14 weeks of gestation. (3) we conducted the study to establish a model to predict high CMV IgG AI using clinical information, to contribute to the maternal mental health of CMV IgM positive pregnant women. As a result, we established a useful mathematical model that included clinical factors such as the CMV IgM titer and the pregnant women with one parity to predict a pregnant women’s likelihood of having a high CMV IgG AI with a high probability of 97%.

Academic Significance and Societal Importance of the Research Achievements

CMV IgM陽性者の不安度の高さの提示により、妊婦抗体スクリーニング時のメンタルヘルスの重要性を示した。また、CMV IgM陽性者からCMV初感染者を正確に判別するためには、IgG avidity index (AI)を妊娠14週までに検査する必要があることを示し、さらに高IgG AIを高い確率で予測する数理モデル式を開発した。この結果、妊婦スクリーニングでCMV IgMと判定された妊婦に過度の不安を長期間与えることなく、CMV IgM値と妊娠回数から胎内CMV感染のLow riskである高IgG AIを判定することを可能とし、妊婦メンタルヘルスに配慮した抗体スクリーニング確立に寄与できた。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (12 results)

All 2022 2021 2020 2019 2018

All Journal Article (7 results) (of which Peer Reviewed: 4 results,  Open Access: 4 results) Presentation (5 results) (of which Int'l Joint Research: 1 results,  Invited: 5 results)

  • [Journal Article] Low maternal immunoglobulin G avidity and single parity as adverse implications of human cytomegalovirus vertical transmission in pregnant women with immunoglobulin M positivity2021

    • Author(s)
      Masatoki Kaneko, Junsuke Muraoka, Kazaumi Kusumoto, Toshio Minematsu
    • Journal Title

      Viruses

      Volume: 13 Issue: 5 Pages: 866-866

    • DOI

      10.3390/v13050866

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] サイトメガロウイルス感染症2021

    • Author(s)
      金子政時
    • Journal Title

      臨床と微生物

      Volume: 48 Pages: 53-57

    • Related Report
      2020 Research-status Report
  • [Journal Article] A multiple regression model for predicting a high cytomegalovirus immunoglobulin G avidity level in pregnant women with IgM positivity2020

    • Author(s)
      Kaneko Masatoki、Ohhashi Masanao、Fujii Yoshinori、Minematsu Toshio、Kusumoto Kazumi
    • Journal Title

      International Journal of Infectious Diseases

      Volume: 100 Pages: 1-6

    • DOI

      10.1016/j.ijid.2020.08.034

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 妊娠と感染症:サイトメガロウイルス2020

    • Author(s)
      金子政時
    • Journal Title

      周産期医学

      Volume: 50 Pages: 1489-1491

    • Related Report
      2020 Research-status Report
  • [Journal Article] A cross-sectional study on maternal anxiety levels after cytomegalovirus screening2019

    • Author(s)
      Kanako Uehara, Masatoki Kaneko, Ayaka Matsuoka, Mana Kuroki, Toshio Minematsu
    • Journal Title

      Journal of Psychosomatic Obstetrics and Gynecology

      Volume: 40 Issue: 3 Pages: 1-6

    • DOI

      10.1080/0167482x.2019.1658734

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 妊婦サイトメガロウイルス抗体スクリーニングと妊産婦メンタルヘルスケア2019

    • Author(s)
      金子政時、松岡あやか、土谷倭子
    • Journal Title

      宮崎県医師会医学会誌

      Volume: 43

    • Related Report
      2019 Research-status Report
  • [Journal Article] サイトメガロウイルスIgM抗体陽性妊婦の外来紹介受診状況と妊娠転帰に関する後方視的検討2018

    • Author(s)
      黒木真菜、金子政時、水畑喜代子、永瀬つや子、松岡あやか
    • Journal Title

      母性衛生

      Volume: 59

    • NAID

      40021654398

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] A multiple regression model for predicting a high cytomegalovirus immunoglobulin G avidity level in pregnant women with IgM positivity2022

    • Author(s)
      Masatoki Kaneko
    • Organizer
      International Research Awards on Pediatrics, Perinatology and Child Health
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 先天性サイトメガロウイルス感染症の現状と課題2021

    • Author(s)
      金子政時
    • Organizer
      日本周産期・新生児医学会学術集会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] サイトメガロウイルス母子感染と周産期管理2018

    • Author(s)
      金子政時
    • Organizer
      第24回ゆずの木周産期病診連携セミナー
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 先天性サイトロメガロウイルス感染症の周産期管理と医療安全2018

    • Author(s)
      金子政時
    • Organizer
      静岡県産婦人科医会母体保護法指定医師研修会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] TORTCHを知ろう2018

    • Author(s)
      金子政時
    • Organizer
      平成30年度公益社団法人日本助産師会九州・沖縄地区研修会
    • Related Report
      2018 Research-status Report
    • Invited

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Published: 2018-04-23   Modified: 2023-01-30  

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