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Study of Adjuvant Immunotherapy for Allergic Diseases

Research Project

Project/Area Number 18K09360
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 56050:Otorhinolaryngology-related
Research InstitutionNippon Medical School

Principal Investigator

OKUBO KIMIHIRO  日本医科大学, 大学院医学研究科, 大学院教授 (10213654)

Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywordsスギ花粉症 / アレルゲン免疫療法 / バイオマーカー / 〇スギ花粉症 / 花粉症 / アジュバント / モデル動物 / アレルギー性鼻炎 / 免疫療法
Outline of Final Research Achievements

Allergen immunotherapy for allergic rhinitis is characterized by the fact that, unlike drug therapy, its effects persist even after treatment is stopped. We found that the post-treatment mechanism of this effect is analogous to the balance of specific IgE and specific IgG4 antibody production. In sublingual immunotherapy for cedar pollinosis, we found that IgE decreased to the same level as placebo at the end of treatment, whereas IgG4 increased after treatment, and IgG4 production continued to increase in response to cedar pollen dispersal. In addition, the higher the level of Il-10 among serum cytokines before sublingual immunotherapy, the more IgG4 remained elevated.

Academic Significance and Societal Importance of the Research Achievements

アレルゲン免疫療法の特徴である後効果に関しての基礎的な検討は少ない。我々はこの後効果発現機序を特異的IgE、特異的IgG4抗体産生のバランスにより類推できることを見出した。これによりアレルゲン免疫療法を実施する患者の抗原特異的IgE、IgG4産生の追跡により、その患者が治療を止めた後も、どの程度治療後効果が継続できるか類推可能となる。このことにより治療継続期間、後効果の継続程度で医療資源の減少を導き、医療費の削減できる可能性を示唆した。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (8 results)

All 2022 2021 2020 2019 2018

All Journal Article (8 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 6 results,  Open Access: 6 results)

  • [Journal Article] Disease-modifying effect of Japanese cedar pollen sublingual immunotherapy tablets.2022

    • Author(s)
      Yonekura S, Gotoh M, Kaneko S, Maekawa Y, Okubo K, Okamoto Y
    • Journal Title

      J Allergy Clin Immunol in Pract.

      Volume: 9 Issue: 11 Pages: 4103-4116

    • DOI

      10.1016/j.jaip.2021.06.060

    • Related Report
      2021 Annual Research Report
  • [Journal Article] Long-term sublingual immunotherapy provides better effects for patients with Japanese cedar pollinosis2021

    • Author(s)
      Hamada Satoko、Kobayashi Yoshiki、Sakamoto Daiki、Shimamura Akihiro、Kuroda Kazumichi、Kawachi Risaki、Kanda Akira、Asako Mikiya、Gotoh Minoru、Okubo Kimihiro、Tomoda Koichi、Iwai Hiroshi
    • Journal Title

      Auris Nasus Larynx

      Volume: - Issue: 4 Pages: 646-652

    • DOI

      10.1016/j.anl.2021.01.003

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Long-term treatment of Japanese cedar pollinosis with Japanese cedar pollen SLIT drops and persistence of treatment effect: A post-marketing clinical trial2021

    • Author(s)
      Nomura Y, Okubo K, Nakamura T, Sawaki S, Kitagou H, Idei N, Kaneko S, Kobayashi S, Tanaka Y, Okamoto Y
    • Journal Title

      Allergology International

      Volume: 70 Issue: 1 Pages: 96-104

    • DOI

      10.1016/j.alit.2020.05.008

    • NAID

      130007966818

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2021 Annual Research Report 2020 Research-status Report
  • [Journal Article] Add on omalizumab for inadequently controlled severe pollinosis despite standard-of-care; a randomized study.2020

    • Author(s)
      Okubo K, Okano M, Sato N, Tamaki Y, Suzuki H, Uddin A, Fogel R
    • Journal Title

      J Allergy Clin Immunol Pract.

      Volume: 8(9) Issue: 9 Pages: 3130-3140.e2

    • DOI

      10.1016/j.jaip.2020.04.068

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Decreased numbers of metachromatic cells in nasal swabs in Japanese cedar pollinosis following sublingual immunotherapy.2020

    • Author(s)
      Otsuka K, Otsuka H, Matsune S, Okubo K
    • Journal Title

      Immun Inflamm Dis

      Volume: 8(3) Issue: 3 Pages: 333-341

    • DOI

      10.1002/iid3.314

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Long-term efficacy and dose-finding trial of Japanese cedar pollen SLIT tablet.2019

    • Author(s)
      Gotoh M, Yonekura S, Imai T, Kaneko S, Horikawa E, Konno A, Okamoto Y, Okubo K
    • Journal Title

      J Allergy Clin Immunol Pract

      Volume: 7 Issue: 4 Pages: 1287-1297

    • DOI

      10.1016/j.jaip.2018.11.044

    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Anti-Inflammatory Effects of EM900 on Cultured Human Nasal Epithelial Cells2018

    • Author(s)
      Wakayama N, Matsune S, Takahara E, Sekine K, Yoshioka Y, Ishida M, Yamaguchi S, Okubo K, Sunazuka T, Omura S
    • Journal Title

      Journal of Nippon Medical School

      Volume: 85 Issue: 5 Pages: 265-270

    • DOI

      10.1272/jnms.JNMS.2018_85-42

    • NAID

      130007520433

    • ISSN
      1345-4676, 1347-3409
    • Year and Date
      2018-10-15
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Serum Cytokine Interactions Are Implicated in the Mechanism of Action of Sublingual Immunotherapy for Japanese Cedar Pollinosis2018

    • Author(s)
      Shimada K, Gotoh M, Okubo K, Hiroi T, Kaminuma O, Nakaya A
    • Journal Title

      Journal of Nippon Medical School

      Volume: 85 Issue: 5 Pages: 250-258

    • DOI

      10.1272/jnms.JNMS.2018_85-40

    • NAID

      130007520427

    • ISSN
      1345-4676, 1347-3409
    • Year and Date
      2018-10-15
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research

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Published: 2018-04-23   Modified: 2023-01-30  

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