Straegies to save the lifetime patients' QOL from glaucoma.
Project/Area Number |
18K09399
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 56060:Ophthalmology-related
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Research Institution | Niigata University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
長谷部 日 新潟大学, 医歯学総合病院, 講師 (30535167)
栂野 哲哉 新潟大学, 医歯学系, 助教 (70568550)
松岡 尚気 新潟大学, 医歯学系, 助教 (70646265)
寺島 浩子 新潟大学, 医歯学総合病院, 講師 (90721720)
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Project Period (FY) |
2018-04-01 – 2022-03-31
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Project Status |
Completed (Fiscal Year 2021)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2019: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2018: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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Keywords | 緑内障 / Quality of life(QOL) / ハンフリー視野 / VFQ-25 Raschスコア / 光干渉断層計(OCT) / 網膜神経線維層 / OCT血管造影 / 黄斑部毛細血管網 / 緑内障性視神経症 / 視野 / QOL(quality of life) / OCTアンギオグラフィー(OCTA) / NEI VFQ-25 / コントラスト感度 / トラベクレクトミー / ドライビングシミュレータ / 前視野緑内障 / OCTアンギオグラフィー / QOL |
Outline of Final Research Achievements |
1) In order to evaluate the visual QOL, the results of the questionnaire VFQ-25 were converted into Rasch scores, and it was reported that the binocular HFA24-2 / 10-2 visual field superimposition visual field score of glaucoma patients strongly correlates with QOL. 2) From the central 10°visual field (function) and OCT findings (morphology) of glaucoma patients, the visual field and fundus region necessary for maintaining vision were identified. 3) Using OCT Angiography (OCTA), we reported a decrease in the capillary network around the optic nerve papilla in the broad sense POAG eye and a decrease in the blood density (FD, flow density) in the luteal spot. In glaucoma eyes, the central fossa avascular region (FAZ) was enlarged and deformed, and it was reported that it was strongly associated with luteal visual impairment.
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Academic Significance and Societal Importance of the Research Achievements |
この研究は緑内障患者の視覚的QOLを生涯にわたって守るための治療と管理のスタラテジー構築のための基礎的研究となった.両眼重ね合わせ視野を用いた視野スコアはQOLとその経時的の評価の指標となる可能性が高い.また、視力維持に必要な眼底と視野の領域を検出したことは、視力低下のリスク評価にとって重要で、重症度判定の一つの基準になると考えられる.新しい臨床検査のひとつであるOCTAによって、緑内障の中心窩障害と進行のリスクを評価できる可能性があり、個別化治療の指標となりうると考えられた.超高齢化社会を迎えている日本の緑内障患者のQOL予後の改善に貢献することが期待できる.
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Report
(5 results)
Research Products
(48 results)
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[Journal Article] Prediction of causative genes in inherited retinal disorder from fundus photography and autofluorescence imaging using deep learning techniques.2021
Author(s)
Fujinami-Yokokawa Y, Ninomiya H, Liu X, Yang L, Pontikos N, Yoshitake K, Iwata T, Sato Y, Hashimoto T, Tsunoda K, Miyata H, Fujinami K; Japan Eye Genetics Study (JEGC) Group.
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Journal Title
Br J Ophthalmol
Volume: -
Issue: 9
Pages: 1272-1279
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Spatial and Temporal Relationship between Structural Progression and Disc Hemorrhage in Glaucoma in a 3-Year Prospective Study.2020
Author(s)
Higashide T, Ohkubo S, Udagawa S, Sugiyama K, Tanihara H, Araie M, Tomita G, Matsumoto C, Fukuchi T, Tomidokoro A, Hangai M, Kawata H, Inai M, Tanaka Y; SVF Prospector Study Group.
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Journal Title
Ophthalmol Glaucoma.
Volume: ー
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Clinical and Genetic Characteristics of 18 Patients from 13 Japanese Families with CRX-associated retinal disorder: Identification of Genotype-phenotype Association2020
Author(s)
Fujinami-Yokokawa Y, Fujinami K, Kuniyoshi K, Hayashi T, Ueno S, Mizota A, Shinoda K, Arno G, Pontikos N, Yang L, Liu X, Sakuramoto H, Katagiri S, Mizobuchi K, Kominami T, Terasaki H, Nakamura N, Kameya S, Yoshitake K, Miyake Y, Kurihara T, Tsubota K, Miyata H, Iwata T, Tsunoda K; Japan Eye Genetics Consortium.
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Journal Title
Sci Rep
Volume: 12
Issue: 1
Pages: 9531-9531
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Intraoperative intraocular pressure changes during robot-assisted radical prostatectomy: associations with perioperative and clinicopathological factors.2020
Author(s)
Shirono Y, Takizawa I, Kasahara T, Maruyama R, Yamana K, Tanikawa T, Hara N, Sakaue Y, Togano T, Nishiyama T, Fukuchi T, Tomita Y.
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Journal Title
BMC Urol.
Volume: 20(1)
Issue: 1
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Genetic Spectrum of EYS-associated Retinal Disease in a Large Japanese Cohort: Identification of Disease-associated Variants with Relatively High Allele Frequency.2020
Author(s)
Yang L, Fujinami K, Ueno S, Kuniyoshi K, Hayashi T, Kondo M, Mizota A, Naoi N, Shinoda K, Kameya S, Fujinami-Yokokawa Y, Liu X, Arno G, Pontikos N, Kominami T, Terasaki H, Sakuramoto H, Katagiri S, Mizobuchi K, Nakamura N, Mawatari G, Kurihara T, Tsubota K, Miyake Y, Yoshitake K, Iwata T, Tsunoda K; JEGC study group.
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Journal Title
Sci Rep.
Volume: 10
Issue: 1
Pages: 1-10
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] The effect of concentric constriction of the visual field to 10 and 15 degrees on simulated motor vehicle accidents.2018
Author(s)
Udagawa S, Ohkubo S, Iwase A, Susuki Y, Kunimatsu-Sanuki S, Fukuchi T, Matsumoto C, Ohno Y, Ono H, Sugiyama K, Araie M.
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Journal Title
PLoS One.
Volume: 13(3)
Issue: 3
Pages: e0193767-e0193767
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Presentation] Clustered Visual Field Progression of Primary Open-angle Glaucoma with Disc Hemorrhages in a Three-year Prospective Study, 2nd report.2019
Author(s)
Takeo Fukuchi, Tetsuya Togano, Hidenobu Tanihara, Makoto Araie, Shinji Ohkubo, Tomomi Higashide, Kazuhisa Sugiyama, Goji Tomita, Chota Matsumoto, Atsuo Tomidokoro, Masanori Hangai, Hisashi Kawata, Hiroshi Inoue, Maya Inai, Yuki Tanaka.
Organizer
American Academy of Ophthalmology 2019
Related Report
Int'l Joint Research
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[Presentation] Clustered Visual Field Progression of Primary Open-angle Glaucoma with Disc Hemorrhages in a Three-year Prospective Study.2018
Author(s)
Takeo Fukuchi MD, Testuya Togano MD, PhD, Hidenobu Tanihara MD PhD, Makoto Araie MD, Goji Tomita MD, Chota Matsumoto MD, Shinji Ohkubo MD PhD, Atsuo Tomidokoro MD, Masanori Hangai MD, Kazuhisa Sugiyama, MD, PHD, Hisashi Kawata
Organizer
AAO
Related Report
Int'l Joint Research
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[Presentation] 緑内障の構造・視野に関する前向き観察研究におけるクラスタ別視野進行と乳頭出血2018
Author(s)
福地健郎, 栂野哲哉, 谷原秀信, 東出朋巳, 大久保真司, 宇田川さち子, 杉山和久, 新家眞,冨田剛司, 松本長太, 富所敦男, 板谷正紀
Organizer
第72回日本臨床眼科学会
Related Report
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