| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Outline of Final Research Achievements |
Feces, saliva, and conjunctival sac lavage fluid were collected from 14 cases of optic neuritis, 55 cases of uveitis, 80 cases of glaucoma, 70 cases of dry eye, and 80 cases of healthy subjects, DNA was extracted, and a next-generation sequence was performed. After that, grouping by OTU (Operational taxonomic unit) analysis and similarity search were performed. UniFrac analysis of the bacterial flora was performed between each disease group and the healthy subject group. As a result, 3 cases of enterobacteria were identified for optic neuritis. In uveitis, 18 cases of gut bacteria, 11 cases of oral bacteria, and 6 cases of conjunctival sac bacteria were identified. In glaucoma, 12 cases of gut bacteria, 11 cases of oral bacteria, and 6 cases of conjunctival sac bacteria were identified. In dry eye, 12 cases of gut bacteria, 10 cases of oral bacteria, and 13 cases of conjunctival sac bacteria were identified.
|
