Development of molecular targeted therapies for ovarian cancer with homologous recombination deficiency

• Project/Area Number: 18K09249
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56040:Obstetrics and gynecology-related
• Research Institution: The University of Tokyo
• Principal Investigator: Oda Katsutoshi 東京大学, 医学部附属病院, 教授 (30359608)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 卵巣癌 / 分子標的薬 / ゲノム解析 / 相同組換修復欠損 / ネオアンチゲン / 卵巣高異型度漿液性癌 / 免疫チェックポイント阻害剤 / TP53 / MDM2 / PI3K / DNA修復 / 分子標的治療 / PARP / 相同組換え修復不全 / BRCA1/2 / 変異シグネチャー / 相同組換修復 / PARP阻害剤 / バイオマーカー

Outline of Final Research Achievements

The expression profiles of SMYD2 showed significant overexpression of SMYD2 in high-grade serous ovarian carcinomas (HGSOC). Inhibition of SMYD2 by a SMYD2 inhibitor, LLY-507, increased the number of apoptotic cells and showed additive effect with olaparib inHGSOC cells.
The numbers of predicted neoantigens (neoAgs) were lower in HR-proficient than HR-deficient tumors. However, 40% of the patients with HR-proficient tumors still had higher than median numbers of neoAgs. Patients with both high neoAg numbers and high HLA-class I expression had the best progression-free survival in HR-proficient HGSOC.
In mouse models, MDM2 inhibitor, DS-5272, significantly inhibited ascites production, and significantly improved overall survival. Furthermore, DS-5272 significantly decreased vascular endothelial growth factor concentrations in both sera and ascites. Combined DS-5272 and an mTOR inhibitor, everolimus, showed synergistic anti-tumor effect in clear cell carcinomas.

Academic Significance and Societal Importance of the Research Achievements

卵巣癌におけるゲノム・エピゲノム異常に基づき、治療標的分子を同定し、新たな個別化医療につながる可能性のある知見を報告した。
相同組換修復と関連するような分子標的治療法は他がん種でも注目されており、卵巣高異型度漿液性癌における本研究成果に基づくサブタイプの同定や分子標的治療法の探索が、将来的な卵巣癌のPrecision Medicineの発展に寄与すると期待される。相同組換修復異常と関連する変異シグネチャーとの相関についての知見は、知財申請につなげており、新規の検査法につながることも期待される。

Research Products

• [Journal Article] Automated system for diagnosing endometrial cancer by adopting deep-learning technology in hysteroscopy. (2021)
  • Author(s): Takahashi Y, Sone K, Noda K, Yoshida K, Toyohara Y, Kato K, Inoue F, Kukita A, Taguchi A, Nishida H, Miyamoto Y, Tanikawa M, Tsuruga T, Iriyama T, Nagasaka K, Matsumoto Y, Hirota Y, Hiraike-Wada O, Oda K, Maruyama M, Osuga Y, Fujii T.
  • Journal Title: PLoS One Volume: 16 Issue: 3 Pages: 1-13
  • DOI: 10.1371/journal.pone.0248526
  • Peer Reviewed / Open Access
• [Journal Article] Comprehensive immunohistochemical analysis of the gastrointestinal and M?llerian phenotypes of 139 ovarian mucinous cystadenomas (2021)
  • Author(s): Halimi Sultan Ahmad、Maeda Daichi、Ushiku-Shinozaki Aya、Goto Akiteru、Oda Katsutoshi、Osuga Yutaka、Fujii Tomoyuki、Ushiku Tetsuo、Fukayama Masashi
  • Journal Title: Human Pathology Volume: 109 Pages: 21-30
  • DOI: 10.1016/j.humpath.2020.11.011
  • Peer Reviewed
• [Journal Article] Possible candidate population for neoadjuvant chemotherapy in women with advanced ovarian cancer (2021)
  • Author(s): Matsuo Koji、Matsuzaki Shinya、Nusbaum David J.、Maoz Asaf、Oda Katsutoshi、Klar Maximilian、Roman Lynda D.、Sood Anil K.
  • Journal Title: Gynecologic Oncology Volume: 160 Issue: 1 Pages: 32-39
  • DOI: 10.1016/j.ygyno.2020.10.027
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Genetic Testing Distinguishes Multiple Chondroid Chordomas with Neuraxial Bone Metastases from Multicentric Tumors (2020)
  • Author(s): Kobayashi Hiroshi、Shin Masahiro、Makise Naohiro、Shinozaki-Ushiku Aya、Ikegami Masachika、Taniguchi Yuki、Shinoda Yusuke、Kohsaka Shinji、Ushiku Tetsuo、Oda Katsutoshi、Miyagawa Kiyoshi、Aburatani Hiroyuki、Mano Hiroyuki、Tanaka Sakae
  • Journal Title: Case Reports in Genetics Volume: 2020 Pages: 1-6
  • DOI: 10.1155/2020/8877722
  • Peer Reviewed / Open Access
• [Journal Article] Clinical practice guidance for next-generation sequencing in cancer diagnosis and treatment (edition 2) (2020)
  • Author(s): Naito Y, Aburatani H, Amano T, Baba E, Furukawa T, Hayashida T, Hiyama E, Ikeda S, Kanai M, Kato M, Kinoshita I, Kiyota N, Kohno T, Kohsaka S, et al.
  • Journal Title: Int J Clin Oncol Volume: － Issue: 2 Pages: 233-283
  • DOI: 10.1007/s10147-020-01831-6
  • Peer Reviewed / Open Access
• [Journal Article] Use of Cap Analysis Gene Expression to detect human papillomavirus promoter activity patterns at different disease stages (2020)
  • Author(s): Taguchi A, Nagasaka K, Plessy C, Nakamura H, Kawata Y, Kato S, Hashimoto K, Nagamatsu T, Oda K, Kukimoto I, Kawana K, Carninci P, Osuga Y, Fujii T.
  • Journal Title: Sci Rep Volume: 10 Issue: 1 Pages: 17991-17991
  • DOI: 10.1038/s41598-020-75133-2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The histone methyltransferase SMYD2 is a novel therapeutic target for the induction of apoptosis in ovarian clear cell carcinoma cells (2020)
  • Author(s): Kojima Machiko、Sone Kenbun、Oda Katsutoshi、Hamamoto Ryuji、Kaneko Syuzo、Oki Shinya、Kukita Asako、Kawata Akira、Honjoh Harunori、Kawata Yoshiko、Kashiyama Tomoko、Sato Masakazu、Taguchi Ayumi、Miyamoto Yuichiro、Tanikawa Michihiro、Tsuruga Tetsushi、Nagasaka Kazunori、Wada?Hiraike Osamu、Osuga Yutaka、Fujii Tomoyuki
  • Journal Title: Oncology Letters Volume: 20 Issue: 5 Pages: 1-1
  • DOI: 10.3892/ol.2020.12014
  • Peer Reviewed / Open Access
• [Journal Article] Desensitization strategy for hypersensitivity reactions to carboplatin in five patients with gynecological cancer (2020)
  • Author(s): Toyohara Yusuke、Sone Kenbun、Nishida Haruka、Taguchi Ayumi、Miyamoto Yuichiro、Tanikawa Michihiro、Mori Mayuyo、Tsuruga Tetsushi、Matsumoto Yoko、Oda Katsutoshi、Osuga Yutaka、Fujii Tomoyuki
  • Journal Title: Journal of Obstetrics and Gynaecology Research Volume: 46 Issue: 11 Pages: 2298-2304
  • DOI: 10.1111/jog.14443
  • Peer Reviewed
• [Journal Article] Usefulness of biopsy by office hysteroscopy for endometrial cancer: A case report (2020)
  • Author(s): Sone Kenbun、Eguchi Satoko、Asada Kayo、Inoue Futaba、Miyamoto Yuichiro、Tanikawa Michihiro、Tsuruga Tetsushi、Mori?Uchino Mayuyo、Matsumoto Yoko、Hiraike?Wada Osamu、Oda Katsutoshi、Osuga Yutaka、Fujii Tomoyuki
  • Journal Title: Molecular and Clinical Oncology Volume: 13 Issue: 2 Pages: 141-145
  • DOI: 10.3892/mco.2020.2053
  • Peer Reviewed / Open Access
• [Journal Article] Effect of murine double‐minute 2 inhibitors in preclinical models of advanced clear cell carcinomas originating from ovaries and kidneys (2020)
  • Author(s): Kawata Yoshiko、Nagasaka Kazunori、Oda Katsutoshi、Makii Chinami、Takeuchi Makoto、Oki Shinya、Honjo Harunori、Kojima Machiko、Miyagawa Yuko、Taguchi Ayumi、Tanikawa Michihiro、Sone Kenbun、Hiraike Haruko、Matsumoto Yoko、Wada‐Hiraike Osamu、Ayabe Takuya、Osuga Yutaka、Fujii Tomoyuki
  • Journal Title: Cancer Science Volume: 111 Issue: 10 Pages: 3824-3834
  • DOI: 10.1111/cas.14583
  • Peer Reviewed / Open Access
• [Journal Article] Genomic Profiling of Multiple Primary Cancers Including Synchronous Lung Adenocarcinoma and Bilateral Malignant Mesotheliomas: Identification of a Novel BAP1 Germline Variant (2020)
  • Author(s): Shinozaki-Ushiku A, Kohsaka S, Kage H, Oda K, Miyagawa K, Nakajima J, Aburatani H, Mano H, Ushiku T
  • Journal Title: Pathology International Volume: － Issue: 10 Pages: 775-780
  • DOI: 10.1111/pin.12977
  • Peer Reviewed
• [Journal Article] Neoantigen load and HLA-class I expression identify a subgroup of tumors with a T-cell-inflamed phenotype and favorable prognosis in homologous recombination-proficient high-grade serous ovarian carcinoma (2020)
  • Author(s): Matsushita Hirokazu、Hasegawa Kosei、Oda Katsutoshi、Yamamoto Shogo、Asada Kayo、Karasaki Takahiro、Yabuno Akira、Nishijima Akira、Nejo Takahide、Kobayashi Yukari、Sato Sho、Ikeda Yuji、Miyai Manami、Takahashi Yusuke、Yamaguchi Rui、Fujiwara Keiichi、Aburatani Hiroyuki、Kakimi Kazuhiro
  • Journal Title: Journal for ImmunoTherapy of Cancer Volume: 8 Issue: 1 Pages: e000375-e000375
  • DOI: 10.1136/jitc-2019-000375
  • Peer Reviewed / Open Access
• [Journal Article] Spinal solitary fibrous tumor of the neck: Next-generation sequencing-based analysis of genomic aberrations. (2020)
  • Author(s): Ando M, Kobayashi H, Shinozaki-Ushiku A, Chikuda H, Matsubayashi Y, Yoshida M, Saito Y, Kohsaka S, Oda K, Miyagawa K, Aburatani H, Mano H, Yamasoba T.
  • Journal Title: Auris Nasus Larynx. Volume: Epub ahead of print Issue: 6 Pages: 1058-1063
  • DOI: 10.1016/j.anl.2019.12.001
  • Peer Reviewed
• [Journal Article] Multistate Markov Model to Predict the Prognosis of High-Risk Human Papillomavirus-Related Cervical Lesions. (2020)
  • Author(s): Taguchi A, Hara K, Tomio J, Kawana K, Tanaka T, Baba S, Kawata A, Eguchi S, Tsuruga T, Mori M, Adachi K, Nagamatsu T, Oda K, Yasugi T, Osuga Y, Fujii T.
  • Journal Title: Cancers (Basel). Volume: 12 Issue: 2 Pages: 1-15
  • DOI: 10.3390/cancers12020270
  • Peer Reviewed / Open Access
• [Journal Article] Differential expression of human papillomavirus 16-, 18-, 52-, and 58-derived transcripts in cervical intraepithelial neoplasia (2020)
  • Author(s): Baba S, Taguchi A, Kawata A, Hara K, Eguchi S, Mori M, Adachi K, Mori S, Iwata T, Mitsuhashi A, Maeda D, Komatsu A, Nagamatsu T, Oda K, Kukimoto I, Osuga Y, Fujii T, Kawana K.
  • Journal Title: Virol J Volume: 17 Issue: 1 Pages: 32-32
  • DOI: 10.1186/s12985-020-01306-0
  • NAID: 120007089054
  • Peer Reviewed / Open Access
• [Journal Article] Establishment and Molecular Phenotyping of Organoids from the Squamocolumnar Junction Region of the Uterine Cervix (2020)
  • Author(s): Maru Y, Kawata A, Taguchi A, Ishii Y, Baba S, Mori M, Nagamatsu T, Oda K, Kukimoto I, Osuga Y, Fujii T, Hippo Y.
  • Journal Title: Cancers (Basel) Volume: 12 Issue: 3 Pages: 694-694
  • DOI: 10.3390/cancers12030694
  • Peer Reviewed / Open Access
• [Journal Article] On-chip immunofluorescence analysis of single cervical cells using an electroactive microwell array with barrier for cervical screening (2019)
  • Author(s): Takeuchi Makoto、Nagasaka Kazunori、Yoshida Mina、Kawata Yoshiko、Miyagawa Yuko、Tago Saori、Hiraike Haruko、Wada-Hiraike Osamu、Oda Katsutoshi、Osuga Yutaka、Fujii Tomoyuki、Ayabe Takuya、Kim Soo Hyeon、Fujii Teruo
  • Journal Title: Biomicrofluidics Volume: 13 Issue: 4 Pages: 044107-044107
  • DOI: 10.1063/1.5089796
  • Peer Reviewed
• [Journal Article] Interleukin-17 is associated with expression of programmed cell death 1 ligand 1 in ovarian carcinoma. (2019)
  • Author(s): Aotsuka A, Matsumoto Y, Arimoto T, Kawata A, Ogishima J, Taguchi A, Tanikawa M, Sone K, Mori-Uchino M, Tsuruga T, Oda K, Kawana K, Osuga Y, Fujii T.
  • Journal Title: Cancer Sci. Volume: 110 Issue: 10 Pages: 3068-3078
  • DOI: 10.1111/cas.14174
  • Peer Reviewed / Open Access
• [Journal Article] Anti-tumor activity of dual inhibition of phosphatidylinositol 3-kinase and MDM2 against clear cell ovarian carcinoma (2019)
  • Author(s): Makii Chinami、Ikeda Yuji、Oda Katsutoshi、Wada-Hiraike Osamu、Kawana Kei、Hasegawa Kosei、Fujiwara Keiichi、Aburatani Hiroyuki、Osuga Yutaka、Fujii Tomoyuki
  • Journal Title: Gynecologic Oncology Volume: 155 Issue: 2 Pages: 331-339
  • DOI: 10.1016/j.ygyno.2019.08.028
  • Peer Reviewed
• [Journal Article] Anti-Tumor Effect of Inhibition of DNA Damage Response Proteins, ATM and ATR, in Endometrial Cancer Cells (2019)
  • Author(s): Takeuchi Makoto、Tanikawa Michihiro、Nagasaka Kazunori、Oda Katsutoshi、Kawata Yoshiko、Oki Shinya、Agapiti Chuwa、Sone Kenbun、Miyagawa Yuko、Hiraike Haruko、Wada-Hiraike Osamu、Kuramoto Hiroyuki、Ayabe Takuya、Osuga Yutaka、Fujii Tomoyuki
  • Journal Title: Cancers Volume: 11 Issue: 12 Pages: 1913-1913
  • DOI: 10.3390/cancers11121913
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Uterine adenomyosis is an oligoclonal disorder associated with KRAS mutations (2019)
  • Author(s): Inoue Satoshi、Hirota Yasushi、Ueno Toshihide、十人省略、Tanaka Yosuke、Sakata Seiji、Takeuchi Kengo、Muraoka Ayako、Osuka Satoko、Saito Tsuyoshi、Oda Katsutoshi、Osuga Yutaka、Terao Yasuhisa、Kawazu Masahito、Mano Hiroyuki
  • Journal Title: Nature Communications Volume: 10 Issue: 1 Pages: 1-13
  • DOI: 10.1038/s41467-019-13708-y
  • Peer Reviewed / Open Access
• [Journal Article] Histone methyltransferase SMYD2 selective inhibitor LLY-507 in combination with poly ADP ribose polymerase inhibitor has therapeutic potential against high-grade serous ovarian carcinomas. (2019)
  • Author(s): Kukita A, Sone K, Oda K, Hamamoto R, Kaneko S, Komatsu M, Wada M, Honjoh H, Kawata Y, Kojima M, Oki S, Sato M, Asada K, Taguchi A, Miyasaka A, Tanikawa M, Nagasaka K, Matsumoto Y, Wada-Hiraike O, Osuga Y, Fujii T
  • Journal Title: Biochem Biophys Res Commun Volume: in press Issue: 2 Pages: 30555-8
  • DOI: 10.1016/j.bbrc.2019.03.155
  • Peer Reviewed
• [Journal Article] Comprehensive assay for the molecular profiling of cancer by target enrichment from formalin‐fixed paraffin‐embedded specimens (2019)
  • Author(s): Kohsaka Shinji、Tatsuno Kenji、Ueno Toshihide、et al.
  • Journal Title: Cancer Science Volume: 110 Issue: 4 Pages: 1464-1479
  • DOI: 10.1111/cas.13968
  • Peer Reviewed / Open Access
• [Journal Article] Gynecological Cancers Translational, Research Implementation, and Harmonization: Gynecologic Cancer InterGroup Consensus and Still Open Questions. (2019)
  • Author(s): Bagnoli M, Shi TY, Gourley C, Speiser P, Reuss A, Nijman HW, Creutzberg CL, Scholl S, Negrouk A, Brady MF, Hasegawa K, Oda K, McNeish IA, Kohn EC, Oza AM, MacKay H, Millan D, Bennett K, Scott C, Mezzanzanica D
  • Journal Title: Cells Volume: 26 Issue: 3 Pages: 1-14
  • DOI: 10.3390/cells8030200
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Activation of Nrf2/Keap1 pathway by oral Dimethylfumarate administration alleviates oxidative stress and age-associated infertility might be delayed in the mouse ovary (2019)
  • Author(s): Akino Nana、Wada-Hiraike Osamu、Isono Wataru、Terao Hiromi、Honjo Harunori、Miyamoto Yuichiro、Tanikawa Michihiro、Sone Kenbun、Hirano Mana、Harada Miyuki、Hirata Tetsuya、Hirota Yasushi、Koga Kaori、Oda Katsutoshi、Fujii Tomoyuki、Osuga Yutaka
  • Journal Title: Reproductive Biology and Endocrinology Volume: 17 Issue: 1 Pages: 2323-2323
  • DOI: 10.1186/s12958-019-0466-y
  • Peer Reviewed / Open Access
• [Journal Article] Genomics to immunotherapy of ovarian clear cell carcinoma: Unique opportunities for management. (2018)
  • Author(s): Oda K, Hamanishi J, Matsuo K, Hasegawa K
  • Journal Title: Gynecol Oncol Volume: 151 Issue: 2 Pages: 381-389
  • DOI: 10.1016/j.ygyno.2018.09.001
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Usefulness of cell-free and concentrated ascites reinfusion therapy in the therapeutic management of advanced ovarian cancer patients with massive ascites (2018)
  • Author(s): Kawata Yoshiko、Nagasaka Kazunori、Matsumoto Yoko、Oda Katsutoshi、Tanikawa Michihiro、Sone Kenbun、Mori-Uchino Mayuyo、Tsuruga Tetsushi、Arimoto Takahide、Osuga Yutaka、Fujii Tomoyuki
  • Journal Title: International Journal of Clinical Oncology Volume: 24 Issue: 4 Pages: 420-427
  • DOI: 10.1007/s10147-018-1371-7
  • Peer Reviewed
• [Journal Article] Kaempferol, a natural dietary flavonoid, suppresses 17β?estradiol?induced survivin expression and causes apoptotic cell death in endometrial cancer (2018)
  • Author(s): Chuwa Agapiti、Sone Kenbun、Oda Katsutoshi、Tanikawa Michihiro、Kukita Asako、Kojima Machiko、Oki Shinya、Fukuda Tomohiko、Takeuchi Makoto、Miyasaka Aki、Kashiyama Tomoko、Ikeda Yuji、Nagasaka Kazunori、Mori?Uchino Mayuyo、Matsumoto Yoko、Wada?Hiraike Osamu、Kuramoto Hiroyuki、Kawana Kei、Osuga Yutaka、Fujii Tomoyuki
  • Journal Title: Oncology Letters Volume: 16 Pages: 6195-6201
  • DOI: 10.3892/ol.2018.9340
  • Peer Reviewed / Open Access
• [Journal Article] Blood Vessel Invasion Is a Strong Predictor of Postoperative Recurrence in Endometrial Cancer. (2018)
  • Author(s): Sato M, et al
  • Journal Title: Int J Gynecol Cancer. Volume: 7 Issue: 5 Pages: 875-881
  • DOI: 10.1097/igc.0000000000001262
  • Peer Reviewed
• [Journal Article] Intraperitoneal neutrophils activated by KRAS-induced ovarian cancer exert antitumor effects by modulating adaptive immunity. (2018)
  • Author(s): Yoshida M, Taguchi A, Kawana K, Ogishima J, Adachi K, Kawata A, Nakamura H, Sato M, Fujimoto A, Inoue T, Tomio K, Mori M, Nagamatsu T, Arimoto T, Koga K, Hiraike OW, Oda K, Kiyono T, Osuga Y, Fujii T
  • Journal Title: Int J Oncol Volume: 53 Pages: 1580-1590
  • DOI: 10.3892/ijo.2018.4504
  • Peer Reviewed
• [Journal Article] The oncogene KRAS promotes cancer cell dissemination by stabilizing spheroid formation via the MEK pathway. (2018)
  • Author(s): Ogishima J, Taguchi A, Kawata A, Kawana K, Yoshida M, Yoshimatsu Y, Sato M, Nakamura H, Kawata Y, Nishijima A, Fujimoto A, Tomio K, Adachi K, Nagamatsu T, Oda K, Kiyono T, Osuga Y, Fujii T
  • Journal Title: BMC Cancer Volume: 18 Issue: 1 Pages: 1-13
  • DOI: 10.1186/s12885-018-4922-4
  • Peer Reviewed / Open Access
• [Presentation] 乳がん、婦人科がん (2021)
  • Author(s): 織田克利
  • Organizer: 第4 1 回メディコピア教育講演シンポジウム
  • Invited
• [Presentation] 進行卵巣癌におけるVEGF阻害意義とゲノム医療の現状 (2021)
  • Author(s): 織田克利
  • Organizer: 第62回日本婦人科腫瘍学会学術講演会
  • Invited
• [Presentation] 婦人科がんにおけるがんゲノム医療とバイオマーカーの位置づけ (2020)
  • Author(s): 織田克利
  • Organizer: 第72回日本産科婦人科学会学術講演会
  • Invited
• [Presentation] キャンサーパネルについて (2020)
  • Author(s): 織田克利
  • Organizer: 第72回日本産科婦人科学会学術講演会
  • Invited
• [Presentation] Todai OncoPanel の経験と今後の展望 (2020)
  • Author(s): 織田克利
  • Organizer: 第26回日本遺伝性腫瘍学会学術集会
  • Invited
• [Presentation] PARP阻害剤の基礎と実臨床への展開 (2020)
  • Author(s): 織田克利
  • Organizer: 第58回日本癌治療学会学術講演会
  • Invited
• [Presentation] 婦人科がんの体細胞遺伝子変異の特徴とTodai OncoPanelの現状 (2020)
  • Author(s): 織田克利
  • Organizer: 第58回日本癌治療学会学術講演会
  • Invited
• [Presentation] 婦人科腫瘍におけるゲノム医療の展望 (2020)
  • Author(s): 織田克利
  • Organizer: 第38 回日本絨毛性疾患研究会
  • Invited
• [Presentation] ゲノム医療と女性医学 (2020)
  • Author(s): 織田克利
  • Organizer: 第35 回日本女性医学学会学術集会
  • Invited
• [Presentation] Mechanism targeting homologous recombination deficiencies in ovarian cancer. (2020)
  • Author(s): Katsutoshi Oda
  • Organizer: ASGO 2020, The 6th International Workshop on Gynecologic Oncology
  • Int'l Joint Research / Invited
• [Presentation] Translational and Genomic Research in gynecologic diseases. (2020)
  • Author(s): Katsutoshi Oda
  • Organizer: KGCR Autumn Symposium.
  • Int'l Joint Research / Invited
• [Presentation] AYA世代を中心とした婦人科がんにおけるクリニカルシーケンス (Todai OncoPanel)の現状 (2019)
  • Author(s): 織田 克利、谷川 道洋、原田 美由紀、大瀬戸 久美子、高阪 真路、大須賀 穣、 藤井 知行、宮川 清、間野 博行、油谷 浩幸、宮園 浩平
  • Organizer: 第78回日本癌学会学術総会
  • Invited
• [Presentation] がん遺伝子パネル検査の現状と発展的活用への展望 (2019)
  • Author(s): 織田 克利
  • Organizer: 日本人類遺伝学会第64回大会
  • Invited
• [Presentation] Translational research for GYN cancer: Current situation of Japan . (2019)
  • Author(s): Katsutoshi Oda
  • Organizer: 29th KGOG Symposium & 13th Korea-Japan Gynecologic Oncology Group Joint Meeting,
  • Int'l Joint Research / Invited
• [Presentation] Genomics to immunotherapy of ovarian clear cell carcinoma. (2019)
  • Author(s): Katsutoshi Oda
  • Organizer: The 6th Biennial Meeting of Asian Society of Gynecologic Oncology (ASGO 2019)
  • Int'l Joint Research / Invited
• [Presentation] 卵巣癌におけるベバシズマブ療法 ～基礎・臨床の双方向の視点から～ (2019)
  • Author(s): 織田 克利
  • Organizer: 第37回日本ヒト細胞学会学術集会
  • Invited
• [Presentation] （癌学会・癌治療学会・臨床腫瘍学会3学会合同シンポジウム：日本におけるがんゲノム医療体制の構築）東大オンコパネルを用いた先進医療の実践 (2018)
  • Author(s): 織田克利
  • Organizer: 第77回日本癌学会学術総会
  • Invited
• [Presentation] Precision Medicineの検証―分子標的治療薬：新規治療標的分子の発見と実用化 全エクソンシークエンス解析によるPARP阻害薬の新規バイオマーカーの提唱 (2018)
  • Author(s): 織田克利
  • Organizer: 第56回日本癌治療学会学術集会
  • Invited
• [Presentation] Clinical Sequencing by Todai OncoPanel, a Multiplex Cancerーrelated Gene Panel Testing (2018)
  • Author(s): Katsutoshi Oda
  • Organizer: 15th DIA Japan Annual Meeting
  • Invited
• [Presentation] Clinical sequencing by Todai OncoPanel, (a novel next-generation sequencing-based multiplex gene assay) in gynecological malignancies (2018)
  • Author(s): Katsutoshi Oda
  • Organizer: 60th Annual Meeting of the Japan Society of Gynecologic Oncology
  • Invited
• [Presentation] Clinical sequencing by Todai OncoPanel, (a novel next-generation sequencing-based multiplex gene assay) in gynecologic malignancies (2018)
  • Author(s): Katsutoshi Oda
  • Organizer: Anti-Cancer Treatment Japan
  • Int'l Joint Research / Invited
• [Book] 広汎子宮全摘術の実際 -東京大学 (2019)
  • Author(s): 松本陽子, 宮本雄一郎, 織田克利, 大須賀穣
  • Total Pages: 6
  • Publisher: 産科と婦人科
• [Book] 【がんクリニカルシークエンス検査の開発と臨床応用】 東大オンコパネルの開発 (2019)
  • Author(s): 高阪真路, 辰野健二, 織田克利
  • Total Pages: 4
  • Publisher: Precision Medicine
• [Book] 【特集 卵巣がん制圧へのマイルストーン】９．がん関連多遺伝子パネル検査（東大オンコパネル）の開発と実施. (2019)
  • Author(s): 織田克利, 谷川道洋, 高阪真路, 辰野健二
  • Total Pages: 6
  • Publisher: 産婦人科の実際
• [Book] 【特集「がんゲノミクスの解明と臨床応用」】 各論６．クリニカルシーケンシングの実際 (Clinical Sequencing for advanced cancer in Japan) (2019)
  • Author(s): 織田克利
  • Total Pages: 6
  • Publisher: BIO Clinica
• [Book] 【がん先進医療の最前線 先進医療NAVIGATOR】 35. マルチプレックス遺伝子パネル検査 固形がん B65. (2019)
  • Author(s): 織田克利
  • Total Pages: 3
  • Publisher: 先進医療フォーラム編集
• [Book] 産婦人科の実際 卵巣明細胞癌 (2018)
  • Author(s): 織田克利
  • Total Pages: 5
  • Publisher: 金原出版
• [Book] 医学のあゆみ 子宮体癌：分子生物学的背景──Precision medicineを見すえて (2018)
  • Author(s): 織田克利
  • Total Pages: 5
  • Publisher: 医歯薬出版株式会社
• [Remarks] 東大病院産婦人科 織田研究室
  • URL: http://plaza.umin.ac.jp/tkyobgyn/recruit/laboratory/oda.html
• [Remarks] 東京大学ホームページ
  • URL: https://www.u-tokyo.ac.jp/focus/ja/people/people002417.html
• [Patent(Industrial Property Rights)] PARP阻害剤に対する癌の感受性の予測方法および相同組む換え修復不全を有する癌の検出方法 (2019)
  • Inventor(s): 織田克利、長谷川幸清、山本尚吾、油谷浩幸
  • Industrial Property Rights Holder: 織田克利、長谷川幸清、山本尚吾、油谷浩幸
  • Industrial Property Rights Type: 特許
  • Filing Date: 2019
  • Overseas