Development of decreasing oxidative stress in the ovary to rescue age-related fertility decline

• Project/Area Number: 18K09248
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56040:Obstetrics and gynecology-related
• Research Institution: The University of Tokyo
• Principal Investigator: Hiraike Osamu 東京大学, 医学部附属病院, 准教授 (20529060)
• Co-Investigator(Kenkyū-buntansha): 植田 茉来 (平野茉来) 東京大学, 医学部附属病院, 助教 (80771253) ; 浦田 陽子 東京大学, 医学部附属病院, 助教 (20572598)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 卵巣 / 酸化ストレス / 老化 / 卵巣機能温存

Outline of Final Research Achievements

Based on the findings that the transcription factor Nrf2/Keap1 and p53/Mdm2 pathways are involved in the oxidative stress pathway in the ovary, low molecular weight compounds that act directly on these pathways are considered as a possible candidates for quenching ovarian aging in this study. The effects on the phenotypical changes and the decrease in the number of eggs were clarified by experiments using mice in addition to the primary culture system of human ovarian granulosa cells. After administration of dimethylfumarate, which enhances Nrf2 function, pathological changes in the ovaries were observed. DMF-administered mice showed that the number of eggs were preserved, the anti-Mullerian hormone level was higher than that of the control group, and oxidative stress markers were increased compared to the control group.

Academic Significance and Societal Importance of the Research Achievements

本研究によりラットを用いた実験系においてNrf2の病態生理を追求することが出来た。Nrf2機能を促進することが実際に生体においても抗酸化メカニズムを持つことが示せたことは、分子細胞生物学的理解を深める上で大きい。今回得られた知見は、ヒトへの臨床応用をする上で大前提となるものであり、DMFが酸化ストレス蓄積を改善するための一つの治療選択肢となりうる。DMFが近年の晩婚化の影響で初婚年齢、初回出産年齢が遅れる傾向にある日本人女性における新たな治療選択肢となり得ることを提案することが本課題に課せられた今後の検討課題であろう。

Research Products

• [Journal Article] Use of selective PGE2 receptor antagonists on human endometriotic stromal cells and peritoneal macrophages (2021)
  • Author(s): Makabe Tomoko、Koga Kaori、Nagabukuro Hiroshi、Asada Mari、Satake Erina、Taguchi Ayumi、Takeuchi Arisa、Miyashita Mariko、Harada Miyuki、Hirata Tetsuya、Hirota Yasushi、Wada-Hiraike Osamu、Fujii Tomoyuki、Osuga Yutaka
  • Journal Title: Molecular Human Reproduction Volume: 27 Issue: 1 Pages: 234-234
  • DOI: 10.1093/molehr/gaaa077
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Induction of aryl hydrocarbon receptor in granulosa cells by endoplasmic reticulum stress contributes to pathology of polycystic ovary syndrome (2021)
  • Author(s): Kunitomi C, Harada M, Kusamoto A, Azhary JM, Nose E, Koike H, Xu Z, Urata Y, Takahashi N, Wada-Hiraike O, Hirota Y, Koga K, Fujii T, Osuga Y.
  • Journal Title: Mol Hum Reprod. Volume: 27 Issue: 3 Pages: 234-234
  • DOI: 10.1093/molehr/gaab003
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Epigenetic Modifier SETD8 as a Therapeutic Target for High-Grade Serous Ovarian Cancer (2020)
  • Author(s): Wada Miku、Kukita Asako、Sone Kenbun、Hamamoto Ryuji、Kaneko Syuzo、Komatsu Masaaki、Takahashi Yu、Inoue Futaba、Kojima Machiko、Honjoh Harunori、Taguchi Ayumi、Kashiyama Tomoko、Miyamoto Yuichiro、Tanikawa Michihiro、Tsuruga Tetsushi、Mori-Uchino Mayuyo、Wada-Hiraike Osamu、Osuga Yutaka、Fujii Tomoyuki
  • Journal Title: Biomolecules Volume: 10 Issue: 12 Pages: 1686-1686
  • DOI: 10.3390/biom10121686
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The histone methyltransferase SMYD2 is a novel therapeutic target for the induction of apoptosis in ovarian clear cell carcinoma cells (2020)
  • Author(s): Kojima Machiko、Sone Kenbun、Oda Katsutoshi、Hamamoto Ryuji、Kaneko Syuzo、Oki Shinya、Kukita Asako、Kawata Akira、Honjoh Harunori、Kawata Yoshiko、Kashiyama Tomoko、Sato Masakazu、Taguchi Ayumi、Miyamoto Yuichiro、Tanikawa Michihiro、Tsuruga Tetsushi、Nagasaka Kazunori、Wada?Hiraike Osamu、Osuga Yutaka、Fujii Tomoyuki
  • Journal Title: Oncology Letters Volume: 20 Issue: 5 Pages: 1-1
  • DOI: 10.3892/ol.2020.12014
  • Peer Reviewed / Open Access
• [Journal Article] Effect of murine double‐minute 2 inhibitors in preclinical models of advanced clear cell carcinomas originating from ovaries and kidneys (2020)
  • Author(s): Kawata Yoshiko、Nagasaka Kazunori、Oda Katsutoshi、Makii Chinami、Takeuchi Makoto、Oki Shinya、Honjo Harunori、Kojima Machiko、Miyagawa Yuko、Taguchi Ayumi、Tanikawa Michihiro、Sone Kenbun、Hiraike Haruko、Matsumoto Yoko、Wada‐Hiraike Osamu、Ayabe Takuya、Osuga Yutaka、Fujii Tomoyuki
  • Journal Title: Cancer Science Volume: 111 Issue: 10 Pages: 3824-3834
  • DOI: 10.1111/cas.14583
  • Peer Reviewed / Open Access
• [Journal Article] IFITM1 is a Novel, Highly Sensitive Marker for Endometriotic Stromal Cells in Ovarian and Extragenital Endometriosis (2020)
  • Author(s): Sun Hui、Fukuda Shinya、Hirata Tetsuya、Arakawa Tomoko、Ma Suke、Neriishi Kazuaki、Wang Yu、Takeuchi Arisa、Saeki Ai、Harada Miyuki、Hirota Yasushi、Matsumoto Takashi、Koga Kaori、Wada-Hiraike Osamu、Kurihara Masatoshi、Fujii Tomoyuki、Osuga Yutaka
  • Journal Title: Reproductive Sciences Volume: 27 Issue: 8 Pages: 1595-1601
  • DOI: 10.1007/s43032-020-00189-4
  • Peer Reviewed
• [Journal Article] The effects of tokishakuyakusan, a traditional Japanese medicine (kampo), ferulic acid and paeoniflorin, on human endometriotic stromal cells and peritoneal macrophages (2020)
  • Author(s): Takeuchi Arisa、Koga Kaori、Tokita Yohei、Matsumoto Takashi、Satake Erina、Taguchi Ayumi、Makabe Tomoko、Miyashita Mariko、Takamura Masashi、Harada Miyuki、Hirata Tetsuya、Hirota Yasushi、Wada-Hiraike Osamu、Fujii Tomoyuki、Osuga Yutaka
  • Journal Title: J Reprod Immunol Volume: 139 Pages: 103104-103104
  • DOI: 10.1016/j.jri.2020.103104
  • Peer Reviewed
• [Journal Article] Rikkunshito attenuates induction of epithelial-mesenchymal switch <i>via</i> activation of Sirtuin1 in ovarian cancer cells (2020)
  • Author(s): Kanda Ranka、Miyagawa Yuko、Wada-Hiraike Osamu、Hiraike Haruko、Fukui Shiho、Nagasaka Kazunori、Ryo Eiji、Fujii Tomoyuki、Osuga Yutaka、Ayabe Takuya
  • Journal Title: Endocrine Journal Volume: 67 Issue: 4 Pages: 379-386
  • DOI: 10.1507/endocrj.EJ19-0368
  • NAID: 130007837032
  • ISSN: 0918-8959, 1348-4540
  • Peer Reviewed
• [Journal Article] Chapter 7 - Nrf2 and oxidative stress (2020)
  • Author(s): Wada-Hiraike O
  • Journal Title: Pathology Volume: 1 Pages: 77-86
  • DOI: 10.1016/b978-0-12-815972-9.00007-x
  • ISBN: 9780128159729
  • Peer Reviewed
• [Journal Article] Expression of ALDH1A Isozymes in Human Endometrium with and without Endometriosis and in Ovarian Endometrioma (2020)
  • Author(s): Ma Suke、Hirata Tetsuya、Arakawa Tomoko、Sun Hui、Neriishi Kazuaki、Fukuda Shinya、Nakazawa Akari、Wang Yu、Harada Miyuki、Hirota Yasushi、Koga Kaori、Wada-Hiraike Osamu、Fujii Tomoyuki、Osuga Yutaka
  • Journal Title: Reproductive Sciences Volume: 27 Issue: 1 Pages: 443-452
  • DOI: 10.1007/s43032-019-00041-4
  • Peer Reviewed
• [Journal Article] Real prevalence of neural tube defects in Japan: How many of such pregnancies have been terminated? (2019)
  • Author(s): Kondo Atsuoi、Wada‐HIraike Osamu、Watanabe Tomoyuki、Yamaguchi Masatoshi、Yasui Tomoyo、Yokomine Masato
  • Journal Title: Congenital Anomalies Volume: 59 Issue: 4 Pages: 118-124
  • DOI: 10.1111/cga.12333
• [Journal Article] Histone methyltransferase SMYD2 selective inhibitor LLY-507 in combination with poly ADP ribose polymerase inhibitor has therapeutic potential against high-grade serous ovarian carcinomas. (2019)
  • Author(s): Kukita A, Sone K, Oda K, Hamamoto R, Kaneko S, Komatsu M, Wada M, Honjoh H, Kawata Y, Kojima M, Oki S, Sato M, Asada K, Taguchi A, Miyasaka A, Tanikawa M, Nagasaka K, Matsumoto Y, Wada-Hiraike O, Osuga Y, Fujii T
  • Journal Title: Biochem Biophys Res Commun Volume: in press Issue: 2 Pages: 30555-8
  • DOI: 10.1016/j.bbrc.2019.03.155
  • Peer Reviewed
• [Journal Article] A case of functioning gonadotroph adenoma in a reproductive aged woman (2019)
  • Author(s): Hirano Mana、Wada-Hiraike Osamu、Miyamamoto Yuichiro、Yamada Shozo、Fujii Tomoyuki、Osuga Yutaka
  • Journal Title: Endocrine Journal Volume: 66 Issue: 7 Pages: 653-656
  • DOI: 10.1507/endocrj.EJ19-0066
  • NAID: 130007684325
  • ISSN: 0918-8959, 1348-4540
• [Journal Article] Contralateral ovarian endometrioma recurrence after unilateral salpingo-oophorectomy (2019)
  • Author(s): Hidari Tokie、Hirata Tetsuya、Arakawa Tomoko、Koga Kaori、Neriishi Kazuaki、Fukuda Shinya、Nakazawa Akari、Nagashima Natsuki、Ma Suke、Sun Hui、Takamura Masashi、Harada Miyuki、Hirota Yasushi、Wada-Hiraike Osamu、Fujii Tomoyuki、Osuga Yutaka
  • Journal Title: BMC Women's Health Volume: 19 Issue: 1 Pages: 59-59
  • DOI: 10.1186/s12905-019-0760-z
  • Peer Reviewed / Open Access
• [Journal Article] The histone methyltransferase WHSC1 is regulated by EZH2 and is important for ovarian clear cell carcinoma cell proliferation (2019)
  • Author(s): Kojima Machiko、Sone Kenbun、Wada-Hiraike Osamu、Osuga Yutaka、Fujii Tomoyuki
  • Journal Title: BMC Cancer Volume: 19 Issue: 1 Pages: 455-455
  • DOI: 10.1186/s12885-019-5638-9
  • Peer Reviewed / Open Access
• [Journal Article] Endometriosis Triggers Excessive Activation of Primordial Follicles via PI3K-PTEN-Akt-Foxo3 Pathway (2019)
  • Author(s): Takeuchi Arisa、Koga Kaori、Satake Erina、Makabe Tomoko、Taguchi Ayumi、Miyashita Mariko、Takamura Masashi、Harada Miyuki、Hirata Tetsuya、Hirota Yasushi、Yoshino Osamu、Wada-Hiraike Osamu、Fujii Tomoyuki、Osuga Yutaka
  • Journal Title: The Journal of Clinical Endocrinology & Metabolism Volume: 104 Issue: 11 Pages: 5547-5554
  • DOI: 10.1210/jc.2019-00281
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Role of oxidative stress in follicular fluid on embryos of patients undergoing assisted reproductive technology treatment (2019)
  • Author(s): Terao Hiromi、Wada‐Hiraike Osamu、Nagumo Aiko、Kunitomi Chisato、Azhary Jerilee M. K.、Harada Miyuki、Hirata Tetsuya、Hirota Yasushi、Koga Kaori、Fujii Tomoyuki、Osuga Yutaka
  • Journal Title: Journal of Obstetrics and Gynaecology Research Volume: 45 Issue: 9 Pages: 1884-1891
  • DOI: 10.1111/jog.14040
  • Peer Reviewed
• [Journal Article] Clinical aspects and management of inguinal endometriosis: A case series of 20 patients (2019)
  • Author(s): Arakawa Tomoko、Hirata Tetsuya、Koga Kaori、Neriishi Kazuaki、Fukuda Shinya、Ma Suke、Sun Hui、Nagashima Natsuki、Harada Miyuki、Hirota Yasushi、Wada‐Hiraike Osamu、Fujii Tomoyuki、Osuga Yutaka
  • Journal Title: Journal of Obstetrics and Gynaecology Research Volume: 45 Issue: 10 Pages: 2029-2036
  • DOI: 10.1111/jog.14059
  • Peer Reviewed
• [Journal Article] On-chip immunofluorescence analysis of single cervical cells using an electroactive microwell array with barrier for cervical screening (2019)
  • Author(s): Takeuchi Makoto、Nagasaka Kazunori、Yoshida Mina、Kawata Yoshiko、Miyagawa Yuko、Tago Saori、Hiraike Haruko、Wada-Hiraike Osamu、Oda Katsutoshi、Osuga Yutaka、Fujii Tomoyuki、Ayabe Takuya、Kim Soo Hyeon、Fujii Teruo
  • Journal Title: Biomicrofluidics Volume: 13 Issue: 4 Pages: 044107-044107
  • DOI: 10.1063/1.5089796
  • Peer Reviewed
• [Journal Article] Anti-tumor activity of dual inhibition of phosphatidylinositol 3-kinase and MDM2 against clear cell ovarian carcinoma (2019)
  • Author(s): Makii Chinami、Ikeda Yuji、Oda Katsutoshi、Wada-Hiraike Osamu、Kawana Kei、Hasegawa Kosei、Fujiwara Keiichi、Aburatani Hiroyuki、Osuga Yutaka、Fujii Tomoyuki
  • Journal Title: Gynecologic Oncology Volume: 155 Issue: 2 Pages: 331-339
  • DOI: 10.1016/j.ygyno.2019.08.028
  • Peer Reviewed
• [Journal Article] Accumulation of advanced glycation end products in follicles is associated with poor oocyte developmental competence (2019)
  • Author(s): Takahashi Nozomi、Harada Miyuki、Azhary Jerilee M K、Kunitomi Chisato、Nose Emi、Terao Hiromi、Koike Hiroshi、Wada-Hiraike Osamu、Hirata Tetsuya、Hirota Yasushi、Koga Kaori、Fujii Tomoyuki、Osuga Yutaka
  • Journal Title: Molecular Human Reproduction Volume: 25 Issue: 11 Pages: 684-694
  • DOI: 10.1093/molehr/gaz050
  • Peer Reviewed / Open Access
• [Journal Article] A survey of public attitudes toward uterus transplantation, surrogacy, and adoption in Japan (2019)
  • Author(s): Nakazawa Akari、Hirata Tetsuya、Arakawa Tomoko、Nagashima Natsuki、Fukuda Shinya、Neriishi Kazuaki、Harada Miyuki、Hirota Yasushi、Koga Kaori、Wada-Hiraike Osamu、Koizumi Yoshio、Fujii Tomoyuki、Irahara Minoru、Osuga Yutaka
  • Journal Title: PLOS ONE Volume: 14 Issue: 10 Pages: 0223571-0223571
  • DOI: 10.1371/journal.pone.0223571
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The proteasome deubiquitinase inhibitor bAP15 downregulates TGF-β/Smad signaling and induces apoptosis via UCHL5 inhibition in ovarian cancer. (2019)
  • Author(s): Fukui S, Nagasaka K, Miyagawa Y, Kikuchi-Koike R, Kawata Y, Kanda R, Ichinose T, Sugihara T, Hiraike H, Wada-Hiraike O, Sasajima Y, Ayabe T
  • Journal Title: Oncotarget Volume: 10 Issue: 57 Pages: 5932-5948
  • DOI: 10.18632/oncotarget.27219
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Anti-Tumor Effect of Inhibition of DNA Damage Response Proteins, ATM and ATR, in Endometrial Cancer Cells (2019)
  • Author(s): Takeuchi Makoto、Tanikawa Michihiro、Nagasaka Kazunori、Oda Katsutoshi、Kawata Yoshiko、Oki Shinya、Agapiti Chuwa、Sone Kenbun、Miyagawa Yuko、Hiraike Haruko、Wada-Hiraike Osamu、Kuramoto Hiroyuki、Ayabe Takuya、Osuga Yutaka、Fujii Tomoyuki
  • Journal Title: Cancers Volume: 11 Issue: 12 Pages: 1913-1913
  • DOI: 10.3390/cancers11121913
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Activation of endoplasmic reticulum stress mediates oxidative stress?induced apoptosis of granulosa cells in ovaries affected by endometrioma (2019)
  • Author(s): Kunitomi Chisato、Harada Miyuki、Takahashi Nozomi、Azhary Jerilee M K、Kusamoto Akari、Nose Emi、Oi Nagisa、Takeuchi Arisa、Wada-Hiraike Osamu、Hirata Tetsuya、Hirota Yasushi、Koga Kaori、Fujii Tomoyuki、Osuga Yutaka
  • Journal Title: Molecular Human Reproduction Volume: 26 Issue: 1 Pages: 40-52
  • DOI: 10.1093/molehr/gaz066
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Activation of Nrf2/Keap1 pathway by oral Dimethylfumarate administration alleviates oxidative stress and age-associated infertility might be delayed in the mouse ovary (2019)
  • Author(s): Akino Nana、Wada-Hiraike Osamu、Isono Wataru、Terao Hiromi、Honjo Harunori、Miyamoto Yuichiro、Tanikawa Michihiro、Sone Kenbun、Hirano Mana、Harada Miyuki、Hirata Tetsuya、Hirota Yasushi、Koga Kaori、Oda Katsutoshi、Fujii Tomoyuki、Osuga Yutaka
  • Journal Title: Reproductive Biology and Endocrinology Volume: 17 Issue: 1 Pages: 2323-2323
  • DOI: 10.1186/s12958-019-0466-y
  • Peer Reviewed / Open Access
• [Journal Article] Guideline for cryopreservation of unfertilized eggs and ovarian tissues in Japan Society of Reproductive Medicine (2018)
  • Author(s): Harada Tasuku、Kuji Naoaki、Ishihara Osamu、Ichikawa Tomohiko、Irahara Minoru、Katagiri Yukiko、Saito Hidekazu、Harada Tatsuya、Wada-Hiraike Osamu、Taniguchi Fuminori、Ethics Committee in Japan Society of Reproductive Medicine
  • Journal Title: Reproductive Medicine and Biology Volume: 18 Issue: 1 Pages: 3-6
  • DOI: 10.1002/rmb2.12236
• [Journal Article] Endoplasmic Reticulum Stress Activated by Androgen Enhances Apoptosis of Granulosa Cells via Induction of Death Receptor 5 in PCOS (2018)
  • Author(s): Azhary Jerilee M K、Harada Miyuki、Takahashi Nozomi、Nose Emi、Kunitomi Chisato、Koike Hiroshi、Hirata Tetsuya、Hirota Yasushi、Koga Kaori、Wada-Hiraike Osamu、Fujii Tomoyuki、Osuga Yutaka
  • Journal Title: Endocrinology Volume: 160 Issue: 1 Pages: 119-132
  • DOI: 10.1210/en.2018-00675
  • Peer Reviewed / Open Access
• [Journal Article] A survey of public attitudes towards third-party reproduction in Japan in 2014 (2018)
  • Author(s): Yamamoto Naoko、Hirata Tetsuya、Izumi Gentaro、Nakazawa Akari、Fukuda Shinya、Neriishi Kazuaki、Arakawa Tomoko、Takamura Masashi、Harada Miyuki、Hirota Yasushi、Koga Kaori、Wada-Hiraike Osamu、Fujii Tomoyuki、Irahara Minoru、Osuga Yutaka
  • Journal Title: PLOS ONE Volume: 13 Issue: 10 Pages: 198499-198499
  • DOI: 10.1371/journal.pone.0198499
  • Peer Reviewed / Open Access
• [Journal Article] Prediction of the operative time for hysteroscopic myomectomy for leiomyomas penetrating the intramural cavity using leiomyoma weight and clinical characteristics of patients (2018)
  • Author(s): Isono Wataru、Wada-Hiraike Osamu、Sugiyama Ryo、Maruyama Masanori、Fujii Tomoyuki、Osuga Yutaka
  • Journal Title: Reproductive Medicine and Biology Volume: 17 Issue: 4 Pages: 487-492
  • DOI: 10.1002/rmb2.12228
• [Journal Article] Kaempferol, a natural dietary flavonoid, suppresses 17β?estradiol?induced survivin expression and causes apoptotic cell death in endometrial cancer (2018)
  • Author(s): Chuwa Agapiti、Sone Kenbun、Oda Katsutoshi、Tanikawa Michihiro、Kukita Asako、Kojima Machiko、Oki Shinya、Fukuda Tomohiko、Takeuchi Makoto、Miyasaka Aki、Kashiyama Tomoko、Ikeda Yuji、Nagasaka Kazunori、Mori?Uchino Mayuyo、Matsumoto Yoko、Wada?Hiraike Osamu、Kuramoto Hiroyuki、Kawana Kei、Osuga Yutaka、Fujii Tomoyuki
  • Journal Title: Oncology Letters Volume: 16 Pages: 6195-6201
  • DOI: 10.3892/ol.2018.9340
  • Peer Reviewed / Open Access
• [Journal Article] Expression of Nerve Injury-Induced Protein1 (Ninj1) in Endometriosis (2018)
  • Author(s): Miyashita Mariko、Koga Kaori、Takeuchi Arisa、Makabe Tomoko、Taguchi Ayumi、Urata Yoko、Izumi Gentaro、Takamura Masashi、Harada Miyuki、Hirata Tetsuya、Hirota Yasushi、Wada-Hiraike Osamu、Yoshino Osamu、Fujii Tomoyuki、Osuga Yutaka
  • Journal Title: Reproductive Sciences Volume: in press Issue: 8 Pages: 368-375
  • DOI: 10.1177/1933719118806395
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The efficacy of non-assisted reproductive technology treatment might be limited in infertile patients with advanced endometriosis in their 30s (2018)
  • Author(s): Isono Wataru、Wada-Hiraike Osamu、Akino Nana、Terao Hiromi、Harada Miyuki、Hirata Tetsuya、Hirota Yasushi、Koga Kaori、Fujii Tomoyuki、Osuga Yutaka
  • Journal Title: Journal of Obstetrics and Gynaecology Research Volume: 45 Issue: 2 Pages: 368-375
  • DOI: 10.1111/jog.13826
  • Peer Reviewed
• [Journal Article] A nationwide survey on gynecologic endoscopic surgery in Japan, 2014-2016 (2018)
  • Author(s): Taniguchi Fuminori、Wada-Hiraike Osamu、Hirata Tetsuya、Tajima Hiroto、Masuda Hirotaka、Kitade Mari、Kumakiri Jun、Uchiide Ichiro、Saito Juichiro、Kurose Keisuke、Takeshita Toshiyuki、Harada Tasuku
  • Journal Title: Journal of Obstetrics and Gynaecology Research Volume: 44 Issue: 11 Pages: 2067-2076
  • DOI: 10.1111/jog.13774
• [Journal Article] Factors associated with successful pregnancy in women of late reproductive age with uterine fibroids who undergo embryo cryopreservation before surgery (2018)
  • Author(s): Takahashi Nozomi、Harada Miyuki、Tanabe Ryosuke、Takayanagi Akane、Izumi Gentaro、Oi Nagisa、Hirata Tetsuya、Wada-Hiraike Osamu、Fujii Tomoyuki、Osuga Yutaka
  • Journal Title: Journal of Obstetrics and Gynaecology Research Volume: 44 Issue: 10 Pages: 1439-1444
  • DOI: 10.1111/jog.13754
• [Journal Article] Expression of the glucagon-like peptide-1 receptor and its role in regulating autophagy in endometrial cancer (2018)
  • Author(s): Kanda Ranka、Hiraike Haruko、Wada-Hiraike Osamu、Ichinose Takayuki、Nagasaka Kazunori、Sasajima Yuko、Ryo Eiji、Fujii Tomoyuki、Osuga Yutaka、Ayabe Takuya
  • Journal Title: BMC Cancer Volume: 18 Issue: 1 Pages: 657-657
  • DOI: 10.1186/s12885-018-4570-8
• [Journal Article] Long-term dienogest administration in patients with symptomatic adenomyosis (2018)
  • Author(s): Neriishi Kazuaki、Hirata Tetsuya、Fukuda Shinya、Izumi Gentaro、Nakazawa Akari、Yamamoto Naoko、Harada Miyuki、Hirota Yaushi、Koga Kaori、Wada-Hiraike Osamu、Fujii Tomoyuki、Osuga Yutaka
  • Journal Title: Journal of Obstetrics and Gynaecology Research Volume: 44 Issue: 8 Pages: 1439-1444
  • DOI: 10.1111/jog.13674
  • Peer Reviewed
• [Journal Article] Thoracic endometriosis syndrome: Comparison between catamenial pneumothorax or endometriosis-related pneumothorax and catamenial hemoptysis (2018)
  • Author(s): Fukuda Shinya、Hirata Tetsuya、Neriishi Kazuaki、Nakazawa Akari、Takamura Masashi、Izumi Gentaro、Harada Miyuki、Hirota Yasushi、Koga Kaori、Wada-Hiraike Osamu、Fujii Tomoyuki、Osuga Yutaka
  • Journal Title: European Journal of Obstetrics & Gynecology and Reproductive Biology Volume: 225 Pages: 118-123
  • DOI: 10.1016/j.ejogrb.2018.04.021
  • Peer Reviewed
• [Journal Article] Activation of Nrf2 might reduce oxidative stress in human granulosa cells (2018)
  • Author(s): Akino Nana、Wada-Hiraike Osamu、Terao Hiromi、Honjoh Harunori、Isono Wataru、Fu Houju、Hirano Mana、Miyamoto Yuichiro、Tanikawa Michihiro、Harada Miyuki、Hirata Tetsuya、Hirota Yasushi、Koga Kaori、Oda Katsutoshi、Kawana Kei、Fujii Tomoyuki、Osuga Yutaka
  • Journal Title: Mol Cell Endocrinol Volume: 印刷中 Pages: 1-9
  • DOI: 10.1016/j.mce.2017.10.002
  • Peer Reviewed / Open Access
• [Journal Article] Administration of Oral Contraceptives Could Alleviate Age-Related Fertility Decline Possibly by Preventing Ovarian Damage in a Mouse Model (2017)
  • Author(s): Isono Wataru、Wada-Hiraike Osamu、Kawamura Yumiko、Fujii Tomoyuki、Osuga Yutaka、Kurihara Hiroki
  • Journal Title: Reproductive Sciences Volume: - Issue: 9 Pages: 1413-1423
  • DOI: 10.1177/1933719117746758
  • Peer Reviewed
• [Presentation] 月経困難症・子宮内膜症治療手段としてのLEP使用方法 Update (2021)
  • Author(s): 平池修
  • Organizer: 第42回日本エンドメトリオーシス学会
  • Invited
• [Presentation] 周閉経期女性の不眠症とその治療 (2021)
  • Author(s): 平池修
  • Organizer: 第14回日本性差医学・医療学会
  • Invited
• [Presentation] Dual Ovarian Stimulation法（DuoStim法）の概念と実際 (2020)
  • Author(s): 平池修
  • Organizer: 第72回日本産科婦人科学会
  • Invited
• [Presentation] 卵巣における酸化ストレスメカニズムの役割と治療的展望 (2020)
  • Author(s): 平池修
  • Organizer: 第93回日本内分泌学会 学術講演会・総会
  • Invited
• [Presentation] 骨盤臓器脱手術 最近のトレンドと安全担保 (2020)
  • Author(s): 平池修
  • Organizer: 第139回関東連合産科婦人科学会
  • Invited
• [Presentation] 子宮内膜症のもたらす全身的影響と治療がもたらすベネフィット (2020)
  • Author(s): 平池修
  • Organizer: 第142回近畿産科婦人科学会学術集会
  • Invited
• [Presentation] 女性の身体とエストロゲン～皮膚～ (2020)
  • Author(s): 平池修
  • Organizer: 第35回日本女性医学学会
  • Invited
• [Presentation] 第15回技術認定審査コンセンサスミーティング（腹腔鏡） (2020)
  • Author(s): 平池修
  • Organizer: 第60回日本産科婦人科内視鏡学会
  • Invited
• [Presentation] 骨盤臓器脱手術の低侵襲化とロボット支援下手術RSCの将来的展望 (2020)
  • Author(s): 平池修
  • Organizer: 第60回日本産科婦人科内視鏡学会
  • Invited
• [Presentation] 不妊症における子宮筋腫の取り扱い (2020)
  • Author(s): 平池修
  • Organizer: 第65回日本生殖医学学会講演会
  • Invited
• [Presentation] 女性のヘルスケアと慢性便秘症 (2020)
  • Author(s): 平池 修
  • Organizer: 岩手産科婦人科集談会
  • Invited
• [Presentation] 子宮筋腫の薬物治療開発歴史と今後の展望 (2020)
  • Author(s): 平池 修
  • Organizer: 第41回エンドメトリオーシス学会
  • Invited
• [Presentation] 子宮内膜症と周産期トラブルとの関連について (2019)
  • Author(s): 平池 修
  • Organizer: 南多摩産婦人科医会
  • Invited
• [Presentation] 子宮内膜症に関連する周産期合併症 (2019)
  • Author(s): 平池 修
  • Organizer: 第71回日本産科婦人科学会
  • Invited
• [Presentation] 子宮筋腫の薬物療法の新展開 (2019)
  • Author(s): 平池 修
  • Organizer: 第287回広島市臨床産婦人科研修会
  • Invited
• [Presentation] OC/LEP投与の新機軸～連続投与という選択肢～ (2019)
  • Author(s): 平池 修
  • Organizer: 尼崎産婦人科医会学術講演会
  • Invited
• [Presentation] 女性の健康包括的支援におけるLEP製剤連続投与の役割 (2019)
  • Author(s): 平池 修
  • Organizer: 静岡産科婦人科学会春季学術集会
  • Invited
• [Presentation] 子宮内膜症がもたらす様々なリスクと早期介入の重要性 (2019)
  • Author(s): 平池 修
  • Organizer: 2019年度女性医療セミナー
  • Invited
• [Presentation] 子宮内膜症克服への新たな課題：子宮内膜症と産科合併症との関連 (2019)
  • Author(s): 平池 修
  • Organizer: 渋谷区産婦人科医会
  • Invited
• [Presentation] 慢性便秘症の新展開と女性診療 (2019)
  • Author(s): 平池 修
  • Organizer: 石川県産婦人科学術講演会
  • Invited
• [Presentation] 子宮内膜症に関連する周産期合併症 (2019)
  • Author(s): 平池 修
  • Organizer: 宇都宮産婦人科医会
  • Invited
• [Presentation] 子宮内膜症カスケードを解決するためのLEP製剤連続投与の位置づけ (2019)
  • Author(s): 平池 修
  • Organizer: 新潟市産婦人科医会学術講演会
  • Invited
• [Presentation] 子宮筋腫の治療とGnRHアンタゴニストの役割 (2019)
  • Author(s): 平池 修
  • Organizer: 茨城県産婦人科医会県南支部学術講演会
  • Invited
• [Presentation] 子宮筋腫治療の新常識：GnRHアンタゴニストについて (2019)
  • Author(s): 平池 修
  • Organizer: 第16回深谷寄居産婦人科医会学術講演会
  • Invited
• [Presentation] 子宮筋腫治療の新常識：GnRHアンタゴニストについて (2019)
  • Author(s): 平池 修
  • Organizer: 愛知県産婦人科医会第6回学術研修会
  • Invited
• [Presentation] 子宮内膜症カスケードと周産期関連疾患 (2019)
  • Author(s): 平池 修
  • Organizer: 京都産科婦人科医会学術講演会
  • Invited
• [Presentation] 腹腔鏡手術の安全担保と癒着の予防 (2019)
  • Author(s): 平池 修
  • Organizer: 第138回関東連合産科婦人科学会
  • Invited
• [Presentation] 女性の下腹部痛マネジメント～月経困難症と消化器症状を含めて～ (2019)
  • Author(s): 平池 修
  • Organizer: 第34回日本女性医学学会学術講演会
  • Invited
• [Presentation] LEP連続投与と女性の健康活躍推進をエビデンスからみる (2019)
  • Author(s): 平池 修
  • Organizer: 第34回日本女性医学学会学術講演会
  • Invited
• [Presentation] Effort of our society JSGOE to promote medical safety on MIGS (2019)
  • Author(s): Osamu Hiraike
  • Organizer: 48th American Association of Gynecological laparoscopy 2019
  • Int'l Joint Research / Invited
• [Presentation] LEP連続投与と女性の健康活躍推進をエビデンスからみる (2019)
  • Author(s): 平池 修
  • Organizer: 山梨県産科婦人科学会・山梨県産婦人科医会合同講演会
  • Invited
• [Presentation] 産婦人科領域におけるGnRHアゴニストおよびアンタゴニストとその将来的展望 (2019)
  • Author(s): 平池 修
  • Organizer: 第40回日本エンドメトリオーシス学会
  • Invited
• [Presentation] 不妊症症例が生児獲得へ至るまでの甲状腺機能マネジメント (2018)
  • Author(s): 平池 修
  • Organizer: 第91回日本内分泌学会
  • Invited
• [Presentation] 子宮内膜症の新たな課題・周産期異常との関連 (2018)
  • Author(s): 平池 修
  • Organizer: 第70回日本産科婦人科学会
  • Invited
• [Presentation] 女性の健康包括的支援に植物エストロゲンが果たす役割 (2018)
  • Author(s): 平池 修
  • Organizer: 第91回日本産業衛生学会
  • Invited
• [Presentation] Introduction of JSGOE and our future perspectives (2018)
  • Author(s): Osamu Hiraike
  • Organizer: ESGE 27th Annual Congress
  • Int'l Joint Research / Invited
• [Presentation] アスリートに対するホルモン療法の実際 (2018)
  • Author(s): 平池 修、能瀬さやか
  • Organizer: 第33回日本女性医学学会
  • Invited