Straegies to save the lifetime patients' QOL from glaucoma.

• Project/Area Number: 18K09399
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56060:Ophthalmology-related
• Research Institution: Niigata University
• Principal Investigator: 福地 健郎 新潟大学, 医歯学系, 教授 (90240770)
• Co-Investigator(Kenkyū-buntansha): 長谷部 日 新潟大学, 医歯学総合病院, 講師 (30535167) ; 栂野 哲哉 新潟大学, 医歯学系, 助教 (70568550) ; 松岡 尚気 新潟大学, 医歯学系, 助教 (70646265)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Granted (Fiscal Year 2019)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2020: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2019: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000); Fiscal Year 2018: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
• Keywords: 緑内障性視神経症 / 視野 / QOL（quality of life） / 光干渉断層計（OCT） / OCTアンギオグラフィー（OCTA） / NEI VFQ-25 / ドライビングシミュレータ / 前視野緑内障 / OCTアンギオグラフィー / 緑内障 / QOL

Outline of Annual Research Achievements

１，OCTと視野、つまり形態と機能の両面から緑内障眼を管理し、QOLに直結する視力および中心視野を維持するための新しい経過観察と治療の方法を確立する．中心10度内視野検査とOCTにおける視力に最も関わる領域を特定し、形態、機能の両面からこの領域が障害された症例と障害されていない症例による視力、中心窩閾値について検討した．また緑内障治療によって視力が維持される可能性について検討中である．
２，視野検査結果からQOLを的確に推定、経時的にモニターする視野スコアを開発し、新たな重症度判定の方法を確立する．左右眼の中心30°内視野、中心10°内視野を複合させて高細密両眼重ね合わせ視野を作成、さらにスコア化し、QOLスコアとの相関を検証中である．また緑内障患者のコントラスト感度、さらにQOLとの関連について検討中である．病期と視野障害の領域、程度との関連について明らかにする予定である．
３，OCTアンギオグラフィー（OCTA）によって、緑内障患者の形態（網膜内層厚）、機能（視野）と微少血管構築の関連について検証中である．中心窩無血管領域（FAZ)、乳頭深部微少血管脱落（MvD）が中心10度内視野、中心窩閾値と強く関連することが明らかとなった．また、黄斑部血管密度が小さいほど中心10度内視野の進行が速やかである可能性があることが明らかになった．
４，ヘッドマウント型視野計アイモACを用いて通常の片眼遮蔽と両眼開放では視野測定結果が異なる事を明らかにした．による測定結果の違い、視線解析装置と緑内障患者用ドライビングシミュレータを用いて、緑内障患者の視野障害と運転能力の関連について検証中である．

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

計画されたそれぞれの研究課題については研究計画、データ収集、学会発表を含めて順調に進展している．既発表データに関する論文化がやや遅れている．コントラスト感度、OCTAによる黄斑部血管構築と中心10度内視野との関連など、当初の研究計画からさらに派生した重要な課題が加わってきている．総合的に当初の研究目的に近づいている．

Strategy for Future Research Activity

研究済データの論文化を急ぐ．
研究継続中の課題に関しては、積極的な症例収集と、複数回の撮影で画像の質を担保し、解析を急ぐ．緑内障治療による視機能およびQOLの維持効果についての分析をさらに進める．

Research Products

• [Journal Article] Gemcitabine induces Parkin-independent mitophagy through mitochondrial-resident E3 ligase MUL1-mediated stabilization of PINK1. (2020)
  • Author(s): Igarashi R, Yamashita SI, Yamashita T, Inoue K, Fukuda T, Fukuchi T, Kanki T.
  • Journal Title: Sci Rep. Volume: 10(1) Issue: 1 Pages: 1-11
  • DOI: 10.1038/s41598-020-58315-w
  • Peer Reviewed / Open Access
• [Journal Article] Estimation of the central 10-degree visual field using en-face images obtained by optical coherence tomography. (2020)
  • Author(s): Iikawa R, Togano T, Sakaue Y, Suetake A, Igarashi R, Miyamoto D, Yaoeda K, Seki M, Fukuchi T.
  • Journal Title: PLoS One. Volume: 15(3)
  • DOI: 10.1371/journal.pone.0229867
  • Peer Reviewed / Open Access
• [Journal Article] Intraoperative intraocular pressure changes during robot-assisted radical prostatectomy: associations with perioperative and clinicopathological factors. (2020)
  • Author(s): Shirono Y, Takizawa I, Kasahara T, Maruyama R, Yamana K, Tanikawa T, Hara N, Sakaue Y, Togano T, Nishiyama T, Fukuchi T, Tomita Y.
  • Journal Title: BMC Urol. Volume: 20(1)
  • DOI: 10.1186/s12894-020-00595-5
  • Peer Reviewed / Open Access
• [Journal Article] Foveal Avascular Zone Measurement Via Optical Coherence Tomography Angiography and its Relationship with the Visual Field in Eyes with Open-angle Glaucoma. (2020)
  • Author(s): Igarashi R, Ochiai S, Togano T, Sakaue Y, Suetake A, Iikawa R, Honma Y, Miyamoto D, Fukuchi T.
  • Journal Title: J Glaucoma. Volume: -
  • DOI: 10.1097/ijg.0000000000001492
  • Peer Reviewed / Open Access
• [Journal Article] Genetic Spectrum of EYS-associated Retinal Disease in a Large Japanese Cohort: Identification of Disease-associated Variants with Relatively High Allele Frequency. (2020)
  • Author(s): Yang L, Fujinami K, Ueno S, Kuniyoshi K, Hayashi T, Kondo M, Mizota A, Naoi N, Shinoda K, Kameya S, Fujinami-Yokokawa Y, Liu X, Arno G, Pontikos N, Kominami T, Terasaki H, Sakuramoto H, Katagiri S, Mizobuchi K, Nakamura N, Mawatari G, Kurihara T, Tsubota K, Miyake Y, Yoshitake K, Iwata T, Tsunoda K; JEGC study group.
  • Journal Title: Sci Rep Volume: 10 Pages: 1-10
  • DOI: 10.1038/s41598-020-62119-3
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Glaucoma-Associated Mutations in the Optineurin Gene Have Limited Impact on Parkin-Dependent Mitophagy. (2019)
  • Author(s): Chernyshova K, Inoue K, Yamashita SI, Fukuchi T, Kanki T.
  • Journal Title: Invest Ophthalmol Vis Sci. Volume: 60(10) Issue: 10 Pages: 3625-3625
  • DOI: 10.1167/iovs.19-27184
  • Peer Reviewed / Open Access
• [Journal Article] The natural course of IgG4-related ophthalmic disease after debulking surgery: a single-centre retrospective study. (2019)
  • Author(s): Ominato J, Oyama T, Cho H, Shiozaki N, Umezu H, Takizawa J, Fukuchi T.
  • Journal Title: BMJ Open Ophthalmol. Volume: 4(1)
  • DOI: 10.1136/bmjophth-2019-000295
  • Peer Reviewed / Open Access
• [Journal Article] Vision-related quality of life in Japanese patients with wet age-related macular degeneration treated with intravitreal aflibercept in a real-world setting. (2019)
  • Author(s): Gomi F, Migita H, Sakaguchi T, Okada H, Sugawara T, Hikichi Y; Participating Investigators.
  • Journal Title: Jpn J Ophthalmol. Volume: 63(6)
  • DOI: 10.1007/s10384-019-00687-2
  • Peer Reviewed / Open Access
• [Journal Article] Evaluation of deep convolutional neural networks for glaucoma detection. (2019)
  • Author(s): Phan S, Satoh S, Yoda Y, Kashiwagi K, Oshika T, Japan Ocular Imaging Registry Research Group.
  • Journal Title: Jpn J Ophthalmol Volume: Feb 24 Pages: 276-283
  • DOI: 10.1007/s10384-019-00659-6
  • Peer Reviewed / Open Access
• [Journal Article] Ocular hypotensive effects of prostaglandin analogs in Japanese patients with normal-tension glaucoma: a literature review. (2018)
  • Author(s): Takagi Y, Santo K, Hashimoto M, Fukuchi T.
  • Journal Title: Clin Ophthalmol. Volume: 12 Pages: 1837-1844
  • DOI: 10.2147/opth.s166657
  • Peer Reviewed / Open Access
• [Journal Article] Factors associated with fluctuations in repeated measurements of intraocular pressure using the Goldmann applanation tonometer in Japanese patients with primary open-angle glaucoma. (2018)
  • Author(s): Yaoeda Kiyoshi, Fukushima Atsushi, Shirakashi Motohiro, Miki Atsushi, Fukuchi Takeo
  • Journal Title: Clin Ophthalmol Volume: 12 Pages: 1473-1478
  • DOI: 10.2147/opth.s174277
  • Peer Reviewed / Open Access
• [Journal Article] The effect of concentric constriction of the visual field to 10 and 15 degrees on simulated motor vehicle accidents. (2018)
  • Author(s): Udagawa S, Ohkubo S, Iwase A, Susuki Y, Kunimatsu-Sanuki S, Fukuchi T, Matsumoto C, Ohno Y, Ono H, Sugiyama K, Araie M.
  • Journal Title: PLoS One. Volume: 13(3)
  • DOI: 10.1371/journal.pone.0193767
  • NAID: 120006452372
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy of predetermined therapeutic measures against bleb-related infection in the Collaborative Bleb-related Infection Incidence and Treatment Study (2018)
  • Author(s): Shoji Nobuyuki、Arakaki Yoshikuni、Nakamoto Kenji、Yamamoto Tetsuya、Kuwayama Yasuaki、The Collaborative Bleb-related Infection Incidence and Treatment Study Group
  • Journal Title: Acta Ophthalmol. Volume: 96
  • DOI: 10.1111/aos.13523
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 緑内障とquality of vision/quality of life (2018)
  • Author(s): 福地 健郎
  • Journal Title: 日本眼科学会雑誌 Volume: 122(10) Pages: 801-814
  • Peer Reviewed
• [Journal Article] PPGの診断と治療の考え方 (2018)
  • Author(s): 福地 健郎, 相澤 奈帆子, 溝上 志朗, 澤田 明
  • Journal Title: Frontiers in Glaucoma Volume: 55 Pages: 27-37
  • Peer Reviewed
• [Presentation] 前視野緑内障の診断と治療 (2019)
  • Author(s): 福地健郎
  • Organizer: 第123回日本眼科学会総会
• [Presentation] 新規ブリモニジン／チモロール配合点眼剤の第III 相長期投与試験 (2019)
  • Author(s): 福地健郎、新家眞、関弥卓郎
  • Organizer: 第73回日本臨床眼科学会
• [Presentation] Clustered Visual Field Progression of Primary Open-angle Glaucoma with Disc Hemorrhages in a Three-year Prospective Study, 2nd report. (2019)
  • Author(s): Takeo Fukuchi, Tetsuya Togano, Hidenobu Tanihara, Makoto Araie, Shinji Ohkubo, Tomomi Higashide, Kazuhisa Sugiyama, Goji Tomita, Chota Matsumoto, Atsuo Tomidokoro, Masanori Hangai, Hisashi Kawata, Hiroshi Inoue, Maya Inai, Yuki Tanaka.
  • Organizer: American Academy of Ophthalmology 2019
  • Int'l Joint Research
• [Presentation] Clustered Visual Field Progression of Primary Open-angle Glaucoma with Disc Hemorrhages in a Three-year Prospective Study. (2018)
  • Author(s): Takeo Fukuchi MD, Testuya Togano MD, PhD, Hidenobu Tanihara MD PhD, Makoto Araie MD, Goji Tomita MD, Chota Matsumoto MD, Shinji Ohkubo MD PhD, Atsuo Tomidokoro MD, Masanori Hangai MD, Kazuhisa Sugiyama, MD, PHD, Hisashi Kawata
  • Organizer: AAO
  • Int'l Joint Research
• [Presentation] Correlation Among Foveal Avascular Zone (FAZ) Detected by OCT Angiography and Inner Retinal Thickness, and Visual Filed Defects in POAG/NTG patients. (2018)
  • Author(s): Takeo Fukuchi, Ryoko Igarashi, Shun Ochiai, Tetsuya Togano, Yuta sakaue, Iikawa Ryu, Suetake Aki.
  • Organizer: EGS
  • Int'l Joint Research
• [Presentation] 緑内障の構造・視野に関する前向き観察研究におけるクラスタ別視野進行と乳頭出血 (2018)
  • Author(s): 福地健郎, 栂野哲哉, 谷原秀信, 東出朋巳, 大久保真司, 宇田川さち子, 杉山和久, 新家眞,冨田剛司, 松本長太, 富所敦男, 板谷正紀
  • Organizer: 第72回日本臨床眼科学会
• [Presentation] ハンフリー視野測定と進行判定 (2018)
  • Author(s): 福地健郎
  • Organizer: 第7回日本視野学会
  • Invited