| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Thirty-three eyes of 33 treatment-naive acute CSC patients and 50 age-matched healthy eyes were used as controls. Serum mitochondrial DNA (mtDNA) levels were measured by quantitative PCR. Serum levels of HMGB1 and 8-OHdG, biological markers of acute/chronic inflammation and oxidative stress, were also measured. serum mtDNA levels in the CSC group (36.5 ± 32.4 ng/mL) were significantly higher than in the control group (7.4 ± 5.9 ng/mL,p < 0.001) . Multivariate regression analysis showed that serum elevated mtDNA levels were significantly associated with higher serous retinal detachment. Serum mtDNA and HMGB1 were shown to be potential biomarkers of clinical activity and acute phase of CSC.
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