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Comprehensive three dimensional evaluation of macular disease with multi-functional optical coherence tomography

Research Project

Project/Area Number 18K09460
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 56060:Ophthalmology-related
Research InstitutionTokyo Medical University

Principal Investigator

Miura Masahiro  東京医科大学, 医学部, 教授 (60199958)

Co-Investigator(Kenkyū-buntansha) 安野 嘉晃  筑波大学, 医学医療系, 教授 (10344871)
カサラゴッド デイーパカマス  筑波大学, 数理物質系, 研究員 (40773908)
上野 勇太  筑波大学, 医学医療系, 講師 (90759317)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Keywords光干渉断層計 / 多機能光干渉断層計 / 網膜色素上皮 / メラニン / 黄斑疾患 / 偏光解消性 / 網膜色紙上皮 / マルチコントラスト光干渉断層計 / 網膜自家蛍光画像 / 脈絡膜 / 画像診断 / 偏光計測 / 血流計測
Outline of Final Research Achievements

In this project, we used multifunctional optical coherence tomography (OCT), that is a combination of polarization sensitive OCT and OCT angiography, to evaluate the 3-D distribution of retinal pigment epithelium (RPE) melanin in vivo human eyes. 1) We developed algorithm to calculate RPE melanin thickness map. 2) We evaluated RPE melanin thickness map in Vogt-Koyanagi-Harada disease and age-related macular degeneration, and conducted 3-D evaluation of retinal autofluoresceine imaging. From these studies, we confirmed 3-D evaluation of retinal autofluoresceine imaging is possible with multifunctional OCT, and demonstrated the clinical usefulness of multifunctional OCT for chorioretinal disease.

Academic Significance and Societal Importance of the Research Achievements

多機能OCTの臨床有用性が実証された。特に従来の手法では不可能であった、網膜自家蛍光画像の3次元解析が可能となった。この手法を用いれば、網脈絡膜疾患における網膜色素上皮細胞の高精度臨床解析が可能となる。また多機能OCTの小型化や安定化にも成功し、臨床現場で運用可能なことも実証した。そのため、多機能OCTを臨床現場で実地運用することは現状でも可能である。そのため、本研究で示した多機能OCTによる3次元多角的画像診断技術は、従来の手法では確認できなかった黄斑疾患に関する新しい知見をもたらす可能性がある。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (51 results)

All 2021 2020 2019 2018 Other

All Int'l Joint Research (2 results) Journal Article (8 results) (of which Int'l Joint Research: 2 results,  Open Access: 8 results,  Peer Reviewed: 7 results) Presentation (39 results) (of which Int'l Joint Research: 22 results,  Invited: 9 results) Remarks (2 results)

  • [Int'l Joint Research] University of Louisville/USC-Roski Eye Institute(米国)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] University of Louisville,/USC-Roski Eye Institute(米国)

    • Related Report
      2018 Research-status Report
  • [Journal Article] Evaluation of retinal pigment epithelium changes in serous pigment epithelial detachment in age-related macular degeneration2021

    • Author(s)
      Miura M, Makita S, Yasuno Y, Iwasaki T, Azuma S, Mino T, Yamaguchi T
    • Journal Title

      Sci Rep

      Volume: 11 Issue: 1 Pages: 2764-2764

    • DOI

      10.1038/s41598-021-82563-z

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Accurately motion-corrected Lissajous OCT with multi-type image registration2021

    • Author(s)
      Makita S, Miura M, Azuma S, Mino S, Yamaguchi T, Yasuno Y
    • Journal Title

      Biomed. Opt. Express

      Volume: 12 Issue: 1 Pages: 637-653

    • DOI

      10.1364/boe.409004

    • NAID

      120007192285

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 網膜自家蛍光画像2020

    • Author(s)
      三浦雅博
    • Journal Title

      Japanese Journal of Visual Science

      Volume: 41 Issue: 4 Pages: 88-91

    • DOI

      10.11432/jpnjvissci.41.88

    • NAID

      130007962622

    • ISSN
      0916-8273, 2188-0522
    • Related Report
      2020 Annual Research Report
    • Open Access
  • [Journal Article] Evaluation of retinal pigment epithelium layer change in Vogt-Koyanagi- Harada disease with multicontrast optical coherence tomography2019

    • Author(s)
      Miura M, Makita S, Azuma S,Yasuno Y, Sugiyama S, Mino M, Yamaguchi T, Agawa T, Iwasaki T, Usui Y, Rao NA, Goto H
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 60 Issue: 10 Pages: 3352-3362

    • DOI

      10.1167/iovs.19-27378

    • NAID

      120007132697

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Clinical multi-functional OCT for retinal imaging2019

    • Author(s)
      Azuma S, Makita S, Kasaragod D, Sugiyama S, Miura M, Yasuno Y
    • Journal Title

      Biomed. Opt. Express

      Volume: 10 Pages: 5724-5743

    • NAID

      120007127625

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evaluation of focal damage in the retinal pigment epithelium layer in serous retinal pigment epithelium detachment.2019

    • Author(s)
      Miura M, Makita S, Azuma S, Yasuno Y, Ueda S, Sugiyama S, Mino T, Yamaguchi T, Sandhu HS, Kaplan HJ, Iwasaki T, Goto H
    • Journal Title

      Sci Rep

      Volume: 9 Issue: 1 Pages: 3278-3278

    • DOI

      10.1038/s41598-019-39688-z

    • NAID

      120007133467

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Clinical prototype of pigment and flow imaging optical coherence tomography for posterior eye investigation2018

    • Author(s)
      Makita S, Mino T, Yamaguchi T, Miura M, Azuma S, Yasuno Y
    • Journal Title

      Biomed Opt Express

      Volume: 9 Pages: 4372-4389

    • NAID

      120007133765

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pixel-wise segmentation of severely pathologic retinal pigment epithelium and choroidal stroma using multi-contrast Jones matrix optical coherence tomography2018

    • Author(s)
      Azuma S, Makita S, Miyazawa A, Ikuno Y, Miura M, Yasuno Y
    • Journal Title

      Biomed Opt Express

      Volume: 9 Pages: 2955-2973

    • NAID

      120007134000

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Extending field-of-view of high-resolution retinal optical coherence tomography imagingusing Lissajous scan with slow drift2021

    • Author(s)
      Makita S, Azuma S, Mino S, Yamaguchi T, Miura M, Yasuno Y
    • Organizer
      Photonic West BiOS
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] マルチコントラストOCTによるVogt-小柳-原田病における網膜色素上細胞層変化の観察2020

    • Author(s)
      三浦雅博、巻田修一、東神之介、安野嘉晃、杉山聡、三野聡大、山口達夫、阿川哲也、岩崎琢也、臼井嘉彦、Nrasing Rao、後藤浩
    • Organizer
      第124回日本眼科学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Imaging of Retinal Disease by Clinical Jones-Matrix Optical Coherence Tomography2020

    • Author(s)
      Makita S, Azuma S, Miura M, Sugiyama S, Yasuno Y
    • Organizer
      OSA Biophotonics Congress: Biomedical Optics
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Objective evaluation of retinal pigment epithelium change in retinal pigment epithelium detachment with multi-contrast OCT2020

    • Author(s)
      Miura M, Makita S, Yasuno Y, Azuma S, Mino T, Yamaguchi T, Iwasaki T, Goto H
    • Organizer
      The Association for Research in Vision and Ophthalmology
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Compact and stable posterior multi-contrast Jones-matrix OCT for pigment, flow, and fibrotic tissue imaging2020

    • Author(s)
      Yasuno Y, Azuma S, Deepa K, Sugiyama S, Miura M, Makita S
    • Organizer
      The Association for Research in Vision and Ophthalmology
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Motion-free, three-dimensional optical coherence tomography imaging of retinal diseases2020

    • Author(s)
      Makita S, Miura M, Yamaguchi T, Mino T, Azuma S, Yasuno Y
    • Organizer
      The Association for Research in Vision and Ophthalmology
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Agent-free pigment-and-flow (PAF) imaging as a new en face retinal imaging modality2020

    • Author(s)
      Yasuno Y, Makita S, Mino T, Yamaguchi T, Shibutani M, Azuma S, Miura M
    • Organizer
      ARVO imaging conference
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] En face attenuation-and-flow imaging by swept-source OCT2020

    • Author(s)
      Makita S, Yamaguchi T, Mino T, Azuma S, Miura M, Yasuno Y
    • Organizer
      ARVO imaging conference
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] OCT何が見えて何が見えないか2020

    • Author(s)
      三浦雅博
    • Organizer
      第56回日本眼光学学会総会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] OCTの臨床応用2020

    • Author(s)
      三浦雅博
    • Organizer
      OCT講習会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] マルチコントラストOCTによる漿液性網膜色素上皮剥離における網膜色素上皮異常の観察2020

    • Author(s)
      三浦雅博、巻田修一、安野嘉晃、東神之介、山口達夫、三野聡大、岩崎琢也、後藤浩
    • Organizer
      第74回日本臨床眼科学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Three-dimensional evaluation of retinal autofluorescence imaging for age related macular degeneration2020

    • Author(s)
      Miura M, Makita S, Yasuno Y, Azuma S, Mino T, Yamaguchi T, Iwasaki T
    • Organizer
      American Academy of Ophthalmology
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The tolerance to motion in Lissajous scan optical coherence tomography2020

    • Author(s)
      Azuma S, Mino T, Yamaguchi T, Masahiro M, Makita S, Yoshiaki Y
    • Organizer
      Optics & Photonics Japan
    • Related Report
      2020 Annual Research Report
  • [Presentation] 3-D Evaluation of Retinal AF Imaging2020

    • Author(s)
      Miura M
    • Organizer
      The 1st Asia-Pacific Ocular Imaging Society congress
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Motion-free optical coherence tomography imaging of retinal disease using Lissajous scanning pattern2020

    • Author(s)
      Makita S, Miura M, Mino T, Azuma S, Yamaguchi T, Yasuno Y
    • Organizer
      Photonic West, BiOS
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Retinal pigment epithelium;melanin specific contrast imaging by multi-contrast OCT2020

    • Author(s)
      Miura M, Makita S, Azuma S, Yasuno Y, Mino T, Yamaguchi T, Sugiyama S, Iwasaki T
    • Organizer
      Photonic West, BiOS
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Acceleration of eye motion correction processing utilizing Lissajous scanning pattern in optical coherence tomography with GPGPU2020

    • Author(s)
      Mino T, Shibutani M, Azuma S, Shuichi Makita, Masahiro Miura, Yasuno Y, Yamaguchi T
    • Organizer
      Photonic West, BiOS
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] マルチコントラスト光干渉断層計による局所網膜色素上皮障害の検出2019

    • Author(s)
      三浦雅博、東神之介、巻田修一、安野嘉晃、杉山聡、山口達夫、三野聡大、上田俊一郎、岩崎琢也、後藤浩
    • Organizer
      第123回日本眼科学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] Comprehensive multi-functional retinal imager based on simplified Jones matrix OCT2019

    • Author(s)
      Yasuno Y, Azuma S, Makita S, Mino T, Yamaguchi T, Miura M
    • Organizer
      The Association for Research in Vision and Ophthalmology
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Evaluation of focal damage in the retinal pigment epithelium layer in serous retinal pigment epithelium detachment with multi-contrast OCT2019

    • Author(s)
      Miura M, Makita S, Azuma S, Yasuno Y, Ueda S, Sugiyama S, Mino T, Yamaguchi T, Sandhu HS, Kaplan HJ, Iwasaki T, Goto H
    • Organizer
      The Association for Research in Vision and Ophthalmology
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Motion-free, multi-contrast optical coherence tomography by Lissajous scan2019

    • Author(s)
      Makita S, Azuma S, Miura M, Yamaguchi T, Mino T, Yasuno Y
    • Organizer
      The Association for Research in Vision and Ophthalmology
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] OCTで何がわかるか2019

    • Author(s)
      三浦雅博
    • Organizer
      第20回 茨城眼科セミナー
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 網膜自家蛍光画像の3次元解析2019

    • Author(s)
      三浦雅博
    • Organizer
      第58回日本網膜硝子体学会総会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Motion-free imaging of retinal disease using Lissajous optical coherence tomography2019

    • Author(s)
      Makita S, Miura M, Mino T, Azuma S, Yamaguchi T, Yasuno Y
    • Organizer
      Optics & Photonics Japan
    • Related Report
      2019 Research-status Report
  • [Presentation] High-resolution motion-free multi-contrast optical coherence tomography with Lissajous scanning pattern2019

    • Author(s)
      Makita S, Miura M, Azuma S, Mino T, Yamaguchi T, Yasuno Y
    • Organizer
      Photonic West BiOS
    • Related Report
      2018 Research-status Report
  • [Presentation] Clinical Jones-matrix OCT for diagnosis of macular disease2019

    • Author(s)
      Azuma S, Makita S, Miura M, Mino T, Yamaguchi T, Yasuno Y
    • Organizer
      Photonic West BiOS
    • Related Report
      2018 Research-status Report
  • [Presentation] Automatic segmentation of lamina beam using multi-functional Jones matrix optical coherence tomography2018

    • Author(s)
      Kasaragod D, Makita S, Miura M, Yasuno Y
    • Organizer
      The Association for Research in Vision and Ophthalmology
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Evaluation of focal damage of retinal pigment epithelium layer in retinal pigment epithelium detachment by polarization sensitive optical coherence tomography2018

    • Author(s)
      Miura M, Makita S, Yasuno Y, Mihara R, Mino T, Yamaguchi T, Sugiyama S, Iwasaki T, Goto H
    • Organizer
      The Association for Research in Vision and Ophthalmology
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Macular analysis by multi-contrast segmentation of retinal pigment epithelium and choroid by Jones-matrix OCT2018

    • Author(s)
      Azuma S, Makita S, Ikuno Y, Miura M, Yasuno Y
    • Organizer
      The Association for Research in Vision and Ophthalmology
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Multi-functional posterior eye imaging by polarization-diversity optical coherence tomography2018

    • Author(s)
      Makita S, Mino T, Yamaguchi T, Miura M, Azuma S, Yasuno Y
    • Organizer
      ARVO Imaging in the Eye Conference
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Melanin Imaging by PS-OCT, NIR-FAF, and Polarization Sensitive SLO2018

    • Author(s)
      Miura M
    • Organizer
      World Ophthalmology Congress
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 眼底マルチコントラストOCTによる次世代多角的画像解析2018

    • Author(s)
      三浦雅博
    • Organizer
      第54回 日本眼光学学会総会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] マルチコントラスト光干渉断層計による自家蛍光画像3次元解析2018

    • Author(s)
      三浦雅博、東神之介、巻田修一、安野嘉晃、岩崎琢也、後藤浩
    • Organizer
      第72回日本臨床眼科学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 光干渉断層計 今後の展開2018

    • Author(s)
      三浦雅博
    • Organizer
      第39回日本レーザー医学会総会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Three dimensional analysis of retinal auto-fluorescence images by polarization sensitive optical coherence tomography2018

    • Author(s)
      Miura M, Azuma S, Makita S, Yasuno Y, Mihara R, Asakage M, Mino T, Yamaguchi T, Sugiyama S, Iwasaki T, Goto H
    • Organizer
      Annual meeting of American Academy of Ophthalmology
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Jones matrix OCTによる網膜色素上皮と脈絡膜間質の自動弁別2018

    • Author(s)
      東神之介、巻田修一、三浦雅博、生野恭司、安野嘉晃
    • Organizer
      第57回日本網膜硝子体学会総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 臨床プロトタイプ偏光 OCT による眼底の色素上皮・血管異常観察2018

    • Author(s)
      巻田修一、三浦雅博、三野聡大、山口達夫、東神之介、安野嘉晃
    • Organizer
      第57回日本網膜硝子体学会総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 偏光感受型光干渉断層計による網膜色素上皮障害の検討2018

    • Author(s)
      三浦雅博、東神之介、巻田修一、安野嘉晃、三原理恵子、杉山聡、山口達夫、三野聡大、岩崎琢也、後藤浩
    • Organizer
      第57回日本網膜硝子体学会総会
    • Related Report
      2018 Research-status Report
  • [Presentation] PS-OCT in high myopia2018

    • Author(s)
      Miura M
    • Organizer
      12th Asia-Pacific Vitreo-retina Society Congress
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Remarks] Dr. Masahiro Miura's Page

    • URL

      http://www.tokyo-med.ac.jp/iba-eye/miura_title.html

    • Related Report
      2020 Annual Research Report 2019 Research-status Report
  • [Remarks] About Masahiro Miura, M.D., Ph.D

    • URL

      http://www.tokyo-med.ac.jp/iba-eye/miura_title.html

    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2022-01-27  

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