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Establishment of novel therapeutic strategies based on estrogen-mediated signaling transduction in uterine endometrial cancer

Research Project

Project/Area Number 18K09233
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 56040:Obstetrics and gynecology-related
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

Mori Taisuke  京都府立医科大学, 医学(系)研究科(研究院), 准教授 (00569824)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords子宮体癌 / エストロゲン受容体 / エストロゲン / 受容体
Outline of Final Research Achievements

Compound X, identified as an inhibitory transcriptional effect on ERRα, showed an anti-tumor effect. X also enhanced paclitaxel sensitivity in uterine endometrial cancer cells. ERRα induces TGF-β via cancer-stromal interaction. ERRα also promotes migration and infiltration ability by controlling the expression of EMT-related factors (E-cadherin, Snail, etc.). Taken together, the ERRα-mediated system is promising as a new therapeutic target for endometrial cancer.

Academic Significance and Societal Importance of the Research Achievements

子宮体癌に対してこれまで多くの分子標的薬が試行されてきたが、いずれも満足できる結果は得られていない。近年の網羅的遺伝子解析の結果から(Nature, 2013)、子宮体癌は単一の強い癌遺伝子変異では癌化しにくいことが示されており、腫瘍の生物学的特性に基づいた治療戦略が求められている。子宮体癌の腫瘍学的特徴はホルモン依存性であり、その増殖や発癌にエストロゲンやプロゲステロンが深く関与する。本研究は新規エストロゲン受容体であるエストロゲン関連受容体(ERRα)に着目し、ERRαが子宮体癌における浸潤・進展に関与しており治療ターゲットとして有望であることを示した。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (6 results)

All 2020 2019

All Journal Article (6 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 6 results,  Open Access: 3 results)

  • [Journal Article] Telediagnosis system for congenital heart disease in a Japanese prefecture.2020

    • Author(s)
      Mabuchi A, Waratani M, Tanaka Y, Mori T, Kitawaki J. Telediagnosis system for congenital heart disease in a Japanese prefecture.
    • Journal Title

      J Med Ultrason

      Volume: 47 Issue: 3 Pages: 463-468

    • DOI

      10.1007/s10396-020-01020-y

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prenatal diagnosis of fetal skeletal dysplasia using 3-dimensional computed tomography: a prospective study.2020

    • Author(s)
      Waratani M, Ito F, Tanaka Y, Mabuchi A, Mori T, Kitawaki J.
    • Journal Title

      BMC Musculosketel Disord

      Volume: 21 Issue: 1 Pages: 662-662

    • DOI

      10.1186/s12891-020-03663-x

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protocol for a modified vaginal pipe for total laparoscopic hysterectomies: Experimental research.2020

    • Author(s)
      Ito F, Kokabu T, Matsushima H, Koshiba A, Mori T, Kusuki I, Kitawaki J.
    • Journal Title

      International Journal of Surgery Protocols

      Volume: 21 Issue: 0 Pages: 5-7

    • DOI

      10.1016/j.isjp.2020.02.003

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Unexpected tumor-to-tumor metastasis of synovial sarcoma within leiomyoma: A case report and literature review.2020

    • Author(s)
      Sakai S, Morinaga Y, Koshiba A, Mori T, Kusuki I, Kitawaki J.
    • Journal Title

      J Obstet Gynaecol Res

      Volume: 46 Issue: 7 Pages: 1216-1223

    • DOI

      10.1111/jog.14298

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antitumor effect of XCT790, an ERRα inverse agonist, on ERα-negative endometrial cancer cells.2019

    • Author(s)
      Kokabu T, Mori T, Matsushima H, Yoriki K, Kataoka H, Tarumi Y, Kitawaki J.
    • Journal Title

      Celler Oncology

      Volume: 42(2) Issue: 2 Pages: 223-235

    • DOI

      10.1007/s13402-019-00423-5

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Estrogen-related receptor alpha induces epithelial-mesenchymal transition through cancer-stromal interactions in endometrial cancer.2019

    • Author(s)
      Yoriki K, Mori T, Kokabu T, Matsushima H, Umemura S, Tarumi Y, Kitawaki J
    • Journal Title

      Scientific Reports

      Volume: 9(1) Issue: 1 Pages: 6697-6697

    • DOI

      10.1038/s41598-019-43261-z

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access

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Published: 2018-04-23   Modified: 2022-01-27  

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