| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Diabetic retinopathy (DR) is a retinal microvascular complication of diabetes and is still a leading cause of visual impairment in the developed countries. Previous studies revealed that retinal glial cell migration is involved in the fibrovascular tissue formation, leading to the severe complications in patients with DR; however, the detailed mechanisms remains unclear.
Acrolein is a highly reactive unsaturated aldehyde that causes dysfunction of multiple proteins. In this study, we explored the regulatory mechanisms responsible for retinal glial cell migration induced by unsaturated aldehyde acrolein and found that i) acrolein exerted potent cellular toxicity at a high concentration; however, sublethal concentration of acrolein slightly induces viability and migratory property of retinal glial cells; and ii) inflammatory chemokine CXCL1 is a mediator of glial cell migration induced by acrolein.
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