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Development of a new treatment for bullous keratopathy using a biocompatible crosslinking agent

Research Project

Project/Area Number 18K09407
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 56060:Ophthalmology-related
Research InstitutionOsaka University

Principal Investigator

Soma Takeshi  大阪大学, 大学院医学系研究科, 講師 (70582401)

Project Period (FY) 2018-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords水疱性角膜症 / 生体適合性架橋剤 / 家兎 / 架橋剤
Outline of Final Research Achievements

The effect of PEG-POG eye drops, a biocompatible cross-linking agent, on bullous keratopathy was investigated in a rabbit model. After ultrasonic phacoemulsification and aspiration of the lens of white rabbits, the corneal endothelium was physically scraped to create a bullous keratopathy model. The PEG-POG group was then treated with 5 wt% PEG-POG10 and the control group with saline every 5 minutes for 12 doses, and each group underwent anterior segment photography using a slit-lamp microscope, central corneal thickness measurement using a pachymeter, and histological examination (HE staining). The results showed a decrease in central corneal thickness in the PEG-POG group compared to the control group, confirming the efficacy of the cross-linking agent in bullous keratopathy.

Academic Significance and Societal Importance of the Research Achievements

水疱性角膜症に対する唯一の治療法は角膜移植であるが、課題としてドナー不足が挙げられる。また、角膜移植を初めとする臓器移植では他家の組織を移植するため、免疫学的な拒絶反応を避けることはできない。加えて、拒絶反応の発症を抑制するために長期間の眼局所および全身的な免疫抑制であり、緑内障や感染症、腎機能障害など合併症のリスクが非常に高い。本治療法の開発によって、水疱性角膜症の進行予防が可能になれば、角膜移植を要する患者の減少に寄与できると考える。

Report

(6 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (5 results)

All 2022 2020 2019

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 1 results) Presentation (2 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results)

  • [Journal Article] Correlation Between Angle Parameters and Central Corneal Thickness in Fuchs Endothelial Corneal Dystrophy2020

    • Author(s)
      Watanabe Shinya、Oie Yoshinori、Miki Atsuya、Soma Takeshi、Koh Shizuka、Kawasaki Satoshi、Tsujikawa Motokazu、Jhanji Vishal、Nishida Kohji
    • Journal Title

      Cornea

      Volume: 39 Issue: 5 Pages: 540-545

    • DOI

      10.1097/ico.0000000000002220

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] NS Endo-Inserter: A New Graft Inserter for Descemet Stripping Automated Endothelial Keratoplasty2019

    • Author(s)
      Soma Takeshi、Koh Shizuka、Maeda Naoyuki、Nishida Kohji
    • Journal Title

      Cornea

      Volume: 38 Issue: 1 Pages: S42-S44

    • DOI

      10.1097/ico.0000000000002086

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Efficacy of therapeutic soft contact lens in the management of gelatinous drop-like corneal dystrophy2019

    • Author(s)
      Maeno Sayo、Soma Takeshi、Tsujikawa Motokazu、Shigeta Ryujiro、Kawasaki Ryo、Oie Yoshinori、Koh Shizuka、Maruyama Kazuichi、Kawasaki Satoshi、Maeda Naoyuki、Nishida Kohji
    • Journal Title

      British Journal of Ophthalmology

      Volume: 104 Issue: 2 Pages: 241-246

    • DOI

      10.1136/bjophthalmol-2018-313809

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Peripheral iridectomy-how to make an ideal PI2022

    • Author(s)
      Takeshi Soma
    • Organizer
      EKLG GLOBAL Summit 2022
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] コラーゲン選択的架橋剤を用いた角膜実質再生治療法の開発2020

    • Author(s)
      相馬剛至
    • Organizer
      日本眼科手術学会
    • Related Report
      2019 Research-status Report
    • Invited

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Published: 2018-04-23   Modified: 2024-01-30  

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