| Project/Area Number |
18K09309
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 56050:Otorhinolaryngology-related
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| Research Institution | Hokkaido University |
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Principal Investigator |
Kano Satoshi 北海道大学, 大学病院, 講師 (00374421)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 頭頸部癌 / 唾液腺癌 / 唾液腺導管癌 / 耳鼻咽喉科学 / 頭頸部腫瘍 |
|---|
| Outline of Final Research Achievements |
The gene expression pattern was generally consistent with the corresponding immunostaining classification. The expression levels of VEGFA, ERBB2(HER2), IGF1R, RB1, and XBP1 were higher, while those of SLIT2 and PTEN were lower in Ca-ex-PA than in de novo. The functions of those genes were concentrated in angiogenesis and AKT/PI3K signaling pathway.
Multiple machine learning methods show that VEGFA can be a candidate for the characteristic differences between Ca-ex-PA and de novo.
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| Academic Significance and Societal Importance of the Research Achievements |
高悪性度癌の一つである唾液腺導管癌の新しい発現メカニズムの一端を解明できた。唾液腺導管癌の発癌メカニズムにおいてVEGFAの関与に関する報告は過去にはなく、今後の治療薬開発へつながる新知見である。唾液腺導管癌はde novo型発症と多形腺腫由来型発症があるが、その内、多形腺腫由来型で特にVEGFRの高発現が認められていることから、これまでその原因が不明であった、多形腺腫の悪性化の解明にもつながる可能性が示唆された。
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