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Improvement of brain metabolism and cognitive function after cochlear implantation in profoundly deafeaned elderly patients

Research Project

Project/Area Number 18K09392
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 56050:Otorhinolaryngology-related
Research InstitutionKobe City Medical Center General Hospital(First Clinical Division, Second Clinical Division, Third

Principal Investigator

Naito Yasushi  地方独立行政法人神戸市民病院機構神戸市立医療センター中央市民病院(第1診療部、第2診療部、第3診療部, 中央市民病院, 参事 (70217628)

Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords高齢者 / 高度難聴 / 脳代謝 / PET / 人工内耳 / 脳機能 / FDG / 高齢 / 認知機能 / 重度難聴
Outline of Final Research Achievements

Brain metabolism was measured using FDG-PET in elderly patients with profound hearing loss who met the criteria for cochlear implantation. In elderly patients with profound deafness without cochlear implants, hypometabolic areas were observed in the parietal and dorsal frontal lobes as well as in the temporal cortex. On the other hand, in the elderly patients who had been using cochlear implants for more than one year, hypometabolism was observed in the anterior half of the superior temporal gyrus and part of the dorsal frontal lobe, but the difference from normal hearing subjects was smaller than in the patients with no cochlear implants. The results suggest that the effects of profound hearing loss in the elderly on brain metabolism are more extensive than just in the auditory cortex. In addition, auditory compensation with cochlear implants may reduce the decline of brain function due to profound deafness, but these issues need to be verified in a larger number of cases.

Academic Significance and Societal Importance of the Research Achievements

近年、加齢性の難聴は聴覚や言語聴取の低下だけでなく認知機能低下のリスクを高めることが報告されており、その機序について種々の説が挙げられているが、いまだ詳細は明らかになっていない。本研究成果の学術的意義は、高度難聴が高齢者の脳の糖代謝を低下させることと、聴覚補償でそれを軽減させる可能性を初めて示した点にある。難聴は補正可能な認知症の危険因子の中で最大のものとされており、聴覚検査と脳代謝計測で難聴と脳機能の関係を定量的に明らかにし、高齢者の認知症予防について具体的な方向を示した点で本研究成果の社会的意義は大きいと考える。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (58 results)

All 2022 2021 2020 2019 2018

All Journal Article (14 results) (of which Peer Reviewed: 13 results,  Open Access: 3 results) Presentation (41 results) (of which Int'l Joint Research: 8 results,  Invited: 18 results) Book (3 results)

  • [Journal Article] High Riding Jugular Bulb Protruding Into Tympanic Cavity: Longitudinal Radiologic Study in a Deaf Child2022

    • Author(s)
      Ueda K, Yamazaki H, Michida T, Shinohara S, Naito Y.
    • Journal Title

      Ear Nose Throat J

      Volume: - Issue: 11 Pages: 707-710

    • DOI

      10.1177/01455613221079494

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Detailed clinical features and genotype-phenotype correlation in an OTOF-related hearing loss cohort in Japan.2022

    • Author(s)
      Iwasa YI, Nishio SY, Yoshimura H,..., Naito Y,..., Usami SI
    • Journal Title

      Hum Genet

      Volume: 141 Issue: 3-4 Pages: 865-875

    • DOI

      10.1007/s00439-021-02351-7

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Etiology of hearing loss affects auditory skill development and vocabulary development in pediatric cochlear implantation cases.2022

    • Author(s)
      Nishio SY, Moteki H, Miyagawa M,..., Naito Y,..., Usami SI
    • Journal Title

      Acta Otolaryngol

      Volume: 142 Issue: 3-4 Pages: 308-315

    • DOI

      10.1080/00016489.2022.2065027

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multicenter phase III trial of regenerative treatment for chronic tympanic membrane perforation2021

    • Author(s)
      Kanemaru Shin-ichi、Kanai Rie、Omori Koichi、Yamamoto Norio、Okano Takayuki、Kishimoto Ippei、Ogawa Kaoru、Kanzaki Sho、Fujioka Masato、Oishi Naoki、Naito Yasushi、Kakehata Seiji、Nakamura Hajime、Yamada Shinobu、Omae Kaoru、Kawamoto Atsuhiko、Fukushima Masanori
    • Journal Title

      Auris Nasus Larynx

      Volume: online ahead of prin Issue: 6 Pages: 1054-1060

    • DOI

      10.1016/j.anl.2021.02.007

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative Assessment of the Wearing Situations and Sound Environments of Children with Cochlear Implants Using Log Data.2020

    • Author(s)
      大西晶子, 諸頭三郎, 前川圭子, 山崎朋子, 玉谷輪子,藤井直子,藤原敬三, 内藤 泰
    • Journal Title

      AUDIOLOGY JAPAN

      Volume: 63 Issue: 6 Pages: 531-538

    • DOI

      10.4295/audiology.63.531

    • NAID

      130007970024

    • ISSN
      0303-8106, 1883-7301
    • Year and Date
      2020-12-28
    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Habilitation of children after cochlear implantation.2020

    • Author(s)
      諸頭三郎, 内藤 泰
    • Journal Title

      AUDIOLOGY JAPAN

      Volume: 63 Issue: 6 Pages: 494-508

    • DOI

      10.4295/audiology.63.494

    • NAID

      130007969915

    • ISSN
      0303-8106, 1883-7301
    • Year and Date
      2020-12-28
    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Characteristics of cochlear implant programming in children with inner ear malformations.2020

    • Author(s)
      諸頭三郎, 山崎朋子, 玉谷輪子, 藤井直子, 山崎博司, 藤原敬三, 内藤 泰
    • Journal Title

      AUDIOLOGY JAPAN

      Volume: 63 Issue: 6 Pages: 509-517

    • DOI

      10.4295/audiology.63.509

    • NAID

      130007970018

    • ISSN
      0303-8106, 1883-7301
    • Year and Date
      2020-12-28
    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cochlear implantation in children with cochlear malformations: long-term postoperative outcomes and indications of bilateral cochlear implantation.2020

    • Author(s)
      諸頭三郎, 山崎朋子, 玉谷輪子, 藤井直子, 山崎博司, 藤原敬三, 内藤 泰
    • Journal Title

      AUDIOLOGY JAPAN

      Volume: 63 Issue: 6 Pages: 539-547

    • DOI

      10.4295/audiology.63.539

    • NAID

      130007970017

    • ISSN
      0303-8106, 1883-7301
    • Year and Date
      2020-12-28
    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] 人工聴覚器のマッピング2020

    • Author(s)
      諸頭三郎, 内藤 泰
    • Journal Title

      耳鼻咽喉科・頭頚部外科

      Volume: 92 Pages: 58-65

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] First Implant-Induced Changes in Rostral Brainstem Impair Second Implant Outcomes in Sequential Bilateral Cochlear Implant Children With Long Inter-Implant Delay2019

    • Author(s)
      Kishimoto I, Yamazaki H, Naito Y, Moroto S, Yamazaki T
    • Journal Title

      Otol Neurotol

      Volume: 40 Issue: 4 Pages: 367-372

    • DOI

      10.1097/mao.0000000000002130

    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comprehensive analysis of syndromic hearing loss patients in Japan2019

    • Author(s)
      Ideura Michie、Nishio Shin-ya、Sugahara Kazuma、他
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 11976-11976

    • DOI

      10.1038/s41598-019-47141-4

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tinnuitus handicap inventory耳鳴苦痛度質問票改訂版の信頼性と妥当性に関する検討2019

    • Author(s)
      大政遥香, 神崎 晶, 高橋真理子, 佐藤宏昭, 和田哲郎, 川瀬哲明, 内藤 泰, 村上信五, 原 晃, 小川 郁
    • Journal Title

      Audiology Japan 62: , 2019

      Volume: 62 Pages: 607-614

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] 人工内耳の適応と術前の準備2018

    • Author(s)
      山崎朋子, 内藤 泰
    • Journal Title

      Rehabilitation Engineering

      Volume: 33 Pages: 126-129

    • NAID

      130007740937

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] 中枢性聴覚検査2018

    • Author(s)
      山崎朋子, 内藤 泰
    • Journal Title

      JOHNS

      Volume: 34 Pages: 867-870

    • Related Report
      2018 Research-status Report
  • [Presentation] Measurement of auditory cortical responses using fNIRS in CI children with inner ear malformations2021

    • Author(s)
      Yamazaki H, Naito Y, Moroto S, Yamazaki T, Tamaya R, Fujii N
    • Organizer
      13th Asia Pacific Symposium on Cochlear Implants and Related Sciences
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 先天性高度難聴小児のコミュニケーションモードと脳機能2021

    • Author(s)
      内藤 泰、藤原敬三、山崎博司、諸頭三郎、山崎朋子 、玉谷輪子、藤井直子、宇佐美真一、茂木英明、森 壽子
    • Organizer
      第66回日本聴覚医学会総会・学術講演会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 人工内耳を長期装用している後期高齢者の検討2021

    • Author(s)
      安本眞美、内藤泰、山崎博司、藤原敬三、濵口清海、道田哲彦、戸部陽太、上田啓史
    • Organizer
      第31回日本耳科学会総会・学術講演会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Predicting outcomes in children; including need for early intervention2021

    • Author(s)
      Yasushi Naito, Hiroshi Yamazaki, Keizo Fujiwara, Saburo Moroto, Tomoko Yamazaki, Rinko Tamaya, Naoko Fujii, Shogo Shinohara
    • Organizer
      13th Asia Pacific Symposium on Cochlear Implants and Related Sciences
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Cortical network for speech reading in prelingually deafened children develops differently depending on their primary communication mode2021

    • Author(s)
      Yasushi Naito, Keizo Fujiwara, Hiroshi Yamazak, Sabro Moroto, Tomoko Yamazaki, Rinko Tamaya, Naoko Fujii, Shin-ichi Usami, Hideaki Moteki, Toshiko Mori
    • Organizer
      13th Asia Pacific Symposium on Cochlear Implants and Related Sciences
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 難聴・耳鳴の診断と対応2020

    • Author(s)
      内藤 泰、神崎 晶、高橋真理子
    • Organizer
      第121回日本耳鼻咽喉科学会・学術講演会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 小児人工内耳2020

    • Author(s)
      内藤 泰
    • Organizer
      第30回日本耳科学会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 小児における両側人工内耳の適応判断2020

    • Author(s)
      内藤 泰
    • Organizer
      第30回日本耳科学会
    • Related Report
      2020 Research-status Report
  • [Presentation] 蝸牛の解剖・病理所見から考える人工内耳電極アレーの形態と臨床2020

    • Author(s)
      内藤 泰
    • Organizer
      第65回日本聴覚医学会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 高度難聴と前庭機能2020

    • Author(s)
      内藤 泰
    • Organizer
      第79回日本めまい平衡医学会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] Brain function of cochlear implant users(講演)2020

    • Author(s)
      Naito Y
    • Organizer
      Grand Rounds Distinguished Speaker Series, Department of Otolaryngology-Head and Neck Surgery, UCLA, Los Angeles,
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 内耳奇形の診断と治療(学術講演)2019

    • Author(s)
      内藤 泰
    • Organizer
      第120回日本耳鼻咽喉科学会, 大阪
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 経乳突法で治療した側頭骨内髄膜脳瘤を伴う成人型特発性耳性髄液漏の1例2019

    • Author(s)
      水野敬介, 内藤 泰, 齊田浩二, 道田哲彦, 濱口清海, 竹林慎治, 藤原敬三, 篠原尚吾
    • Organizer
      第81回耳鼻咽喉科臨床学会, 名古屋市
    • Related Report
      2019 Research-status Report
  • [Presentation] 急性中耳炎と髄膜炎により人工内耳の摘出と再手術を行ったcommon cavity奇形例2019

    • Author(s)
      道田哲彦,内藤 泰, 篠原尚吾, 藤原敬三, 濱口清海, 齊田浩二, 水野敬介
    • Organizer
      第81回耳鼻咽喉科臨床学会, 名古屋市
    • Related Report
      2019 Research-status Report
  • [Presentation] Indication criterfia for child CI & current status (Workshop)2019

    • Author(s)
      Naito Y
    • Organizer
      Hearing implant workshop, Petersburg, Russia
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 外耳道腫瘤の検討 -診断に至る過程について-2019

    • Author(s)
      藤原敬三, 内藤 泰, 篠原尚吾, 竹林慎治, 濵口清海, 道田哲彦, 齊田浩二, 水野敬介, 戸部陽太
    • Organizer
      第192回日耳鼻兵庫県地方部会, 神戸市
    • Related Report
      2019 Research-status Report
  • [Presentation] 外科的切除を行った外耳道良性腫瘤の検討2019

    • Author(s)
      藤原敬三, 内藤 泰, 竹林慎治, 濵口清海, 道田哲彦, 水野敬介
    • Organizer
      第29回日本耳科学会, 山形市
    • Related Report
      2019 Research-status Report
  • [Presentation] 鼓室形成術の既往のない鼓膜真珠腫9症例2019

    • Author(s)
      水野敬介, 藤原敬三, 道田哲彦, 濵口清海, 竹林慎治, 内藤 泰
    • Organizer
      第29回日本耳科学会, 山形市
    • Related Report
      2019 Research-status Report
  • [Presentation] 人工内耳植込術を行った小児例における術前後の眼振所見の検討2019

    • Author(s)
      水野敬介, 内藤 泰, 船曳和雄, 濵口清海
    • Organizer
      第78回日本めまい平衡医学会, 富山市
    • Related Report
      2019 Research-status Report
  • [Presentation] AUDITORY IMPLANTS, Pediatric bilateral cochlear implant(特別企画, Chair/ Panelist)2019

    • Author(s)
      内藤 泰
    • Organizer
      第29回日本耳科学会, 山形市
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 人工聴覚器ワーキンググループ報告「人工聴覚器の適応拡大に向けて」)小児に対する人工内耳(1歳未満の人工内耳,両側 同時人工内耳)2019

    • Author(s)
      内藤 泰
    • Organizer
      第29回日本耳科学会, 山形市
    • Related Report
      2019 Research-status Report
  • [Presentation] 人工内耳の適応と検査:小児編(Education Program for Japanese 1 )2019

    • Author(s)
      内藤 泰
    • Organizer
      12th Asia Pacific Symposium on Cochlear Implants and Related Sciences (APSCI2019), Tokyo
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] First CI-induced maturation of rostral brainstem impairs 2nd CI outcomes in sequential bilateral CI2019

    • Author(s)
      Yamazaki H, Kishimoto I, Naito Y, Moroto S, Yamazaki T
    • Organizer
      12th Asia Pacific Symposium on Cochlear Implants and Related Sciences (APSCI2019), Tokyo
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Central Processing (Symposium, Moderator)2019

    • Author(s)
      Naito Y
    • Organizer
      12th Asia Pacific Symposium on Cochlear Implants and Related Sciences (APSCI2019), Tokyo
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Bilateral CI 1 (Symposium, Moderator)2019

    • Author(s)
      Naito Y
    • Organizer
      12th Asia Pacific Symposium on Cochlear Implants and Related Sciences (APSCI2019), Tokyo
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Sequential and simultaneous bilateral CI in children (Symposium / Presenter / Bilateral CI 1)2019

    • Author(s)
      Naito Y
    • Organizer
      12th Asia Pacific Symposium on Cochlear Implants and Related Sciences (APSCI2019), Tokyo
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 小児人工内耳の適応・リハビリテーションと長期経過(講演)2019

    • Author(s)
      内藤 泰
    • Organizer
      近畿ブロック身体障害者更生相談所長協議会, 神戸市
    • Related Report
      2019 Research-status Report
  • [Presentation] 人工内耳と難聴関連遺伝子について-遺伝子の仕組みを正しく理解する-(講演)2019

    • Author(s)
      内藤 泰
    • Organizer
      第25回難聴と人工内耳の勉強会, 神戸市
    • Related Report
      2019 Research-status Report
  • [Presentation] 小児内耳奇形例の人工内耳術後成績2019

    • Author(s)
      諸頭三郎, 山崎朋子, 玉谷輪子, 藤井直子, 藤原敬三, 戸部陽太, 内藤 泰
    • Organizer
      第64回日本聴覚医学会, 大阪市
    • Related Report
      2019 Research-status Report
  • [Presentation] 小児両側同時人工内耳症例の術後成績2019

    • Author(s)
      山崎朋子, 諸頭三郎,玉谷輪子, 藤井直子, 藤原敬三,内藤 泰
    • Organizer
      第64回日本聴覚医学会, 大阪市
    • Related Report
      2019 Research-status Report
  • [Presentation] 人工内耳術後のハビリテーション(教育セミナー)2019

    • Author(s)
      内藤 泰
    • Organizer
      第64回日本聴覚医学会, 大阪市
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 急性中耳炎と髄膜炎により人工内耳の摘出と再手術を行ったcommon cavity奇形例2019

    • Author(s)
      道田哲彦, 内藤 泰,篠原尚吾,藤原敬三,竹林慎治,濵口清海,齊田浩二,水野敬介
    • Organizer
      第191回日耳鼻兵庫県地方部会
    • Related Report
      2018 Research-status Report
  • [Presentation] 内耳奇形の治療2019

    • Author(s)
      内藤 泰
    • Organizer
      第120回日本耳鼻咽喉科学会総会・学術講演会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] めまいと難聴の画像診断と手術2018

    • Author(s)
      内藤 泰
    • Organizer
      愛知県耳鼻咽喉科医会三河地区研修会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 重度難聴治療における人工内耳の役割と将来像2018

    • Author(s)
      内藤 泰
    • Organizer
      第119回日本耳鼻咽喉科学会総会・学術講演会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Bilateral CI in children2018

    • Author(s)
      Naito Y
    • Organizer
      Auditory implant workshop in Osaka 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 良聴耳聴力レベルが 70dB 以上 90dB 未満の成人人工内耳症例の検討2018

    • Author(s)
      藤井直子,諸頭三郎,山崎朋子,玉谷輪子,藤原敬三,内藤 泰
    • Organizer
      第63回日本聴覚医学会総会・学術講演会
    • Related Report
      2018 Research-status Report
  • [Presentation] 両側人工内耳装用児の方向感機能について2018

    • Author(s)
      山崎朋子,諸頭三郎,玉谷輪子,藤井直子,藤原敬三,内藤 泰
    • Organizer
      第63回日本聴覚医学会・学術講演会
    • Related Report
      2018 Research-status Report
  • [Presentation] 両側小耳症と外耳道閉鎖症を合併した伝音難聴 2 例に対する 人工中耳の留意点と術後成績2018

    • Author(s)
      玉谷輪子,山崎朋子,藤井直子,諸頭三郎,藤原敬三,内藤 泰
    • Organizer
      第63回日本聴覚医学会・学術講演会
    • Related Report
      2018 Research-status Report
  • [Presentation] ACTG1 遺伝子変異による難聴症例の検討2018

    • Author(s)
      宮嶋宏樹,茂木英明,北尻真一郎,西尾信哉,村田考啓,池園哲郎, 武田英彦,阿部聡子,岩崎聡,高橋優宏,内藤 泰,山崎博司,神田幸彦,宇佐美真一
    • Organizer
      第63回日本聴覚医学会・学術講演会
    • Related Report
      2018 Research-status Report
  • [Presentation] 先天性難聴を有する同胞間で原因遺伝子が異なる症例2018

    • Author(s)
      道田哲彦,内藤泰,藤原敬三,宇佐美真一
    • Organizer
      第63回日本聴覚医学会・学術講演会
    • Related Report
      2018 Research-status Report
  • [Book] 高度難聴(補聴器、人工内耳):今日の治療指針2020年度,福井次夫,高木 誠 編, 医学書院, 第1版, 東京, 1614-1615, 2020年2020

    • Author(s)
      内藤 泰
    • Total Pages
      1472
    • Publisher
      医学書院,
    • ISBN
      9784524226573
    • Related Report
      2019 Research-status Report
  • [Book] より低侵襲で明瞭な聞こえが期待される新型人工内耳が登場:週刊朝日MOOK手術でわかるいい病院2020

    • Author(s)
      内藤 泰
    • Total Pages
      572
    • Publisher
      朝日新聞出版
    • ISBN
      9784022775672
    • Related Report
      2019 Research-status Report
  • [Book] 週刊朝日MOOK「よく聞こえない」ときの耳の本 「「人工内耳」は、聴こえを取り戻す有力な治療選択肢です」2018

    • Author(s)
      小川 郁(監修)、内藤 泰(分担執筆)
    • Total Pages
      110
    • Publisher
      朝日新聞出版
    • ISBN
      9784022775474
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2023-01-30  

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