Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Outline of Final Research Achievements |
Triplet repeat expansion of CTG in TCF4 was reported to be most common causative of Fuchs endothelial corneal dystrophy (FECD). However, how CTG repeat induce FECD is still unclear. In the current study, we demonstrated dysregulated genes in FECD by the use of RNAseq. Subsequently, dysregulated signaling pathways were determined based on RNAseq followed by validation study using cultured corneal endothelial cells established from the patients with FECD. Additionally, mouse model possessing CTG repeat expansion in TCF4 was generated.
|