Development of a new therapeutic approach for retinitis pigmentosa based on the iPS cell research
| Project/Area Number |
18K09422
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 56060:Ophthalmology-related
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| Research Institution | Keio University |
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Principal Investigator |
Ozawa Yoko 慶應義塾大学, 医学部(信濃町), 特任准教授 (90265885)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 網膜 / 神経保護 / iPS細胞 / 網膜色素変性 |
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| Outline of Final Research Achievements |
Retinitis Pigmentosa (RP) is a leading cause of blindness, worldwide. There are currently no treatments in the world. We previously reported that endoplasmic reticulum (ER) stress is one of the pathogenesis of RP, using RP patient-derived induced pluripotent stem cells (Yoshida, Ozawa, Okano et al. Mol. Brain 2014). In the current study, we performed in vivo analyses using RP model mice to show the proof of concept of the new therapeutic approach for RP focusing on ER stress.
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| Academic Significance and Societal Importance of the Research Achievements |
iPS細胞研究から発した新しい研究手法を用いた研究である点に大きな学術的意義があり、これまでに治療法の無い網膜色素変性に対する新規治療法の開発につながる研究である点に大きな社会的意義がある。疾患の分子メカニズムに着目した解析であり、病態に即した治療法の提案となる点が重要である。
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Report
(4 results)
Research Products
(62 results)
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[Journal Article] Myopia, corneal endothelial cell density and morphology in a Japanese population-based cross-sectional study: the JPHC-NEXT Eye Study2021
Author(s)
Naohiko Aketa, Miki Uchino, Motoko Kawashima, Yuichi Uchino, Kenya Yuki, Yoko Ozawa, Mariko Sasaki, Kazumasa Yamagishi, Norie Sawada, Shoichiro Tsugane, Hiroyasu Iso
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Journal Title
Scientific Reports
Volume: 11
Issue: 1
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Relationship between nerve fiber layer defect and the presence of epiretinal membrane in a Japanese population: The JPHC-NEXT Eye Study.2020
Author(s)
Uchida A, Sasaki M, Motomura K, Yuki K, Kurihara T, Tomita Y, Ozawa Y, Yamagishi K, Kawasaki R, Hanyuda A, Sawada N, Tsubota K, Tsugane S, Iso H.
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Journal Title
Sci Rep
Volume: 10
Issue: 1
Pages: 779-779
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] High Myopia and Its Associated Factors in JPHC-NEXT Eye Study: A Cross-Sectional Observational Study.2019
Author(s)
Mori K, Kurihara T, Uchino M, Torii H, Kawashima M, Sasaki M, Ozawa Y, Yamagishi K, Iso H, Sawada N, Tsugane S, Yuki K, Tsubota K.
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Journal Title
J Cli Med
Volume: 8
Issue: 11
Pages: 1788-1788
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Presentation] Factors associated with visual outcome after anti-vascular endothelial growth factor therapy in myopic choroidal neovascularization.2020
Author(s)
Minami S, Uchida A, Mushiga Y, Nagai N, Suzuki M, Watanabe K, Sonobe H, Kurihara T, Shinoda H, Tsubota K, Ozawa Y
Organizer
The Association for Research in Vision and Ophthalmology
Related Report
Int'l Joint Research
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[Presentation] Predictive factors for better short-term outcome in idiopathic epiretinal membrane after pars plana vitrectomy2018
Author(s)
Minami S, Shigeno Y, Shinoda H, Nagai N, Kurihara T, Kamoshita M, Watanabe K, Sonobe H, Hidaka Y, Tsubota K, Ozawa Y
Organizer
The Association for Research in Vision and Ophthalmology
Related Report
Int'l Joint Research
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