Analysis of embryo receptivity mechanism via regulation of cell senescence in decidualizing human endometrial stromal cells
| Project/Area Number |
18K09273
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 56040:Obstetrics and gynecology-related
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| Research Institution | Juntendo University |
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Principal Investigator |
KURODA KEIJI 順天堂大学, 医学部, 非常勤講師 (60459162)
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| Project Period (FY) |
2018-04-01 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 不妊症 / 不育症 / 体外受精 / 子宮内膜 / 慢性子宮内膜炎 / 着床不全 / 妊娠 / 流産 / 子宮内膜ポリープ / 子宮腔内癒着 / 血栓性素因 / 甲状腺 / 子宮内膜脱落膜化 / 子宮内膜間質細胞 / 着床 / 細胞老化 / サーチュイン / レスベラトロール / 脱落膜化 |
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| Outline of Final Research Achievements |
Clinical studies of the OPtimization of Thyroid function, Immunity, and Uterine Milieu (OPTIMUM) treatment strategy were conducted to identify and treat the risk factors for implantation failure and miscarriage in the patients with a history of repeated implantation failure (RIF) or repeated pregnancy loss (RPL).
The ongoing pregnancy rates after first embryo transfer in the OPTIMUM group was significantly higher than that in the control group among women with RIF (57.4% and 21.4%, respectively; p <0.01). The live birth rate in the OPTIMUM group was significantly higher than that in the control group among women with RPL (78.1% and 42.3%, respectively; p = 0.002).
OPTIMUM treatment strategy is the first method that can simultaneously treat both RIF and RPL. We could report good pregnancy outcomes with the OPTIMUM based on our previous basic research on the human endometrium including chronic endometritis. In addition, we had published 15 English papers using this grant.
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| Academic Significance and Societal Importance of the Research Achievements |
今回の研究により何度の体外受精を行っても妊娠できない不妊症や流産を繰り返す不育症の多くの方が妊娠に導くことができることがわかった。もともと着床不全や原因不明不育症は、確立された治療法がなかった。科研費をもとに行ってきた我々の基礎および臨床研究をもとに、治療法が前進し現在問題になっている少子化に寄与すると思われる。
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Report
(6 results)
Research Products
(55 results)
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[Journal Article] Analysis of 122 triplet and 1 quadruplet pregnancies after single embryo transfer in Japan.2020
Author(s)
Yamashita S, Ikemoto Y, Ochiai A, Yamada S, Kato K, Ohno M, Segawa T, Nakaoka Y, Toya M, Kawachiya S, Sato Y, Takahashi T, Takeuchi S, Nomiyama M, Tabata C, Fujiwara T, Okamoto S, Kawamura T, Kawagoe J, Yamada M, Sato Y, Marumo G, Sugiyama R, Kuroda K
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Journal Title
Reprod Biomed Online
Volume: 40
Issue: 3
Pages: 374-380
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] 不育症に対するOPTIMUM (OPtimization of Thyroid function, Thrombophilia, IMmunity and Uterine Milieu) treatment strategyの治療効果の検討2022
Author(s)
黒田恵司, 池本裕子, 堀川隆, 森山梓, 中尾佳月, 壽圓裕康, 月花瑶子, 小代裕子, 髙見澤聡, 中川浩次, 杉山力一
Organizer
第74回日本産科婦人科学会学術講演会
Related Report
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[Presentation] Analysis of risk factors and treatment for recurrent implantation failure, OPTIMUM strategy2019
Author(s)
Yuko Matsumura, Tomoya Segawa, Tomoko Hashimoto, Junichiro Fukuda, Koji Nakagawa, Yuko Ikemoto, Asako Ochiai, Rie Ozaki, Keisuke Murakami, Shinichiro Ikuma, Rikikazu Sugiyama, Mari Kitade, Atsuo Itakura, Keiji Kuroda
Organizer
35rd Annual Meeting of ESHRE
Related Report
Int'l Joint Research
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