| Project/Area Number |
18K09459
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 56060:Ophthalmology-related
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| Research Institution | Showa University |
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Principal Investigator |
Saito Yuta 昭和大学, 医学部, 准教授 (70407477)
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| Project Period (FY) |
2018-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 未熟児網膜症 / IGF-1 / VEGF / OIR / 動物モデル / 網膜展開標本 / 栄養 |
|---|
| Outline of Final Research Achievements |
Insulin-like growth factor-1 (IGF-1) is necessary for normal development of retinal vessels, and long-term low serum IGF-1 levels in premature infants are reported to increase the risk of retinopathy of prematurity, bronchopulmonary dysplasia, intracerebral hemorrhage, and necrotizing enterocolitis. It is believed that maintaining a high serum IGF-1 level from early in life may be a way to prevent postnatal complications. In this study, we examined whether administration of IGF-1 to an animal model of retinopathy of prematurity could prevent the onset and severity of retinopathy. The results revealed that, contrary to expectations, low levels of IGF-1 immediately after birth did not contribute to the worsening of retinopathy in the animal model, but rather that administration of IGF-1 worsened retinopathy.
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| Academic Significance and Societal Importance of the Research Achievements |
Insulin-like growth factor-1 (IGF-1)は網膜血管の正常な発達に必要で、未熟児における長期間の血清IGF-1の低値は未熟児網膜症のリスクを高めると報告されいるが、本研究の結果から生後早期から血清IGF-1濃度を高く保つためにIGF-1を投与することでは未熟児網膜症の発症・重症化を予防することが困難であることが予測される。
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