Investigation of pathology of sensorineural hearing loss from inflammatory cytokines and application for treatment

• Project/Area Number: 18K09376
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56050:Otorhinolaryngology-related
• Research Institution: National Hospital Organization Nagoya Medical Center (2022); Nagoya University (2018-2021)
• Principal Investigator: Teranishi Masaaki 独立行政法人国立病院機構(名古屋医療センター臨床研究センター), 耳鼻咽喉科, 医長 (20335037)
• Project Period (FY): 2018-04-01 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 内耳 / サイトカイン / 内耳性難聴 / 遺伝子多型 / 炎症性サイトカイン

Outline of Final Research Achievements

Because genetic factors may contribute partly to the etiologies of inner
ear diseases, we investigated the association between genetic polymorphisms located in genes related to the inflammatory pathway and susceptibility to Meniere disease and tinnitus. We found that uncoupling protein 1, 2 polymorphisms were significantly associated with the risk of tinnitus and platelet glycoprotein Ia polymorphism was associated with the risk of Meniere disease.

Academic Significance and Societal Importance of the Research Achievements

内耳性難聴や耳鳴は、病態は不明の点が多いが、環境要因や遺伝要因含めた多因子によるものと考えられる。本研究の成果により耳鳴やメニエール病で遺伝要因の関与が考えられた。内耳MRI画像の進歩により内耳血管透過性亢進や内リンパ水腫の評価が可能となった。画像所見も含めて病態を分類し、内耳性難聴や耳鳴の個別化医療に向けての基礎的なデータになることが考えられる。

Research Products

• [Journal Article] Relationship between tinnitus and olfactory dysfunction: audiovisual, olfactory, and medical examinations. (2023)
  • Author(s): Katayama N, Yoshida T, Nakashima T, Ito Y, Teranishi M, Iwase T, Sugiura S, Goto K, Uchida Y, Taki Y, Nakada T, Tada A, Suzuki H, Nakano Y, Shimono M, Saji N, Kogure A, Shimizu E, Sone M, Hamajima N.
  • Journal Title: Front Public Health Volume: 11 Pages: 1-13
  • DOI: 10.3389/fpubh.2023.1124404
  • Peer Reviewed / Open Access
• [Journal Article] Pathological significance and classification of endolymphatic hydrops in otological disorders (2022)
  • Author(s): Sone M, Yoshida T, Sugimoto S, Kobayashi M, Teranishi M, Naganawa S.
  • Journal Title: Nagoya Journal of Medical Science Volume: 84 Issue: 3 Pages: 497-505
  • DOI: 10.18999/nagjms.84.3.497
  • ISSN: 0027-7622
  • URL: https://nagoya.repo.nii.ac.jp/records/2003742
  • Peer Reviewed
• [Journal Article] Dilatation of the Endolymphatic Space in the Ampulla of the Posterior Semicircular Canal: A New Clinical Finding Detected on Magnetic Resonance Imaging (2021)
  • Author(s): Masaru Morioka, Satofumi Sugimoto, Tadao Yoshida, Masaaki Teranishi, Masumi Kobayashi, Naoki Nishio, Naomi Katayama, Shinji Naganawa, Michihiko Sone
  • Journal Title: Otol Neurotol. Volume: - Issue: 6 Pages: e643-e647
  • DOI: 10.1097/mao.0000000000003073
  • Peer Reviewed / Open Access
• [Journal Article] Evaluation of the blood-perilymph barrier in ears with endolymphatic hydrops. (2021)
  • Author(s): Yoshida T, Kobayashi M, Sugimoto S, Teranishi M, Naganawa S, Sone M.
  • Journal Title: Acta Otolaryngol Volume: 141 Issue: 8 Pages: 736-741
  • DOI: 10.1080/00016489.2021.1957500
  • NAID: 120007183214
  • Peer Reviewed
• [Journal Article] 突発性難聴治療のエビデンス 急性感音難聴診療の手引きより (2021)
  • Author(s): 寺西 正明, 曾根 三千彦
  • Journal Title: ENTONI Volume: 258 Pages: 45-50
• [Journal Article] Imaging of endolymphatic hydrops on a vertigo attack of Meniere’s disease (2021)
  • Author(s): Nakada T, Teranishi M, Sugiura S, Uchida Y, Naganawa S, Sone M.
  • Journal Title: Nagoya Journal of Medical Science Volume: 83 Issue: 1 Pages: 209-216
  • DOI: 10.18999/nagjms.83.1.209
  • NAID: 120007127300
  • ISSN: 0027-7622
  • URL: https://nagoya.repo.nii.ac.jp/records/2000218
  • Peer Reviewed / Open Access
• [Journal Article] めまいを伴う突発性難聴 (2020)
  • Author(s): 寺西 正明, 曾根 三千彦
  • Journal Title: ENTONI Volume: 249 Pages: 83-88
• [Journal Article] 急性感音難聴 メニエール病 (2020)
  • Author(s): 寺西 正明, 曾根 三千彦
  • Journal Title: JOHNS Volume: 36 Pages: 19-22
• [Journal Article] 水腫推定検査3(画像検査)と診断 (2019)
  • Author(s): 寺西 正明, 曾根 三千彦
  • Journal Title: ENTONI Volume: 234 Pages: 33-37
• [Journal Article] 症状からみた鑑別診断 難聴/耳鳴/耳閉感 (2019)
  • Author(s): 寺西 正明, 曾根 三千彦
  • Journal Title: 耳鼻咽喉科・頭頸部外科 Volume: 91 Pages: 53-57
• [Journal Article] Association between Uncoupling Protein 2 Gene Ala55val Polymorphism and Sudden Sensorineural Hearing Loss. (2018)
  • Author(s): Koide Y, Teranishi M, Sugiura S, Uchida Y, Nishio N, Kato K, Otake H, Yoshida T, Otsuka R, Ando F, Shimokata H, Hasegawa Y, Nakashima T, Sone M.
  • Journal Title: J Int Adv Otol Volume: 14 Issue: 2 Pages: 166-169
  • DOI: 10.5152/iao.2018.5442
  • Peer Reviewed / Open Access
• [Journal Article] Gd静注法によるMRIと内リンパ水腫 (2018)
  • Author(s): 寺西 正明, 曾根 三千彦
  • Journal Title: Equilibrium Research Volume: 77 Pages: 99-103
  • NAID: 130007382854
  • Peer Reviewed
• [Presentation] Genetic polymorphisms and susceptibility to inner ear diseases (2019)
  • Author(s): Masaaki Teranishi
  • Organizer: 15th Japan-Taiwan Conference on Otolaryngology-Head and Neck Surgery
  • Int'l Joint Research
• [Presentation] Association of polymorphisms in genes encoding uncoupling protein 1, 2 and protein kinase C-eta with the risk of tinnitus in community-dwelling middle-aged to elderly Japanese (2019)
  • Author(s): Masaaki Teranishi, Saiko Sugiura, Takafumi Nakada, Hirokazu Suzuki, Yasue Uchida, Rei Otsuka, Chikako Tange, Fujiko Ando, Hiroshi Shimokata, Michihiko Sone
  • Organizer: 56th Inner Ear Biology Workshop
  • Int'l Joint Research
• [Presentation] 中高年者の耳鳴における血流・血管障害関連遺伝子多型の検討 (2019)
  • Author(s): 寺西 正明, 杉浦 彩子, 中田 隆文, 鈴木 宏和, 内田 育恵, 曾根 三千彦
  • Organizer: 第120回日本耳鼻咽喉科学会総会
• [Presentation] 中高年者の耳鳴における遺伝子多型の検討 (2018)
  • Author(s): 寺西 正明, 杉浦 彩子, 中田 隆文, 内田 育恵, 曾根 三千彦
  • Organizer: 第63回日本聴覚医学会総会・学術講演会
• [Presentation] Evaluation of endolymphatic hydrops with MR imaging (2018)
  • Author(s): Teranishi M
  • Organizer: 17th KOREA-JAPAN Joint Meeting of Otorhinolaryngology-Head and Neck Surgery
  • Int'l Joint Research