Straegies to save the lifetime patients' QOL from glaucoma.

• Project/Area Number: 18K09399
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56060:Ophthalmology-related
• Research Institution: Niigata University
• Principal Investigator: 福地 健郎 新潟大学, 医歯学系, 教授 (90240770)
• Co-Investigator(Kenkyū-buntansha): 長谷部 日 新潟大学, 医歯学総合病院, 講師 (30535167) ; 栂野 哲哉 新潟大学, 医歯学系, 助教 (70568550) ; 松岡 尚気 新潟大学, 医歯学系, 助教 (70646265) ; 寺島 浩子 新潟大学, 医歯学総合病院, 講師 (90721720)
• Project Period (FY): 2018-04-01 – 2022-03-31
• Project Status: Granted (Fiscal Year 2020)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2020: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2019: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000); Fiscal Year 2018: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
• Keywords: 緑内障性視神経症 / 視野 / QOL（quality of life） / 光干渉断層計（OCT） / OCTアンギオグラフィー（OCTA） / NEI VFQ-25 / コントラスト感度 / トラベクレクトミー / ドライビングシミュレータ / 前視野緑内障 / OCTアンギオグラフィー / 緑内障 / QOL

Outline of Annual Research Achievements

１．原発開放隅角緑内障（POAG）広義の視野障害とQOL、VFQ-25ラシュスコアと視野の加重平均感度法を用いて、最もQOLに関連する領域は中心やや下方視野であること、遠見や近見、運転、全体的見え方、一般的健康感などのQOLの下位尺度（項目）毎に最も重要な視野の領域が異なる可能性について明らかにした．
２．POAG広義における黄斑部障害・中心窩障害、１）視力維持に必要な黄斑部の領域、中心10°内視野の領域を特定した．緑内障患者の中心窩閾値は矯正視力と高い相関を示すこと、乳頭黄斑領域の網膜神経線維層および視野が保たれている症例の視力と中心窩閾値が維持されていることを明らかにした．２）OCTアンギオグラフィー（OCTA）によって、緑内障患者の形態（網膜内層厚）、機能（視野）と微少血管構築の関連について検証した．中心窩無血管領域（FAZ)、乳頭深部微少血管脱落（MvD）が中心10度内視野、中心窩閾値と強く関連することが明らかとなった．黄斑部血管密度が低い症例では中心10度内視野の進行が速やかである可能性があることが明らかになった．
３．POAG広義患者のコントラスト感度とQOL：POAG広義では視野障害の進行に伴ってコントラスト感度が低下することを明らかにした．また、視野のworse eyeのコントラスト感度がQOLスコアと高く相関することを示した．コントラスト感度検査が緑内障患者のQOL判定に重要な検査になる可能性を示した．
４．乳頭黄斑領域障害を伴うPOAG広義眼に対するトラベクレクトミーによって、眼圧は低下し、平均として中心10°内視野障害の進行は緩徐化した．しかし、眼圧が下降したにもかかわらず、視力、中心窩閾値が低下する症例、乳頭中心窩領域の感度低下がむしろ加速する症例が見られた．さらに検討を要する．

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

計画された研究課題について、研究計画、データ収集、学会発表を含めて順調に進展しており、総合して第72回日本臨床眼科学会・特別講演で発表した．現在、個々の研究内容について論文化を進めている．コントラスト感度と視野障害、QOLとの関連、OCTAによる乳頭周囲深部血管網と視力、中心10度内視野との関連など、当初の研究計画からさらに発展した課題が加わっている．一部に新型コロナウイルス感染症の影響による受診患者の減少に伴ってデータ収集がやや遅れているテーマがある．引き続き研究を継続中である．

Strategy for Future Research Activity

研究および発表済みデータの論文化を急ぐ．
研究継続中の課題に関しては、積極的な症例収集と、複数回の撮影で画像の質を担保し、解析を急ぐ．緑内障治療による視機能およびQOLの維持効果についての分析をさらに進める．

Research Products

• [Journal Article] Iridocorneal contact as a potential cause of corneal decompensation following laser peripheral iridotomy. (2021)
  • Author(s): Imai K, Sawada H, Hatase T, Fukuchi T.
  • Journal Title: Jpn J Ophthalmol. Volume: ー Pages: ー
  • DOI: 10.1007/s10384-021-00830-y.
  • Peer Reviewed / Open Access
• [Journal Article] Optical coherence tomography angiography and Humphrey field analyser for macular capillary non-perfusion evaluation in branch retinal vein occlusion. (2021)
  • Author(s): Terashima H, Okamoto F, Hasebe H, Ueda E, Yoshida H, Fukuchi T.
  • Journal Title: Sci Rep. Volume: 25 Pages: 4583
  • DOI: 10.1038/s41598-021-84240-7
  • Peer Reviewed / Open Access
• [Journal Article] Efficient measurements for the dynamic range of human lightness perception. (2021)
  • Author(s): Horiguchi H, Suzuki E, Kubo H, Fujikado T, Asonuma S, Fujimoto C, Tatsumoto M, Fukuchi T, Sakaue Y, Ichimura M, Kurimoto Y, Yamamoto M, Nakadomari S.
  • Journal Title: Jpn J Ophthalmol. Volume: ー Pages: ー
  • DOI: 10.1007/s10384-020-00808-2.
  • Peer Reviewed / Open Access
• [Journal Article] The occurrence of optic disc haemorrhage in primary open-angle glaucoma eyes with lower normal pressure and its relating factors. (2021)
  • Author(s): Sakata R, Yoshitomi T, Araie M; for Lower Normal Pressure Glaucoma Study Members in Japan Glaucoma Society.
  • Journal Title: Acta Ophthalmol. Volume: 99 Pages: e28-e35
  • DOI: 10.1111/aos.14506.
  • Peer Reviewed / Open Access
• [Journal Article] 2つの視野計による新しい視野障害等級判定 緑内障による検討 (2021)
  • Author(s): 石井 雅子, 間 聡美, 末武 亜紀, 福地 健郎
  • Journal Title: あたらしい眼科 Volume: 38 Pages: 97-101
  • Peer Reviewed
• [Journal Article] Relationship between morphological changes in the foveal avascular zone of the epiretinal membrane and postoperative visual function. (2020)
  • Author(s): Yoshida H, Terashima H, Ueda E, Hasebe H, Matsuoka N, Nakano H, Fukuchi T.
  • Journal Title: BMJ Open Ophthalmol. Volume: 17 Pages: ー
  • DOI: 10.1136/bmjophth-2020-000636.
  • Peer Reviewed / Open Access
• [Journal Article] Choroid structure analysis following initiation of hemodialysis by using swept-source optical coherence tomography in patients with and without diabetes. (2020)
  • Author(s): Nakano H, Hasebe H, Murakami K, Cho H, Kondo D, Iino N, Fukuchi T.
  • Journal Title: PLoS One. Volume: 11 Pages: ー
  • DOI: 10.1371/journal.pone.0239072.
  • Peer Reviewed / Open Access
• [Journal Article] Spatial and Temporal Relationship between Structural Progression and Disc Hemorrhage in Glaucoma in a 3-Year Prospective Study. (2020)
  • Author(s): Higashide T, Ohkubo S, Udagawa S, Sugiyama K, Tanihara H, Araie M, Tomita G, Matsumoto C, Fukuchi T, Tomidokoro A, Hangai M, Kawata H, Inai M, Tanaka Y; SVF Prospector Study Group.
  • Journal Title: Ophthalmol Glaucoma. Volume: ー Pages: ー
  • DOI: 10.1016/j.ogla.2020.08.008.
  • Peer Reviewed / Open Access
• [Journal Article] Clinical Features of Patients with Exfoliation Glaucoma Requiring Surgical Intervention. (2020)
  • Author(s): Nakano H, Togano T, Sakaue Y, Suetaka A, Iikawa R, Nakano R, Fukuchi T.
  • Journal Title: J Ophthalmol. Volume: ー Pages: ー
  • DOI: 10.1155/2020/9423756.
  • Peer Reviewed / Open Access
• [Journal Article] Foveal Avascular Zone Measurement Via Optical Coherence Tomography Angiography and its Relationship With the Visual Field in Eyes With Open-angle Glaucoma. (2020)
  • Author(s): Igarashi R, Ochiai S, Togano T, Sakaue Y, Suetake A, Iikawa R, Honma Y, Miyamoto D, Fukuchi T.
  • Journal Title: J Glaucoma. Volume: 29 Pages: 492-497
  • DOI: 10.1097/IJG.0000000000001492.
  • Peer Reviewed / Open Access
• [Journal Article] What is glaucomatous optic neuropathy? (2020)
  • Author(s): Nakazawa T, Fukuchi T.
  • Journal Title: Jpn J Ophthalmol. Volume: 64 Pages: 243-249
  • DOI: 10.1007/s10384-020-00736-1.
  • Peer Reviewed / Open Access
• [Journal Article] Clinical and Genetic Characteristics of 18 Patients from 13 Japanese Families with CRX-associated retinal disorder: Identification of Genotype- phenotype Association. (2020)
  • Author(s): Fujinami-Yokokawa Y, Fujinami K, Kuniyoshi K, Hayashi T, Ueno S, Mizota A, Shinoda K, Arno G, Pontikos N, Yang L, Liu X, Sakuramoto H, Katagiri S, Mizobuchi K, Kominami T, Terasaki H, Nakamura N, Kameya S, Yoshitake K, Miyake Y, Kurihara T, Tsubota K, Miyata H, Iwata T, Tsunoda K; Japan Eye Genetics Consortium.
  • Journal Title: Sci Rep. Volume: 12 Pages: 9531
  • DOI: 10.1038/s41598-020-65737-z
  • Peer Reviewed / Open Access
• [Journal Article] Prediction of causative genes in inherited retinal disorder from fundus photography and autofluorescence imaging using deep learning techniques. (2020)
  • Author(s): Fujinami-Yokokawa Y, Ninomiya H, Liu X, Yang L, Pontikos N, Yoshitake K, Iwata T, Sato Y, Hashimoto T, Tsunoda K, Miyata H, Fujinami K; Japan Eye Genetics Study (JEGC) Group
  • Journal Title: Br J Ophthalmol. Volume: ー Pages: ー
  • DOI: 10.1136/bjophthalmol-2020-318544.
  • Peer Reviewed / Open Access
• [Journal Article] Intraocular pressure-lowering effects of ripasudil in uveitic glaucoma, exfoliation glaucoma, and steroid-induced glaucoma patients: ROCK-S, a multicentre historical cohort study. (2020)
  • Author(s): Futakuchi A, Morimoto T, Ikeda Y, Tanihara H, Inoue T; ROCK-S study group collaborators.
  • Journal Title: Sci Rep. Volume: 10 Pages: ー
  • DOI: 10.1038/s41598-020-66928-4.
  • Peer Reviewed / Open Access
• [Journal Article] 視線解析装置を用いた緑内障患者の黙読評価 (2020)
  • Author(s): 村田 憲章, 宮本 大輝, 栂野 哲哉, 福地 健郎
  • Journal Title: 日本ロービジョン学会誌 Volume: 20 Pages: 43-49
  • Peer Reviewed
• [Journal Article] Gemcitabine induces Parkin-independent mitophagy through mitochondrial-resident E3 ligase MUL1-mediated stabilization of PINK1. (2020)
  • Author(s): Igarashi R, Yamashita SI, Yamashita T, Inoue K, Fukuda T, Fukuchi T, Kanki T.
  • Journal Title: Sci Rep. Volume: 10(1) Pages: -
  • DOI: 10.1038/s41598-020-58315-w.
  • Peer Reviewed / Open Access
• [Journal Article] Estimation of the central 10-degree visual field using en-face images obtained by optical coherence tomography. (2020)
  • Author(s): Iikawa R, Togano T, Sakaue Y, Suetake A, Igarashi R, Miyamoto D, Yaoeda K, Seki M, Fukuchi T.
  • Journal Title: PLoS One. Volume: 15(3) Pages: -
  • DOI: 10.1371/journal.pone.0229867.
  • Peer Reviewed / Open Access
• [Journal Article] Intraoperative intraocular pressure changes during robot-assisted radical prostatectomy: associations with perioperative and clinicopathological factors. (2020)
  • Author(s): Shirono Y, Takizawa I, Kasahara T, Maruyama R, Yamana K, Tanikawa T, Hara N, Sakaue Y, Togano T, Nishiyama T, Fukuchi T, Tomita Y.
  • Journal Title: BMC Urol. Volume: 20(1) Pages: -
  • DOI: 10.1186/s12894-020-00595-5.
  • Peer Reviewed / Open Access
• [Journal Article] Foveal Avascular Zone Measurement Via Optical Coherence Tomography Angiography and its Relationship with the Visual Field in Eyes with Open-angle Glaucoma. (2020)
  • Author(s): Igarashi R, Ochiai S, Togano T, Sakaue Y, Suetake A, Iikawa R, Honma Y, Miyamoto D, Fukuchi T.
  • Journal Title: J Glaucoma. Volume: - Pages: -
  • DOI: 10.1097/IJG.0000000000001492.
  • Peer Reviewed / Open Access
• [Journal Article] Genetic Spectrum of EYS-associated Retinal Disease in a Large Japanese Cohort: Identification of Disease-associated Variants with Relatively High Allele Frequency. (2020)
  • Author(s): Yang L, Fujinami K, Ueno S, Kuniyoshi K, Hayashi T, Kondo M, Mizota A, Naoi N, Shinoda K, Kameya S, Fujinami-Yokokawa Y, Liu X, Arno G, Pontikos N, Kominami T, Terasaki H, Sakuramoto H, Katagiri S, Mizobuchi K, Nakamura N, Mawatari G, Kurihara T, Tsubota K, Miyake Y, Yoshitake K, Iwata T, Tsunoda K; JEGC study group.
  • Journal Title: Sci Rep. Volume: 10(1) Pages: -
  • DOI: 10.1038/s41598-020-62119-3.
  • Peer Reviewed / Open Access
• [Journal Article] Glaucoma-Associated Mutations in the Optineurin Gene Have Limited Impact on Parkin-Dependent Mitophagy. (2019)
  • Author(s): Chernyshova K, Inoue K, Yamashita SI, Fukuchi T, Kanki T.
  • Journal Title: Invest Ophthalmol Vis Sci. Volume: 60(10) Pages: 3625-3635
  • DOI: 10.1167/iovs.19-27184.
  • Peer Reviewed / Open Access
• [Journal Article] The natural course of IgG4-related ophthalmic disease after debulking surgery: a single-centre retrospective study. (2019)
  • Author(s): Ominato J, Oyama T, Cho H, Shiozaki N, Umezu H, Takizawa J, Fukuchi T.
  • Journal Title: BMJ Open Ophthalmol. Volume: 4(1) Pages: -
  • DOI: 10.1136/bmjophth-2019-000295.
  • Peer Reviewed / Open Access
• [Journal Article] Vision-related quality of life in Japanese patients with wet age-related macular degeneration treated with intravitreal aflibercept in a real-world setting. (2019)
  • Author(s): Gomi F, Migita H, Sakaguchi T, Okada H, Sugawara T, Hikichi Y; Participating Investigators.
  • Journal Title: Jpn J Ophthalmol. Volume: 63(6) Pages: -
  • DOI: 10.1007/s10384-019-00687-2.
  • Peer Reviewed / Open Access
• [Journal Article] Evaluation of deep convolutional neural networks for glaucoma detection. (2019)
  • Author(s): Phan S, Satoh S, Yoda Y, Kashiwagi K, Oshika T, Japan Ocular Imaging Registry Research Group.
  • Journal Title: Jpn J Ophthalmol. Volume: Feb 24 Pages: -
  • DOI: 10.1007/s10384-019-00659-6.
  • Peer Reviewed / Open Access
• [Journal Article] Ocular hypotensive effects of prostaglandin analogs in Japanese patients with normal-tension glaucoma: a literature review. (2018)
  • Author(s): Takagi Y, Santo K, Hashimoto M, Fukuchi T.
  • Journal Title: Clin Ophthalmol. Volume: 12 Pages: 1837-1844
  • DOI: 10.2147/OPTH.S166657.
  • Peer Reviewed / Open Access
• [Journal Article] Factors associated with fluctuations in repeated measurements of intraocular pressure using the Goldmann applanation tonometer in Japanese patients with primary open-angle glaucoma. (2018)
  • Author(s): Yaoeda K, Fukushima A, Shirakashi M, Miki A, Fukuchi T.
  • Journal Title: Clin Ophthalmol Volume: 12 Pages: 1473-1478
  • DOI: 10.2147/OPTH.S174277.
  • Peer Reviewed / Open Access
• [Journal Article] The effect of concentric constriction of the visual field to 10 and 15 degrees on simulated motor vehicle accidents. (2018)
  • Author(s): Udagawa S, Ohkubo S, Iwase A, Susuki Y, Kunimatsu-Sanuki S, Fukuchi T, Matsumoto C, Ohno Y, Ono H, Sugiyama K, Araie M.
  • Journal Title: PLoS One. Volume: 13(3) Pages: -
  • DOI: 10.1371/journal.pone.0193767.
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy of predetermined therapeutic measures against bleb-related infection in the (2018)
  • Author(s): Shoji N, Arakaki Y, Nakamoto K, Yamamoto T, Kuwayama Y; Collaborative Bleb-related Infection Incidence and Treatment Study Group.
  • Journal Title: Acta Ophthalmol. Volume: 96(2) Pages: e229-e236
  • DOI: 10.1111/aos.13523.
  • Peer Reviewed / Open Access
• [Journal Article] 緑内障とquality of vision/quality of life (2018)
  • Author(s): 福地 健郎
  • Journal Title: 日本眼科学会雑誌 Volume: 122(10) Pages: 801-814
  • Peer Reviewed
• [Journal Article] PPGの診断と治療の考え方 (2018)
  • Author(s): 福地 健郎, 相澤 奈帆子, 溝上 志朗, 澤田 明
  • Journal Title: Frontiers in Glaucoma Volume: 55 Pages: 27-37
  • Peer Reviewed
• [Presentation] 緑内障からQOLを守るためのストラテジー －EBMからPCMへ－ (2020)
  • Author(s): 福地健郎
  • Organizer: 第74回日本臨床眼科学会
  • Invited
• [Presentation] 測定値間の因果関係を考慮した隅角形態モデリング (2020)
  • Author(s): 栂野哲哉、五十嵐遼子、間聡美、末武亜紀、坂上悠太、田沢綾子、飯川龍、福地健郎
  • Organizer: 第31回日本緑内障学会
• [Presentation] Effect of internal limiting membrane peeling on macular visual function in patients with vitrectomy for epiretinal membrane in glaucomatous eyes (2020)
  • Author(s): Hiroko Terashima, Hiruma Hasebe, Eriko Ueda, Hiromitsu Yoshida, Tetsuya Togano, Takeo Fukuchi
  • Organizer: Euretina 2020
  • Int'l Joint Research
• [Presentation] 前視野緑内障の診断と治療 (2019)
  • Author(s): 福地健郎
  • Organizer: 第123回日本眼科学会総会
• [Presentation] 新規ブリモニジン／チモロール配合点眼剤の第III 相長期投与試験 (2019)
  • Author(s): 福地健郎、新家眞、関弥卓郎
  • Organizer: 第73回日本臨床眼科学会
• [Presentation] Clustered Visual Field Progression of Primary Open-angle Glaucoma with Disc Hemorrhages in a Three-year Prospective Study, 2nd report. (2019)
  • Author(s): Takeo Fukuchi, Tetsuya Togano, Hidenobu Tanihara, Makoto Araie, Shinji Ohkubo, Tomomi Higashide, Kazuhisa Sugiyama, Goji Tomita, Chota Matsumoto, Atsuo Tomidokoro, Masanori Hangai, Hisashi Kawata, Hiroshi Inoue, Maya Inai, Yuki Tanaka.
  • Organizer: American Academy of Ophthalmology 2019
  • Int'l Joint Research
• [Presentation] Clustered Visual Field Progression of Primary Open-angle Glaucoma with Disc Hemorrhages in a Three-year Prospective Study. (2018)
  • Author(s): Takeo Fukuchi MD, Testuya Togano MD, PhD, Hidenobu Tanihara MD PhD, Makoto Araie MD, Goji Tomita MD, Chota Matsumoto MD, Shinji Ohkubo MD PhD, Atsuo Tomidokoro MD, Masanori Hangai MD, Kazuhisa Sugiyama, MD, PHD, Hisashi Kawata
  • Organizer: AAO
  • Int'l Joint Research
• [Presentation] Correlation Among Foveal Avascular Zone (FAZ) Detected by OCT Angiography and Inner Retinal Thickness, and Visual Filed Defects in POAG/NTG patients. (2018)
  • Author(s): Takeo Fukuchi, Ryoko Igarashi, Shun Ochiai, Tetsuya Togano, Yuta sakaue, Iikawa Ryu, Suetake Aki.
  • Organizer: EGS
  • Int'l Joint Research
• [Presentation] 緑内障の構造・視野に関する前向き観察研究におけるクラスタ別視野進行と乳頭出血 (2018)
  • Author(s): 福地健郎, 栂野哲哉, 谷原秀信, 東出朋巳, 大久保真司, 宇田川さち子, 杉山和久, 新家眞,冨田剛司, 松本長太, 富所敦男, 板谷正紀
  • Organizer: 第72回日本臨床眼科学会
• [Presentation] ハンフリー視野測定と進行判定 (2018)
  • Author(s): 福地健郎
  • Organizer: 第7回日本視野学会
  • Invited