A study on the correlation between the therapeutic effect of BNCT and BPA-PET for head and neck cancer.

• Project/Area Number: 18K09312
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56050:Otorhinolaryngology-related
• Research Institution: Osaka Medical College
• Principal Investigator: Aihara Teruhito 大阪医科大学, 医学部, 特別職務担当教員(専門教授) (30268619)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: BNCT / 頭頸部癌 / ホウ素中性子捕捉療法 / 18FBPA-PET / 中性子束 / N/C比 / 加速器 / LAT1 / LAT1レセプター / 頭頸部がん / アミノ酸レセプター / α粒子 / 18F-BPA-PET

Outline of Final Research Achievements

PURPOSE: Boron Neutron Capture Therapy (BNCT) is a form of radiation therapy that utilizes alpha rays from thermal neutron capture of the boron atom. We examined whether the items of 1. BPA-PET, 2. DVH, and 3. nuclear cell (N/C) ratio would be the predictors of therapeutic effect.　As a result，1. The 18FBPA-PET study showed tumors with the lowest T/N ratio in GTV at 2.3 or higher were almost CR. 2. We analyzed DVH for our cases. Many non-effective cases fall below 20 Gy-Eq compared to the effective case. 3. The histopathological image of each cases were delineated by computer software, and the N/C ratio was calculated and the N/C ratio divided by the mean dose. We performed statistical analysis of the values for CR and non-CR groups. As a result, statistical significance was recognized.
We consider these three items as predictors of therapeutic effect, and our preliminary results demonstrated that BNCT is a potentially curative therapy for patients with head and neck cancer.

Academic Significance and Societal Importance of the Research Achievements

2020年3月に加速器中性子源が医療機器承認され，同年6月から「切除不能進行頭頸部癌，または再発頭頸部癌」において，保険治療が開始された．BNCTは治療前に抗腫瘍効果が予測可能な数少ない治療法であるが，その予測因子の検討は非常に不確実なものであった．今回の我々が出した結果は，18FBPA-PET，腫瘍中性子束線量，腫瘍組織のT/N比はBNCTの治療効果予測因子になり得る可能性があり，今後頭頸部癌治療の個別化を検討する中で，BNCT治療が選択される可能性を高めた結果だと考えられる．

Research Products

• [Journal Article] 【本格化するBNCTの最前線 研究開発から臨床応用までの最新動向と将来展望】BNCT実施施設からの報告 施設概要から治療の実際まで 大阪医科薬科大学関西BNCT共同医療センターにおける運用の実際(解説/特集) (2021)
  • Author(s): 粟飯原輝人
  • Journal Title: INNERVISION Volume: 36 Pages: 59-61
• [Journal Article] Boron neutron capture therapy for head and neck cancer: Relevance of nuclear-cytoplasmic volume ratio and anti-tumor effect. -A preliminary report- (2020)
  • Author(s): Teruhito Aihara, Junichi Hiratsuka, Nobuhiko Kamitani, Hirotake Nishimura, Koji Ono
  • Journal Title: Applied Radiation and Isotopes Volume: 163 Pages: 109212-109212
  • DOI: 10.1016/j.apradiso.2020.109212
  • Peer Reviewed
• [Journal Article] Verification for dose estimation performance of a Monte-Carlo based treatment planning system in University of Tsukuba (2020)
  • Author(s): Kumada Hiroaki, Takada Kenta, Aihara Teruhito, Matsumura Akira, Sakurai Hideyuki, Sakae Takeji
  • Journal Title: Applied Radiation and Isotopes Volume: 166 Pages: 109222-109222
  • DOI: 10.1016/j.apradiso.2020.109222
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Monitoring patient movement with boron neutron capture therapy and motion capture technology (2020)
  • Author(s): Kumada Hiroaki, Takada Kenta, Terunuma Toshiyuki, Aihara Teruhito, Matsumura Akira, Sakurai Hideyuki, Sakae Takeji
  • Journal Title: Applied Radiation and Isotopes Volume: 163 Pages: 109208-109208
  • DOI: 10.1016/j.apradiso.2020.109208
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Folate-appended cyclodextrin improves the intratumoral accumulation of existing boron compounds (2020)
  • Author(s): Matsumoto, Y. Hattori, K. Arima, H. Motoyama, K. Higashi, T. Ishikawa, H. Fukumitsu, N. Aihara, T. Nakai, K. Kumada, H. Sakurai, H.
  • Journal Title: Appl Radiat Isot Volume: 163 Pages: 109201-109201
  • DOI: 10.1016/j.apradiso.2020.109201
  • Peer Reviewed
• [Journal Article] ホウ素中性子捕捉療法（BNCT） (2020)
  • Author(s): 粟飯原輝人，河田了，小野公二
  • Journal Title: 臨床画像 Volume: 36 Pages: 196-202
• [Journal Article] 頭頸部がんに対するホウ素中性子捕捉療法の現状と今後の展望 (2019)
  • Author(s): 粟飯原輝人，平塚純一，東野正明，河田了，小野公二．
  • Journal Title: BIO Clinica Volume: 34 Pages: 433-440
• [Journal Article] 頭頸部がんに対するホウ素中性子捕捉療法の現状と今後の展望 (2019)
  • Author(s): 粟飯原輝人，平塚純一，東野正明，河田了，小野公二．
  • Journal Title: Precision Medicine Volume: 2 Pages: 100-107
• [Presentation] 頭頸部癌に対するホウ素中性子捕捉療法につい て．適応とその治療効果予測因子． (2020)
  • Author(s): 粟飯原輝人、平塚純一、神谷伸彦、東野正明、河 田了、二瓶圭二、小野公二
  • Organizer: 第58回日本癌治療学会
• [Presentation] 頭頸部癌に対するホウ素中性子捕捉療法の有用性と注意点 (2020)
  • Author(s): 粟飯原輝人
  • Organizer: 第44回日本頭頸部癌学会
  • Invited
• [Presentation] 頭頸部癌に対する加速器ホウ素中性子捕捉療法の現状 (2020)
  • Author(s): 粟飯原輝人
  • Organizer: 第33回日本喉頭科学会総会ならびに学術講演会
  • Invited
• [Presentation] BNCT for Head and Neck Cancer : Predictor of treatment effect. (2019)
  • Author(s): Teruhito Aihara, Junichi Hiratsuka, Nobuhiko Kamitani, Masaaki Higashino, Ryo Kawata, Koji Ono.
  • Organizer: 第57回日本がん治療学会
• [Presentation] NCT for Head and Neck Cancer : Summary of reactor irradiation. (2019)
  • Author(s): Teruhito Aihara, Junichi Hiratsuka, Nobuhiko Kamitani, Masaaki Higashino, Ryo Kawata, Koji Ono.
  • Organizer: PTCOG58
  • Int'l Joint Research
• [Presentation] BNCT for Head and Neck Cancer (2018)
  • Author(s): T. Aihara，J. Hiratsuka，N. Kamitani，H. Kumada，H. ishikawa，H. sakurai，K. Ono
  • Organizer: 第56回日本癌治療学会学術集会
• [Presentation] NCT for Head and Neck Cancer : Summary of reactor irradiation. (2018)
  • Author(s): Teruhito Aihara, Jyunichi Hiratsuka, Nobuhiko Kamitani, Nobuyoshi Fukumitsu, Hiroaki Kumada, Hideyuki Sakurai, Koji Ono.
  • Organizer: 18th International Congress on Neutron Capture Therapy
  • Int'l Joint Research