| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
We detected the expression of CD70 on the surface of nasopharyngeal carcinoma (NPC) cell lines. Immunohistological staining of biopsy samples from NPC patients showed that CD70 was found on malignant cells, while CD27-positive mononuclear cells infiltrated the tumor tissues. CD70 expression in malignant cells of tumor tissues significantly correlated with Epstein-Barr virus infection. Furthermore, soluble CD27 was present in sera of NPC patients at higher levels as compared to healthy individuals. These results suggest that the CD70/CD27 pathway may be an important factor in the development of NPC.
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