Comprehensive analysis of amniotic fluid microbiota for the prevention of preterm delivery: a fundamental study
| Project/Area Number |
18K09306
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 56040:Obstetrics and gynecology-related
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| Research Institution | Kurume University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 腟細菌叢 / 網羅的解析 / 妊娠 / 次世代シークエンサー / 正常妊婦 / 腟分泌物 / 菌叢解析 / 菌叢 / 早産 / 細菌叢 / 網羅的遺伝子解析 / 羊水 |
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| Outline of Final Research Achievements |
The vaginal microbiota during pregnancy, specifically the predominance of specific Lactobacillus species and the decrease in overall diversity, contribute to the maintenance of a healthy pregnancy. Conversely, a decrease in Lactobacillus quantity and an increase in microbiota diversity are indicative of bacterial vaginosis, which can be associated with factors such as a history of uterine surgeries and various known factors, including smoking.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究の成果は、早産に至る妊婦の腟細菌叢を妊娠初期に解析することより、その発症の予測および予防のための戦略を立てる上での基礎的データを提供するものと考えられる。
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Report
(6 results)
Research Products
(3 results)
