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In vivo imaging of decompression effect on endolymphatic hydrops by OCT

Research Project

Project/Area Number 18K09378
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 56050:Otorhinolaryngology-related
Research InstitutionKobe University

Principal Investigator

Kakigi Akinobu  神戸大学, 医学研究科, 特命教授 (60243820)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsメニエール病 / 内リンパ水腫 / 鼓室内投与 / OCT / イソソルビド / 浸透圧利尿剤 / モルモット
Outline of Final Research Achievements

We could visualize the internal structures of the normal and hydropic cochleae of guinea pigs in vivo by using OCT. Intratympanic administration of isosorbide, the therapeutic agent for Meniere's disease, decreased the size of the scala media both in the normal and hydropic cochleae. In the normal cochlea, intratympanic administration of isosorbide seems to have minimal effect on the cochlea, because Reissner’s membrane became only flat. In the hydropic cochlea, intratympanic administration of isosorbide decreased the hydrops rapidly and strongly. These effects on the scala media were concentration-dependent. These results indicate that middle ear instillation of isosorbide may become another option for the treatment of Meniere’s disease.

Academic Significance and Societal Importance of the Research Achievements

OCTを用いた蝸牛内構造のin vivoイメージングは他に報告がなく本研究の独創的な点である。また、メニエール病の治療を薬剤の鼓室内投与によって行うことは全身投与に比べ副作用のリスクが軽減できることが利点である。本研究ではメニエール病の治療薬の効果をリアルタイムに観察できたことが新たな点であり、種々の薬物の効果判定にも役立つことが期待できる。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (8 results)

All 2020 2019 2018

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 2 results) Presentation (4 results) (of which Int'l Joint Research: 3 results,  Invited: 3 results)

  • [Journal Article] Live imaging and functional changes of the inner ear in an animal model of Meniere’s disease2020

    • Author(s)
      Kakigi Akinobu、Egami Naoya、Uehara Natsumi、Fujita Takeshi、Nibu Ken-ichi、Yamashita Shinji、Yamasoba Tatsuya
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 12271-12271

    • DOI

      10.1038/s41598-020-68352-0

    • NAID

      120006879537

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A possible mechanism of the formation of endolymphatic hydrops and its associated inner ear disorders2020

    • Author(s)
      Takeda Taizo、Takeda Setsuko、Kakigi Akinobu
    • Journal Title

      Auris Nasus Larynx

      Volume: 47 Issue: 1 Pages: 25-41

    • DOI

      10.1016/j.anl.2019.09.005

    • Related Report
      2020 Annual Research Report 2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Endocytosis of CF in marginal cells of stria vascularis regulated by ROCK and MLCK signaling cascade, but not G-proteins2019

    • Author(s)
      Kakigi Akinobu、Okada Teruhiko、Takeda Taizo、Uehara Natsumi、Nibu Ken-ichi
    • Journal Title

      Auris Nasus Larynx

      Volume: 46 Issue: 5 Pages: 790-796

    • DOI

      10.1016/j.anl.2019.01.007

    • NAID

      120006728085

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Histamine-Induced Endolymphatic Hydrops2018

    • Author(s)
      Taizo Takeda、Setsuko Takeda、Akinobu Kakigi、Naoya Egami、Rie Nishioka、Natsumi Uehara、Ken-ichi Nibu
    • Journal Title

      Journal of Otolaryngology: Research

      Volume: 1(2) Pages: 120-120

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 自発眼振検査-メニエール病の病態2020

    • Author(s)
      柿木章伸
    • Organizer
      第30回日本耳科学会総会学術講演会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Cochlear Function in New Animal Model of Meniere’s Disease2018

    • Author(s)
      Akinobu Kakigi, Naoya Egami, Takuma Shirahata, Shinji Yamashita, Ken-ichi Nibu, Tatsuya Yamasoba
    • Organizer
      AAO-HNSF Annual Meeting & OTO Experience
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Pathophysiology of Meniere’s disease2018

    • Author(s)
      Akinobu Kakigi
    • Organizer
      the 6th East Asian Symposium on Otology
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Cochlear function in new animal model of Meniere's disease2018

    • Author(s)
      Akinobu Kakigi
    • Organizer
      17th KJJM ORL-HNS Symposium
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited

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Published: 2018-04-23   Modified: 2022-01-27  

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