| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
We could visualize the internal structures of the normal and hydropic cochleae of guinea pigs in vivo by using OCT. Intratympanic administration of isosorbide, the therapeutic agent for Meniere's disease, decreased the size of the scala media both in the normal and hydropic cochleae. In the normal cochlea, intratympanic administration of isosorbide seems to have minimal effect on the cochlea, because Reissner’s membrane became only flat. In the hydropic cochlea, intratympanic administration of isosorbide decreased the hydrops rapidly and strongly. These effects on the scala media were concentration-dependent. These results indicate that middle ear instillation of isosorbide may become another option for the treatment of Meniere’s disease.
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