Host Immunity for Head and Neck Cancer Stem Cells

• Project/Area Number: 18K09355
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56050:Otorhinolaryngology-related
• Research Institution: Jichi Medical University
• Principal Investigator: NISHINO HIROSHI 自治医科大学, 医学部, 教授 (50245057)
• Project Period (FY): 2018-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: ALDH1A1 / CD39 / Foxp3 / CD4 / CD25 / FoxP3 / がん免疫 / 細胞周期 / 頭頸部癌 / CD44 / 癌幹細胞 / 免疫

Outline of Final Research Achievements

Tumor infiltrating lymphocytes (TILs) were observed CD39. That was showed those TILs attacked cancer cells. And TIL were also observed Foxp3. That means those TILs were exhausted after attacking cancer cells. CD44richALDHA1rich cancer cells were thought as cancer stem cells of heaad and neck cancer. When CD44richALDHA1rich cancer cells were rich in tumor, CD39richFoxp3rich TILs were poor in the maicro enviroment cancer tissue.

Academic Significance and Societal Importance of the Research Achievements

担がん宿主免疫より逃避する機序の解明につながる。免疫チュックポイント阻害薬を投与しても担がん宿主免疫能より逃避する機序が残存している場合には効果が期待できない。宿主免疫より逃避する機序の解明に役立つ。

Research Products

• [Journal Article] CT典型所見アトラス <咽喉頭・頭頸部領域>頸部腫瘤 (2022)
  • Author(s): 西野宏
  • Journal Title: 耳鼻咽喉科・頭頸部外科 Volume: 94 Pages: 358-362
• [Journal Article] Expression and localisation of methylthioadenosine phosphorylase (MTAP) in oral squamous cell carcinoma and their significance in epithelial-to-mesenchy (2021)
  • Author(s): Yusuke Amano, Daisuke Matsubara, Atsushi Kihara, Hiroshi Nishino, Yoshiyuki Mori, Toshiro Niki
  • Journal Title: Pathology Volume: 54 Issue: 3 Pages: 294-301
  • DOI: 10.1016/j.pathol.2021.05.101
  • Peer Reviewed / Open Access
• [Journal Article] Long-term survival after surgical resection of metachronous lung, brain and thyroid gland metastases from rectal cancer: A case report. (2021)
  • Author(s): Kazuma Rifu, Koji Koinuma, Hiroshi Nishino, Hisanaga Horie, Alan Kawarai Lefor, Naohiro Sata
  • Journal Title: International journal of surgery case reports Volume: 79 Pages: 318-322
  • DOI: 10.1016/j.ijscr.2021.01.054
  • Peer Reviewed / Open Access
• [Journal Article] Solitary adrenal metastasis from salivary duct carcinoma of the parotid gland successfully treated by surgery (2021)
  • Author(s): Amano Yusuke、Tsuji Kentaro、Kihara Atshushi、Matsubara Daisuke、Fukushima Noriyoshi、Nishino Hiroshi、Niki Toshiro
  • Journal Title: Medicine Volume: 100 Issue: 2 Pages: e24011-e24011
  • DOI: 10.1097/md.0000000000024011
  • Peer Reviewed / Open Access
• [Journal Article] A rare case of extraskeletal Ewing’s sarcoma arising from the larynx. (2020)
  • Author(s): Kono,E.,Sasaki,T.,Yamauchi,T.,Nishino,H
  • Journal Title: Acta Oto-Laryngologica Case Reports Volume: 5 Pages: 47-51
  • Peer Reviewed / Open Access
• [Journal Article] 小児甲状舌管癌と考えられた症例の再発経過と病理学的再検討 (2020)
  • Author(s): 翁長龍太郎、山内智彦、今吉正一郎、伊藤真人、西野宏
  • Journal Title: 小児耳鼻科 Volume: 41 Pages: 1047-1047
  • NAID: 130007939169
  • Peer Reviewed / Open Access
• [Journal Article] 原著 確定診断が困難であった鼻腔原発悪性末梢神経鞘腫疑いの1例 (2019)
  • Author(s): 塚本裕司、佐々木徹、西野宏
  • Journal Title: 耳鼻咽喉科・頭頸部外科 Volume: 91 Issue: 6 Pages: 473-477
  • DOI: 10.11477/mf.1411202102
  • ISSN: 0914-3491, 1882-1316
  • Year and Date: 2019-05-20
  • Peer Reviewed
• [Journal Article] Issues Related to Treatment of Malignant Tumors of the Maxillary Sinus (2019)
  • Author(s): 西野宏
  • Journal Title: Practica Oto-Rhino-Laryngologica Volume: 112 Issue: 6 Pages: 351-355
  • DOI: 10.5631/jibirin.112.351
  • NAID: 130007657394
  • ISSN: 0032-6313, 1884-4545
  • Peer Reviewed / Open Access
• [Presentation] 上顎洞がんの治療 (2022)
  • Author(s): 西野宏
  • Organizer: 第41回日本画像医学会(招待講演)
  • Invited
• [Presentation] 異時性に発症した両側外耳道癌例 (2020)
  • Author(s): 甲州亮太、伊藤真人、山内智彦、長友孝文、西野宏
  • Organizer: 第30回日本頭頚部外科学会総会ならびに学術講演会
• [Presentation] 膝窩嚢胞（ベーカー嚢胞）にて発覚したニホルマブによる関節リウマチの１例 (2020)
  • Author(s): 甲州亮太、長友孝文、山内智彦、西野宏
  • Organizer: 第121回日本耳鼻咽喉科学会学術講演会
• [Presentation] 喉頭から下咽頭領域の骨外性Ewing肉腫の1症例 (2019)
  • Author(s): 光野瑛美、西野宏
  • Organizer: 耳鼻咽喉科臨床学会
• [Presentation] CDDP耐性再発転移頭頸部癌に対するWeekly PTX/Cmab治療 (2019)
  • Author(s): 西野宏、山内智彦、長友孝文、翁長龍太郎、上村佐恵子、髙橋さとか、濱野有美子、塚本裕司、手塚綾乃、光野瑛美、長谷川智宏
  • Organizer: 日本耳鼻咽喉科学会
• [Presentation] ニボルマブが有効であった粘膜原発悪性黒色腫の一例 (2019)
  • Author(s): 翁長龍太郎、山内智彦、長友孝文、西野宏
  • Organizer: 日本耳鼻咽喉科学会
• [Presentation] 小児甲状舌管癌の術後再発例 (2019)
  • Author(s): 翁長龍太郎、山内智彦、今吉正一郎、伊藤真人、西野宏
  • Organizer: 小児耳鼻咽喉科学会
• [Presentation] Results of Multidiscliplinary Approach of Patients with T4b Malignant Tumors observed Middle Cranial Fossa Invasion of Maxillary Sinus (2019)
  • Author(s): Ryutaro Onaga, Hiroshi Nishino
  • Organizer: 15th Japan-Taiwan Conference ob Otolaryngology-Heaf and Neck Surgery
  • Int'l Joint Research